Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.39 |
| ▸ | CASP3 | P42574 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22909125 | 0.83 | SOD1 (0.40) | CASP3RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL22904556 | 0.81 | TDP2 (0.39) | MMP13ALDH1A1HTTSMN1; SMN2MTNR1A | |
| SCHEMBL22906346 | 0.77 | ACHE (0.41) | MMP13ALDH1A1HSD17B10 | |
| SCHEMBL26473527 | 0.73 | HDAC4 (0.41) | CASP3 | |
| SCHEMBL5681744 | 0.70 | PTPN1 (0.56) | ALDH1A1HTTSMN1; SMN2KDM4EFFAR1 | |
| SCHEMBL660541 | 0.70 | MMP13 (0.70) | MMP13RAB9AALDH1A1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29194804 | 0.69 | MMP13 (0.68) | MMP13RAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL18648169 | 0.68 | FFAR1 (0.51) | MMP13ALDH1A1HTTSMN1; SMN2MTNR1A | |
| SCHEMBL22904554 | 0.68 | LMNA (0.44) | CASP3ALDH1A1HTTSMN1; SMN2KDM4E | |
| SCHEMBL12968963 | 0.68 | ROCK2 (0.60) | MMP13ALDH1A1HTTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |