Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27981110 | 0.83 | CTSD (0.51) | GAASMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL30104115 | 0.78 | HCRTR1 (0.54) | GAAALDH1A1HTTLMNAMAPT | |
| SCHEMBL22994535 | 0.78 | GAA (0.46) | GAASMN1; SMN2ALDH1A1HTTLMNA | |
| SCHEMBL27152360 | 0.77 | PKM (0.48) | GAASMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL1856862 | 0.77 | SLC6A3 (0.56) | GAASMN1; SMN2ALDH1A1HTTLMNA | |
| SCHEMBL28319862 | 0.77 | NPC1 (0.44) | SMN1; SMN2ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL14639033 | 0.75 | LMNA (0.50) | ALDH1A1LMNAMAPTKDM4EKMT2A | |
| SCHEMBL316291 | 0.75 | SGMS2 (0.53) | GAAALDH1A1HTTLMNAMAPT | |
| SCHEMBL13734754 | 0.74 | POLB (0.46) | GAASMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL29487353 | 0.74 | POLB (0.46) | GAASMN1; SMN2ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4545535-A1 | THIENOPYRIMIDINE DERIVATIVES AS ACC INHIBITORS AND USES THEREOF | Gilead Sciences, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| EP-4010344-B1 | THIENOPYRIMIDINE DERIVATIVES AS ACC INHIBITORS AND USES THEREOF | GILEAD SCIENCES INC (US) | 2024-10-02 | — | — | EP | disclosed |
| CN-114206884-B | Thienopyrimidine derivatives as ACC inhibitors and use thereof | 吉利德科学公司 | 2024-07-12 | — | — | CN | disclosed |
| EP-4010344-A1 | THIENOPYRIMIDINE DERIVATIVES AS ACC INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2022-06-15 | — | — | EP | disclosed |
| US-11352371-B2 | Thienopyrimidine derivatives as ACC inhibitors and uses thereof | GILEAD SCIENCES, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| CN-114206884-A | Thienopyrimidine derivatives as ACC inhibitors and uses thereof | 吉利德科学公司 | 2022-03-18 | — | — | CN | disclosed |
| US-20210053990-A1 | THIENOPYRIMIDINE DERIVATIVES AS ACC INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. | 2021-02-25 | — | — | US | disclosed |
| WO-2021030142-A1 | THIENOPYRIMIDINE DERIVATIVES AS ACC INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2021-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352371-B2 | Thienopyrimidine derivatives as ACC inhibitors and uses thereof | ACACB, ACACA, ACAT2 | GAA 320/4885SMN1; SMN2 4605/4885ALDH1A1 103/4885 |
| US-20210053990-A1 | THIENOPYRIMIDINE DERIVATIVES AS ACC INHIBITORS AND USES THEREOF | ACACA, ACACB, ACAT2 | GAA 244/4885SMN1; SMN2 4656/4885ALDH1A1 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.