SCHEMBL2298550

SCHEMBL2298550

N#Cc1ncc(Cl)cc1F

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
EGLN2 Q96KS0 2/20 0.40
CYP11B2 P19099 2/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40
CYP11B1 P15538 1/20 0.40
S1PR3 Q99500 13/20 0.37
S1PR1 P21453 12/20 0.37
S1PR2 O95136 2/20 0.35
S1PR4 O95977 1/20 0.35
KHK P50053 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL186605 0.78 KDM4E (0.47) CYP11B2KDM4EALDH1A1POLB
SCHEMBL29929823 0.78 EGLN2 (0.42) EGLN2CYP11B2KDM4EALDH1A1POLB
SCHEMBL186339 0.78 EGLN2 (0.42) EGLN2CYP11B2KDM4EALDH1A1POLB
SCHEMBL34470891 0.78 ALDH1A1 (0.50) EGLN2CYP11B2KDM4EALDH1A1CYP11B1
SCHEMBL12099239 0.77 ALDH1A1 (0.41) CYP11B2KDM4EALDH1A1POLBCYP11B1
SCHEMBL4586295 0.75 KDM4E (0.40) KDM4EALDH1A1POLBS1PR3S1PR1
SCHEMBL11155546 0.75 KDM4E (0.40) CYP11B2KDM4EALDH1A1POLBCYP11B1
SCHEMBL1973193 0.75 ALDH1A1 (0.40) KDM4EALDH1A1POLB
SCHEMBL12838156 0.75 KDM4E (0.40) CYP11B2KDM4EALDH1A1POLBCYP11B1
SCHEMBL125638 0.75 PIK3CD (0.51) KDM4EALDH1A1POLBKHK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12600709-B2 Nonpeptide somatostatin type 5 receptor agonists and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2026-04-14 US disclosed
US-12441754-B2 Galactoside inhibitor of galectins GALECTO BIOTECH AB (DK) 2025-10-14 US disclosed
US-20250136573-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF Crinetics Pharmaceuticals, Inc. 2025-05-01 US disclosed
CN-119504705-A Non-peptide somatostatin 5 receptor agonists and uses thereof 克林提克斯医药股份有限公司 2025-02-25 CN disclosed
CN-114585614-B Non-peptide somatostatin 5 receptor agonists and uses thereof 克林提克斯医药股份有限公司 2024-12-03 CN disclosed
CN-117843565-A Preparation method and application of pyridine compound 南京正荣医药化学有限公司 2024-04-09 CN disclosed
US-20230014870-A1 NOVEL GALACTOSIDE INHIBITOR OF GALECTINS GALECTO BIOTECH AB (DK) 2023-01-19 US disclosed
US-11479540-B2 Nonpeptide somatostatin type 5 receptor agonists and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2022-10-25 US disclosed
CN-110885319-B Sulfonamide compounds as sodium channel blockers and uses thereof 成都康弘药业集团股份有限公司 2022-08-12 CN disclosed
CN-110885328-B Sulfonamide compounds as sodium channel blockers and uses thereof 成都康弘药业集团股份有限公司 2022-08-12 CN disclosed
US-20090253737-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS, INCORPORATED 2009-10-08 US disclosed
WO-2009099594-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS CYTOKINETICS, INCORPORATED (US) 2009-08-13 WO disclosed
WO-2008121333-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS CYTOKINETICS, INCORPORATED (US) 2008-10-09 WO disclosed
WO-2008121333-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS CYTOKINETICS, INCORPORATED (US) 2008-10-09 WO disclosed
US-20080242695-A1 Certain Chemical Entities, Compositions, and Methods CYTOKINETICS, INC. 2008-10-02 US disclosed
US-20080242695-A1 Certain Chemical Entities, Compositions, and Methods CYTOKINETICS, INC. 2008-10-02 US disclosed
US-20080242695-A1 Certain Chemical Entities, Compositions, and Methods CYTOKINETICS, INC. 2008-10-02 US disclosed
US-6204221-B1 Herbicides SYNGENTA CROP PROTECTION, INC. 2001-03-20 US disclosed
EP-0941222-A2 PYRAZOLE DERIVATIVES USEFUL AS HERBICIDES Novartis AG (CH) 1999-09-15 EP disclosed
WO-1998021199-A2 PYRAZOLE DERIVATIVES USEFUL AS HERBICIDES NOVARTIS AG (CH) 1998-05-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11479540-B2 Nonpeptide somatostatin type 5 receptor agonists and uses thereof SSTR5, SSTR4, SSTR3 EGLN2 679/4885CYP11B2 1224/4885KDM4E 4514/4885
US-20230014870-A1 NOVEL GALACTOSIDE INHIBITOR OF GALECTINS LGALS1, LGALS3, LGALS2 EGLN2 2977/4885CYP11B2 423/4885KDM4E 3905/4885
US-20090253737-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS TNNC1, TNNI3, TNNT2 EGLN2 3763/4885CYP11B2 1757/4885KDM4E 4841/4885
US-20080242695-A1 Certain Chemical Entities, Compositions, and Methods TNNC1, TNNI3, TNNT2 EGLN2 4220/4885CYP11B2 2387/4885KDM4E 4360/4885
US-20250136573-A1 NONPEPTIDE SOMATOSTATIN TYPE 5 RECEPTOR AGONISTS AND USES THEREOF SSTR5, SSTR4, SSTR3 EGLN2 679/4885CYP11B2 1224/4885KDM4E 4514/4885
US-12441754-B2 Galactoside inhibitor of galectins LGALS1, LGALS3, LGALS2 EGLN2 2859/4885CYP11B2 471/4885KDM4E 3880/4885
US-12600709-B2 Nonpeptide somatostatin type 5 receptor agonists and uses thereof SSTR5, SSTR4, GLP1R EGLN2 1178/4885CYP11B2 1699/4885KDM4E 1542/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.