Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | RECQL | P46063 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | GLB1 | P16278 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | CTRC | Q99895 | 1/20 | 0.43 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8359568 | 0.92 | TDP1 (0.43) | ALDH1A1TDP1HPGDMEN1KMT2A | |
| SCHEMBL202598 | 0.87 | ALDH1A1 (0.48) | ALDH1A1TDP1HPGDMEN1KMT2A | |
| SCHEMBL154596 | 0.85 | MEN1 (0.40) | ALDH1A1TDP1HPGDMEN1KMT2A | |
| SCHEMBL8034668 | 0.84 | TDP1 (0.45) | ALDH1A1TDP1HPGDMEN1KMT2A | |
| SCHEMBL6816059 | 0.84 | SMAD3 (0.36) | ALDH1A1TDP1HPGDMEN1KMT2A | |
| SCHEMBL204164 | 0.78 | ALDH1A1 (0.48) | ALDH1A1TDP1HPGDMEN1KMT2A | |
| SCHEMBL5094500 | 0.78 | THRB (0.41) | ALDH1A1TDP1HPGDMEN1KMT2A | |
| SCHEMBL1682554 | 0.76 | SMAD3 (0.40) | ALDH1A1TDP1HPGDMEN1KMT2A | |
| SCHEMBL5958386 | 0.76 | SMAD3 (0.36) | ALDH1A1TDP1HPGDMEN1KMT2A | |
| SCHEMBL20484291 | 0.75 | SMAD3 (0.35) | ALDH1A1TDP1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0500779-B1 | 4,7-DICHLOROFLUORESCEIN DYES AS MOLECULAR PROBES | PERKIN ELMER CORP (US) | 1999-04-21 | — | — | EP | claimed |
| US-5188934-A | Long wavelength, narrow emission bandwidth fluorescent dyes; automatic DNA sequencing | APPLIED BIOSYSTEMS, INC. (US) | 1993-02-23 | — | — | US | claimed |
| US-20120003667-A1 | ELECTROPHORETIC TAG-BASED IN VITRO ASSAY TO QUANTIFY DIMERIZATION OF P66 AND P51 SUB-UNITS OF HIV-1 REVERSE TRANSCRIPTASE (RT) | MONOGRAM BIOSCIENCES, INC. | 2012-01-05 | — | — | US | disclosed |
| WO-2008156720-A1 | ELECTROPHORETIC TAG-BASED IN VITRO ASSAY TO QUANTIFY DIMERIZATION OF P66 AND P51 SUBUNITS OF HIV-1 REVERSE TRANSCRIPTASE (RT) | MONOGRAM BIOSCIENCES, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| US-7105308-B2 | Detecting receptor oligomerization | MONOGRAM BIOSCIENCES, INC. (US) | 2006-09-12 | — | — | US | disclosed |
| US-20060063734-A1 | 4,7-dichlorofluorescein dyes as molecular probes | APPLERA CORPORATION (US) | 2006-03-23 | — | — | US | disclosed |
| US-20050084870-A1 | 4,7-dichlorofluorescein dyes as molecular probes | APPLERA CORPORATION (US) | 2005-04-21 | — | — | US | disclosed |
| EP-0978569-B1 | METHOD OF DNA SEQUENCING | RIKAGAKU KENKYUSHO (JP) | 2004-09-22 | — | — | EP | disclosed |
| US-6649598-B2 | Detecting preferential nuclelotide sequences in sample; obtain nucleotide sequences, incubate with label and polymerase, recover labeled nuclelotides | APPLERA CORPORATION | 2003-11-18 | — | — | US | disclosed |
| US-6482938-B1 | Compounds having energy transfer function and method for DNA base sequencing by using the same | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2002-11-19 | — | — | US | disclosed |
| US-20020081616-A1 | 4,7-dichlorofluorescein dyes as molecular probes | THE PERKIN-ELMER CORPORATION | 2002-06-27 | — | — | US | disclosed |
| US-6265569-B1 | HAS ALKYL LINKER INCLUDING DOUBLE OR TRIPLE BOND WHICH ATTACHES FLUORESCENT MOLECULE TO NUCLEOTIDE; FOR TERMINATORS IN DNA SEQUENCING USING RNA POLYMERASES | THE INSTITUTE OF PHYSICAL AND CHEMICAL RESEARCH (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-1046648-A1 | 3'-DEOXYRIBONUCLEOTIDE DERIVATIVES | THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH (JP) | 2000-10-25 | — | — | EP | disclosed |
| US-6096723-A | POLYNUCLEOTIDE LABELED WITH 4-7-DICHLOROFLUORESCEIN DERIVATIVE; LONG WAVELENGTH, NARROW EMISSION BANDWIDTH, SAMPLE ANALYSIS RESOLUTION | THE PERKIN-ELMER CORPORATION (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0978569-A1 | METHOD OF DNA SEQUENCING | THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH (JP) | 2000-02-09 | — | — | EP | disclosed |
| EP-0967219-A1 | COMPOUNDS HAVING ENERGY TRANSFER FUNCTION AND METHOD FOR DNA BASE SEQUENCING BY USING THE SAME | THE INSTITUTE OF PHYSICAL & CHEMICAL RESEARCH (JP) | 1999-12-29 | — | — | EP | disclosed |
| EP-0500779-B1 | 4,7-DICHLOROFLUORESCEIN DYES AS MOLECULAR PROBES | PERKIN ELMER CORP (US) | 1999-04-21 | — | — | EP | disclosed |
| EP-0658167-B1 | 4,7-DICHLOROFLUORESCEIN DYES AS MOLECULAR PROBES | PERKIN ELMER CORP (US) | 1999-04-14 | — | — | EP | disclosed |
| US-5654442-A | DETECTING OVERLAPPING TARGETS; DNA ANALYSIS | THE PERKIN-ELMER CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |
| US-5188934-A | Long wavelength, narrow emission bandwidth fluorescent dyes; automatic DNA sequencing | APPLIED BIOSYSTEMS, INC. (US) | 1993-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063734-A1 | 4,7-dichlorofluorescein dyes as molecular probes | SPAG5, SPG11, SPIN4 | ALDH1A1 795/4885TDP1 61/4885HPGD 3969/4885 |
| US-20050084870-A1 | 4,7-dichlorofluorescein dyes as molecular probes | DCLRE1B, DCTD, DDB1 | ALDH1A1 405/4885TDP1 288/4885HPGD 2844/4885 |
| US-20020081616-A1 | 4,7-dichlorofluorescein dyes as molecular probes | SPAG5, SPG11, SPIN4 | ALDH1A1 658/4885TDP1 96/4885HPGD 3902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.