Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGAM1 | P18669 | 1/20 | 0.49 |
| ▸ | ACLY | P53396 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 4/20 | 0.44 |
| ▸ | MRGPRX1 | Q96LB2 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13469210 | 0.78 | MRGPRX1 (0.50) | MRGPRX1KMT2ALMNAPOLBPTGS1 | |
| SCHEMBL20837041 | 0.76 | KDM4E (0.53) | PGAM1ACLYBRD4MRGPRX1KDM4E | |
| SCHEMBL23014676 | 0.76 | ACLY (0.65) | PGAM1ACLYMRGPRX1KDM4EKMT2A | |
| SCHEMBL4963565 | 0.75 | KEAP1 (0.55) | KDM4EKMT2APTGS1ALDH1A1 | |
| SCHEMBL10878124 | 0.74 | KDM4E (0.50) | PGAM1ACLYBRD4MRGPRX1KDM4E | |
| SCHEMBL23014657 | 0.73 | PGAM1 (0.46) | PGAM1ACLYBRD4MRGPRX1KDM4E | |
| SCHEMBL23014686 | 0.72 | KDM4E (0.57) | ACLYMRGPRX1KDM4EKMT2APOLB | |
| SCHEMBL10650094 | 0.72 | BRD4 (0.52) | PGAM1ACLYBRD4PTGS1PTGS2 | |
| SCHEMBL1014583 | 0.71 | COMT (0.44) | EPHX1KMT2AALDH1A1 | |
| SCHEMBL13510398 | 0.71 | EP300 (0.53) | PGAM1ACLYBRD4MRGPRX1CKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12540115-B2 | Inhibitors of phospholipid synthesis and methods of use | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2026-02-03 | — | — | US | disclosed |
| US-20220315528-A1 | INHIBITORS OF PHOSPHOLIPID SYNTHESIS AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2022-10-06 | — | — | US | disclosed |
| WO-2021035031-A1 | INHIBITORS OF PHOSPHOLIPID SYNTHESIS AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2021-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220315528-A1 | INHIBITORS OF PHOSPHOLIPID SYNTHESIS AND METHODS OF USE | LCAT, AGPAT2, AGPAT5 | PGAM1 144/4885ACLY 879/4885BRD4 761/4885 |
| US-12540115-B2 | Inhibitors of phospholipid synthesis and methods of use | LCAT, DGAT1, DGAT2 | PGAM1 335/4885ACLY 195/4885BRD4 1607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.