Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20566659 | 0.83 | MAPT (0.43) | ALDH1A1KMT2ACYP1A2CYP2D6NR1H4 | |
| SCHEMBL7421479 | 0.82 | GABRG2 (0.40) | KMT2AGABRG2GABRB3GABRA5NPC1 | |
| SCHEMBL28074789 | 0.78 | SCN4A (0.38) | ALDH1A1GABRG2GABRB3GABRA5MAPT | |
| SCHEMBL22263387 | 0.77 | GABRG2 (0.36) | ALDH1A1KMT2AGABRG2GABRB3GABRA5 | |
| SCHEMBL22190961 | 0.76 | HPGDS (0.39) | ALDH1A1ELANEGABRG2GABRB3GABRA5 | |
| SCHEMBL1421920 | 0.75 | NOS1 (0.47) | ALDH1A1KMT2ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL24969825 | 0.72 | KMT2A (0.36) | ALDH1A1KMT2ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL27610277 | 0.71 | TSHR (0.49) | ALDH1A1KMT2AGABRG2GABRB3GABRA5 | |
| SCHEMBL16709634 | 0.70 | KEAP1 (0.49) | KMT2ANR1H2NPC1RAB9AL3MBTL1 | |
| SCHEMBL28788197 | 0.70 | KMT2A (0.37) | ALDH1A1KMT2AELANEF2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10927105-B1 | Pyrazole MAGL inhibitors | LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) | 2021-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927105-B1 | Pyrazole MAGL inhibitors | MGLL, PNLIP, LPL | ALDH1A1 2448/4885KMT2A 3777/4885CYP1A2 335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.