SCHEMBL23064293

SCHEMBL23064293

Clc1ccc2c(N3CCN(c4ccccc4Cl)CC3)noc2c1

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 8/20 0.48
HTR1A P08908 1/20 0.48
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
MAPT P10636 1/20 0.44
AVPR1A P37288 1/20 0.43
HTR7 P34969 8/20 0.42
HTR6 P50406 8/20 0.42
DRD2 P14416 5/20 0.42
RECQL P46063 1/20 0.40
ADRB1 P08588 1/20 0.40
CHRNA7 P36544 2/20 0.39
HTR3A P46098 2/20 0.39
NPC1 O15118 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30777987 1.00 HTR2A (0.48) HTR2AHTR1AKDM4EALDH1A1MAPT
SCHEMBL23074485 0.88 MAPT (0.46) HTR2AHTR1AKDM4EALDH1A1MAPT
SCHEMBL23064319 0.86 SORD (0.50) HTR2AHTR1AKDM4EALDH1A1MAPT
SCHEMBL30778007 0.86 SORD (0.50) HTR2AHTR1AKDM4EALDH1A1MAPT
SCHEMBL23064393 0.84 HTR7 (0.49) HTR2AHTR1AHTR7HTR6DRD2
SCHEMBL30778015 0.84 HTR7 (0.49) HTR2AHTR1AHTR7HTR6DRD2
SCHEMBL9035904 0.81 MAT2A (0.48) HTR2AHTR1AKDM4EALDH1A1MAPT
Hydrochloric Acid SCHEMBL9037461 0.80 MAT2A (0.47) HTR2AHTR1AKDM4EALDH1A1CHRNA7
SCHEMBL1840383 0.79 HRH4 (0.48) HTR2AHTR1AHTR7HTR6ADRB1
SCHEMBL13448295 0.78 HTT (0.54) HTR2AHTR1AKDM4EALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250170116-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND/OR TREATING RENAL DISEASE OSAKA UNIVERSITY (JP) 2025-05-29 US disclosed
US-20250073229-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND/OR TREATING HEART FAILURE SHINSHU UNIVERSITY (JP) 2025-03-06 US disclosed
EP-4487848-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND/OR TREATING RENAL DISEASE OSAKA UNIVERSITY (JP) 2025-01-08 EP disclosed
EP-4461296-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND/OR TREATING HEART FAILURE Osaka University (JP) 2024-11-13 EP disclosed
US-20240307375-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND/OR TREATING KIDNEY INJURY, AND AUTOPHAGY ACTIVATOR KYOTO UNIVERSITY (JP) 2024-09-19 US disclosed
EP-4364739-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND/OR TREATING KIDNEY INJURY, AND AUTOPHAGY ACTIVATOR OSAKA UNIVERSITY (JP) 2024-05-08 EP disclosed
US-11976062-B2 Benzisoxazole compound OSAKA UNIVERSITY (JP) 2024-05-07 US disclosed
EP-3789383-B9 INHIBITORS OF THE TRPC3 OR TRPC6 CHANNEL UNIV OSAKA (JP) 2024-02-28 EP disclosed
CN-117580577-A Pharmaceutical composition for preventing and/or treating kidney injury and autophagy activator 国立大学法人大阪大学 2024-02-20 CN disclosed
EP-3789383-B1 INHIBITORS OF THE TRPC3 OR TRPC6 CHANNEL UNIV OSAKA (JP) 2023-11-29 EP disclosed
WO-2023132208-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND/OR TREATING HEART FAILURE 国立大学法人大阪大学 2023-07-13 WO disclosed
US-20230114195-A1 BENZISOXAZOLE COMPOUND KYOTO UNIVERSITY (JP) 2023-04-13 US disclosed
US-11548882-B2 Benzisoxazole compound OSAKA UNIVERSITY (JP) 2023-01-10 US disclosed
US-11548882-B2 Benzisoxazole compound OSAKA UNIVERSITY (JP) 2023-01-10 US disclosed
WO-2023276828-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND/OR TREATING KIDNEY INJURY, AND AUTOPHAGY ACTIVATOR 国立大学法人大阪大学 2023-01-05 WO disclosed
US-20210238171-A1 BENZISOXAZOLE COMPOUND INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES (JP) 2021-08-05 US disclosed
US-20210238171-A1 BENZISOXAZOLE COMPOUND INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES (JP) 2021-08-05 US disclosed
WO-2021079962-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTION AND/OR TREATMENT OF HEARING LOSS 国立大学法人大阪大学 2021-04-29 WO disclosed
EP-3789383-A1 BENZISOXAZOLE COMPOUND Osaka University (JP) 2021-03-10 EP disclosed
CN-112204017-A Benzisoxazole compounds 国立大学法人大阪大学 2021-01-08 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238171-A1 BENZISOXAZOLE COMPOUND CBR1, CYP2S1, CYP2E1 HTR2A 4776/4885HTR1A 3701/4885KDM4E 1084/4885
US-20240307375-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND/OR TREATING KIDNEY INJURY, AND AUTOPHAGY ACTIVATOR ATG7, BECN1, SQSTM1 HTR2A 2633/4885HTR1A 1857/4885KDM4E 2158/4885
US-11976062-B2 Benzisoxazole compound CBR1, CYP2S1, CYP2E1 HTR2A 4780/4885HTR1A 3719/4885KDM4E 1080/4885
US-20250170116-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND/OR TREATING RENAL DISEASE REN, ATP6V1B1, CYP2S1 HTR2A 3869/4885HTR1A 2719/4885KDM4E 3121/4885
US-11548882-B2 Benzisoxazole compound CBR1, CYP2S1, CYP2E1 HTR2A 4776/4885HTR1A 3701/4885KDM4E 1084/4885
US-20230114195-A1 BENZISOXAZOLE COMPOUND CBR1, CYP2S1, CYP2E1 HTR2A 4738/4885HTR1A 3598/4885KDM4E 969/4885
US-20250073229-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND/OR TREATING HEART FAILURE CBR1, CYP2S1, CYP2F1 HTR2A 3378/4885HTR1A 2271/4885KDM4E 2741/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.