Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | UNG | P13051 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9640411 | 0.85 | ALDH1A1 (0.52) | ALDH1A1CYP2A6UNGMAOAMAOB | |
| SCHEMBL9640413 | 0.85 | ALDH1A1 (0.52) | ALDH1A1CYP2A6UNGMAOAMAOB | |
| SCHEMBL24598983 | 0.81 | NPC1 (0.61) | ALDH1A1CYP2A6MAOAMAOBMEN1 | |
| SCHEMBL2301281 | 0.80 | ALDH1A1 (0.59) | ALDH1A1CYP2A6MEN1KMT2AMAPT | |
| SCHEMBL7542217 | 0.80 | ALDH1A1 (0.59) | ALDH1A1CYP2A6MEN1KMT2AMAPT | |
| SCHEMBL29952896 | 0.79 | ALDH1A1 (0.47) | ALDH1A1CYP2A6UNGMAOAMAOB | |
| SCHEMBL14690443 | 0.78 | NFE2L2 (0.54) | ALDH1A1MAOAMAOBMEN1KMT2A | |
| SCHEMBL14690442 | 0.78 | NFE2L2 (0.54) | ALDH1A1MAOAMAOBMEN1KMT2A | |
| SCHEMBL14690444 | 0.78 | NFE2L2 (0.54) | ALDH1A1MAOAMAOBMEN1KMT2A | |
| SCHEMBL878514 | 0.78 | ALDH1A1 (0.50) | ALDH1A1CYP2A6UNGMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1176151-B1 | Synthesis of polynucleotides using combined oxidation/deprotection chemistry | AGILENT TECHNOLOGIES INC (US) | 2014-08-20 | — | — | EP | disclosed |
| US-8309706-B2 | Nucleosides; sodium/lithium/potassium peroxides as nucleophilic agents; solid phase synthesis | AGILENT TECHNOLOGIES, INC. (US) | 2012-11-13 | — | — | US | disclosed |
| US-20110189664-A1 | DIAGNOSTICS IN A MONOPLEX/MULTIPLEX FORMAT | UNIVERSITY OF WOLLONGONG | 2011-08-04 | — | — | US | disclosed |
| US-20090286696-A1 | Double-Stranded Olidonucleotides and Uses Therefor | UNIVERSITY OF WOLLONGONG | 2009-11-19 | — | — | US | disclosed |
| WO-2008148143-A1 | DIAGNOSTICS IN A MONOPLEX/MULTIPLEX FORMAT | UNIVERSITY OF WOLLONGONG (AU) | 2008-12-11 | — | — | WO | disclosed |
| US-20080206851-A1 | Methods and compositions for RNA synthesis | AGILENT TECHNOLOGIES, INC. | 2008-08-28 | — | — | US | disclosed |
| US-20080206850-A1 | new phosphoramidite compositions, that have Silyl-containing carbonate or thiocarbonate or ether as 5'-hydroxyl protecting groups useful of the synthesis of DNA, and in particular for the synthesis of long sequences of DNA | AGILENT TECHNOLOGIES, INC. | 2008-08-28 | — | — | US | disclosed |
| US-20080076913-A1 | Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection | DELLINGER DOUGLAS J | 2008-03-27 | — | — | US | disclosed |
| US-7271258-B2 | Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection | AGILENT TECHNOLOGIES, INC. (US) | 2007-09-18 | — | — | US | disclosed |
| US-7135565-B2 | Synthesis of polynucleotides using combined oxidation/deprotection chemistry | AGILENT TECHNOLOGIES, INC. (US) | 2006-11-14 | — | — | US | disclosed |
| US-7101986-B2 | Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection | AGILENT TECHNOLOGIES, INC. (US) | 2006-09-05 | — | — | US | disclosed |
| EP-1553102-A1 | Synthesis of oligonucleotides | Agilent Technologies, Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-0984021-B1 | Synthesis of oligonucleotides | AGILENT TECHNOLOGIES INC (US) | 2005-04-27 | — | — | EP | disclosed |
| US-20040230052-A1 | Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection | THE REGENTS OF THE UNIVERSITY OF COLORADO | 2004-11-18 | — | — | US | disclosed |
| US-6630581-B2 | Condensing the 3'-OH or 5'-OH group of a support-bound nucleoside or oligonucleotide with a monomeric nucleoside phosphoramidite having a carbonate-protected hydroxyl group; treating the intermediate provided with a deprotecting reagent | AGILENT TECHNOLOGIES, INC. | 2003-10-07 | — | — | US | disclosed |
| US-20020058802-A1 | Synthesis of polynucleotides using combined oxidation/deprotection chemistry | THE REGENTS OF THE UNIVERSITY OF COLORADO | 2002-05-16 | — | — | US | disclosed |
| US-20020045221-A1 | Solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection | THE REGENTS OF THE UNIVERSITY OF COLORADO | 2002-04-18 | — | — | US | disclosed |
| EP-1176151-A1 | Synthesis of polynucleotides using combined oxidation/deprotection chemistry | Agilent Technologies, Inc. (a Delaware corporation) (US) | 2002-01-30 | — | — | EP | disclosed |
| US-6222030-B1 | CONDENSING HYDROXY GROUP OF BOUND OLIGONUCLEOTIDE OR NUCLEOSIDE WITH NUCLEOSIDE PHOSPHORAMIDITE HAVING CARBONATE-PROTECTED HYDROXYL GROUP, TREATING WITH DEPROTECTING AGENT ALSO OXIDIZES PHOSPHITE TRIESTER LINKAGE | AGILENT TECHNOLOGIES, INC. | 2001-04-24 | — | — | US | disclosed |
| EP-0984021-A2 | Synthesis of oligonucleotides | Hewlett-Packard Company (US) | 2000-03-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020045221-A1 | Solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection | POLL, RNGTT, DNTT | ALDH1A1 2882/4885CYP2A6 3487/4885UNG 81/4885 |
| US-20080206850-A1 | new phosphoramidite compositions, that have Silyl-containing carbonate or thiocarbonate or ether as 5'-hydroxyl protecting groups useful of the synthesis of DNA, and in particular for the synthesis of long sequences of DNA | MTAP, OGG1, TYMP | ALDH1A1 4030/4885CYP2A6 1826/4885UNG 21/4885 |
| US-20040230052-A1 | Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection | POLL, DNTT, RNGTT | ALDH1A1 2740/4885CYP2A6 4006/4885UNG 25/4885 |
| US-20090286696-A1 | Double-Stranded Olidonucleotides and Uses Therefor | DNTT, ADAR, DUT | ALDH1A1 1826/4885CYP2A6 4774/4885UNG 74/4885 |
| US-20080206851-A1 | Methods and compositions for RNA synthesis | FBL, RNGTT, METTL3 | ALDH1A1 3403/4885CYP2A6 1744/4885UNG 184/4885 |
| US-20020058802-A1 | Synthesis of polynucleotides using combined oxidation/deprotection chemistry | RNGTT, NT5C3B, PNP | ALDH1A1 3264/4885CYP2A6 2864/4885UNG 14/4885 |
| US-20080076913-A1 | Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection | POLL, DNTT, RNGTT | ALDH1A1 2559/4885CYP2A6 3959/4885UNG 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.