Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ME2 | P23368 | 4/20 | 0.46 |
| ▸ | ME1 | P48163 | 4/20 | 0.46 |
| ▸ | ME3 | Q16798 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23244298 | 0.81 | ME2 (0.64) | MAPTLMNAUSP2MAPK1TSHR | |
| SCHEMBL12473723 | 0.76 | CES2 (0.59) | MAPTLMNAALDH1A1GAAMEN1 | |
| SCHEMBL6688051 | 0.76 | CES2 (0.59) | MAPTLMNAALDH1A1GAAMEN1 | |
| SCHEMBL12473724 | 0.76 | CES2 (0.59) | MAPTLMNAALDH1A1GAAMEN1 | |
| SCHEMBL6691216 | 0.75 | CA12 (0.53) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL32688379 | 0.75 | ALDH1A1 (0.80) | MAPTLMNAUSP2MAPK1TSHR | |
| SCHEMBL8931737 | 0.74 | DRD4 (0.67) | MAPTLMNAUSP2ALDH1A1GAA | |
| SCHEMBL2767441 | 0.71 | LMNA (0.74) | MAPTLMNAUSP2MAPK1TSHR | |
| SCHEMBL63954 | 0.71 | CES1 (0.50) | MAPTLMNAMAPK1TSHRALDH1A1 | |
| SCHEMBL6831019 | 0.70 | PBRM1 (0.59) | MAPTLMNATSHRALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11225480-B2 | Malic enzyme inhibitors | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2022-01-18 | — | — | US | disclosed |
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2021-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | ME1, ME2, ME3 | MAPT 2817/4885LMNA 4129/4885USP2 669/4885 |
| US-11225480-B2 | Malic enzyme inhibitors | ME1, RNASE1, ME2 | MAPT 3825/4885LMNA 3853/4885USP2 1267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.