Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 4/20 | 0.44 |
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.41 |
| ▸ | CHRM4 known ✓ | P08173 | 3/20 | 0.41 |
| ▸ | CHRM5 known ✓ | P08912 | 3/20 | 0.41 |
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.41 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.41 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | RAD52 | P43351 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5963139 | 0.97 | DNM1 (0.67) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| Bromide SCHEMBL14937200 | 0.91 | DNM1 (0.81) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| Bromide SCHEMBL1243173 | 0.90 | ALDH1A1 (0.64) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| Bromide SCHEMBL5088604 | 0.89 | DNM1 (0.72) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL13326548 | 0.89 | DNM1 (0.58) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL12762153 | 0.88 | DNM1 (0.81) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL374778 | 0.87 | ALDH1A1 (0.67) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| Bromide SCHEMBL20213856 | 0.87 | DNM1 (0.59) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL935685 | 0.86 | DNM1 (0.60) | DNM1MEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL4454094 | 0.86 | DNM1 (0.85) | DNM1MEN1KMT2ATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130172191-A1 | STABLE ETHYLENE INHIBITING COMPOUNDS AND METHODS FOR THEIR PREPARATION | AGROFRESH, INC. | 2013-07-04 | — | — | US | disclosed |
| US-20110190137-A1 | METHOD TO INHIBIT ETHYLENE RESPONSES IN PLANTS | JACOBSON RICHARD MARTIN | 2011-08-04 | — | — | US | disclosed |
| EP-1408751-B1 | A METHOD TO INHIBIT ETHYLENE RESPONSES IN PLANTS | ROHM & HAAS (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20100184600-A1 | Stable Ethylene Inhibiting Compounds and Methods for Their Preparation | AGROFRESH, INC. | 2010-07-22 | — | — | US | disclosed |
| EP-1408751-A4 | A METHOD TO INHIBIT ETHYLENE RESPONSES IN PLANTS | ROHM & HAAS (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1408752-B1 | A METHOD TO INHIBIT ETHYLENE RESPONSES IN PLANTS | ROHM & HAAS (US) | 2006-11-08 | — | — | EP | disclosed |
| US-7041625-B2 | Method to inhibit ethylene responses in plants | ROHM AND HAAS COMPANY (US) | 2006-05-09 | — | — | US | disclosed |
| EP-1409440-A4 | A METHOD TO INHIBIT ETHYLENE RESPONSES IN PLANTS | ROHM & HAAS (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20050065033-A1 | Method to inhibit ethylene responses in plants | JACOBSON RICHARD MARTIN (US) | 2005-03-24 | — | — | US | disclosed |
| US-20050043179-A1 | Method to inhibit ethylene responses in plants | AGROFRESH, INC. | 2005-02-24 | — | — | US | disclosed |
| US-6548448-B2 | Delivery systems for cyclopropenes | ROHM AND HAAS COMPANY | 2003-04-15 | — | — | US | disclosed |
| US-20020198107-A1 | Delivery systems for cyclopropenes | AGROFRESH, INC. | 2002-12-26 | — | — | US | disclosed |
| WO-2002068367-A1 | A METHOD TO INHIBIT ETHYLENE RESPONSES IN PLANTS | ROHM AND HAAS COMPANY (US) | 2002-09-06 | — | — | WO | disclosed |
| WO-2002068609-A2 | A METHOD TO INHIBIT ETHYLENE RESPONSES IN PLANTS | ROHM AND HAAS COMPANY (US) | 2002-09-06 | — | — | WO | disclosed |
| WO-2002067678-A1 | A METHOD TO INHIBIT ETHYLENE RESPONSES IN PLANTS | ROHM AND HAAS COMPANY (US) | 2002-09-06 | — | — | WO | disclosed |
| EP-1236397-A2 | Delivery systems for cyclopropenes | ROHM AND HAAS COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1233669-A2 | BLOCKING AN ETHYLENE RESPONSE IN PLANTS USING CYCLOPROPENE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2002-08-28 | — | — | EP | disclosed |
| US-6365549-B2 | PRESERVATION | NORTH CAROLINA STATE UNIVERSITY | 2002-04-02 | — | — | US | disclosed |
| US-20010019995-A1 | Methods of blocking an ethylene response in plants using cyclopropene derivatives | NORTH CAROLINA STATE UNIVERSITY | 2001-09-06 | — | — | US | disclosed |
| WO-2001037663-A2 | BLOCKING AN ETHYLENE RESPONSE IN PLANTS USING CYCLOPROPENE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2001-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010019995-A1 | Methods of blocking an ethylene response in plants using cyclopropene derivatives | PRUNE1, NOTUM, FAR1 | CHRM3 899/4885CHRM2 702/4885CHRM4 1448/4885 |
| US-20050065033-A1 | Method to inhibit ethylene responses in plants | ERN1, CTH, CBS | CHRM3 3098/4885CHRM2 2998/4885CHRM4 3407/4885 |
| US-20110190137-A1 | METHOD TO INHIBIT ETHYLENE RESPONSES IN PLANTS | ERN1, CTH, CBR3 | CHRM3 3009/4885CHRM2 2951/4885CHRM4 3356/4885 |
| US-20100184600-A1 | Stable Ethylene Inhibiting Compounds and Methods for Their Preparation | ECE1, ECE2, EI24 | CHRM3 2365/4885CHRM2 2086/4885CHRM4 2750/4885 |
| US-20130172191-A1 | STABLE ETHYLENE INHIBITING COMPOUNDS AND METHODS FOR THEIR PREPARATION | ECE1, ECE2, EI24 | CHRM3 2365/4885CHRM2 2086/4885CHRM4 2750/4885 |
| US-20050043179-A1 | Method to inhibit ethylene responses in plants | ERN1, ECE1, ECE2 | CHRM3 2763/4885CHRM2 2958/4885CHRM4 3072/4885 |
| US-20020198107-A1 | Delivery systems for cyclopropenes | FKBP2, FKBP4, FKBP1A | CHRM3 1746/4885CHRM2 2252/4885CHRM4 1624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.