Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 7/20 | 0.70 |
| ▸ | DCLRE1B | Q9H816 | 3/20 | 0.61 |
| ▸ | DCLRE1A | Q6PJP8 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL1931924 | 1.00 | FOLH1 (0.70) | FOLH1DCLRE1BDCLRE1AALDH1A1ALOX15 | |
| SCHEMBL4369777 | 0.83 | FOLH1 (1.00) | FOLH1DCLRE1BDCLRE1AALDH1A1ALOX15 | |
| SCHEMBL69352 | 0.81 | TSHR (0.68) | FOLH1ALDH1A1ALOX15TSHRMAPT | |
| SCHEMBL30365583 | 0.81 | FOLH1 (0.76) | FOLH1ALDH1A1ALOX15TSHRMAPT | |
| SCHEMBL70392 | 0.81 | FOLH1 (0.76) | FOLH1ALDH1A1ALOX15TSHRMAPT | |
| SCHEMBL7743246 | 0.81 | AKR1C3 (0.55) | FOLH1DCLRE1BDCLRE1AALDH1A1TSHR | |
| SCHEMBL2651867 | 0.81 | FOLH1 (0.56) | FOLH1DCLRE1BDCLRE1AALDH1A1ALOX15 | |
| SCHEMBL20141806 | 0.81 | FOLH1 (0.53) | FOLH1DCLRE1BDCLRE1AALDH1A1ALOX15 | |
| SCHEMBL1931921 | 0.81 | DCLRE1B (0.56) | FOLH1DCLRE1BDCLRE1AALDH1A1ALOX15 | |
| SCHEMBL2945580 | 0.80 | ALDH1A1 (0.48) | FOLH1DCLRE1BDCLRE1AALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109438414-B | Method for preparing benzo 1, 3-oxathiane-4-ketone | 常州大学 | 2021-03-16 | — | — | CN | claimed |
| US-7220780-B2 | Naaladase inhibitors for treating retinal disorders and glaucoma | GUILFORD PHARMACEUTICALS INC. (US) | 2007-05-22 | — | — | US | claimed |
| US-20040186081-A1 | Naaladase inhibitors for treating opioid tolerance | GUILFORD PHARMACEUTICALS INC. | 2004-09-23 | — | — | US | claimed |
| WO-2004078180-A2 | NAALADASE INHIBITORS FOR TREATING OPIOID TOLERANCE | GUILFORD PHARMACEUTICALS INC. (US) | 2004-09-16 | — | — | WO | claimed |
| EP-1292601-A2 | NAALADASE INHIBITORS FOR TREATING RETINAL DISORDERS AND GLAUCOMA | GUILFORD PHARMACEUTICALS INC. (US) | 2003-03-19 | — | — | EP | claimed |
| US-20030036534-A1 | Naaladase inhibitors for treating retinal disorders and glaucoma | EISAI INC. | 2003-02-20 | — | — | US | claimed |
| WO-2001092274-A2 | NAALADASE INHIBITORS FOR TREATING RETINAL DISORDERS AND GLAUCOMA | GUILFORD PHARMACEUTICALS INC. (US) | 2001-12-06 | — | — | WO | claimed |
| US-4826888-A | STORAGE STABLE, DISCOLORATION INHIBITION | MITSUBISHI RAYON CO., LTD. (JP) | 1989-05-02 | — | — | US | claimed |
| CN-117866042-A | Disulfide-containing cell penetrating peptides and methods of making and using the same | 俄亥俄州国家创新基金会 | 2024-04-12 | — | — | CN | disclosed |
| CN-110114075-B | Disulfide-containing cell penetrating peptides and methods of making and using the same | 俄亥俄州国家创新基金会 | 2024-01-12 | — | — | CN | disclosed |
| CN-116920127-A | Stimulus-responsive self-assembled magnetic resonance contrast agent drug-loading system and preparation method thereof | 浙江省肿瘤医院 | 2023-10-24 | — | — | CN | disclosed |
| CN-116125066-A | Stimulus response type magnetic SERS composite nano probe and preparation method and application thereof | 浙江省肿瘤医院 | 2023-05-16 | — | — | CN | disclosed |
| WO-2021131845-A1 | RADIATION-SENSITIVE RESIN COMPOSITION AND METHOD FOR FORMING PATTERN | JSR株式会社 | 2021-07-01 | — | — | WO | disclosed |
| CN-109438414-B | Method for preparing benzo 1, 3-oxathiane-4-ketone | 常州大学 | 2021-03-16 | — | — | CN | disclosed |
| US-5204358-A | Antiallergens; antiinflammatory agents; treatment of asthma, rhinitis, bronchitis and skin diseases | MERCK FROSST CANADA, INC. (CA) | 1993-04-20 | — | — | US | disclosed |
| US-5104882-A | Leukotriene antagonists | MERCK FROSST CANADA, INC. (CA) | 1992-04-14 | — | — | US | disclosed |
| US-5021491-A | Heat stabilizers for thermoplastic chloropolymers | CIBA-GEIGY CORPORATION (US) | 1991-06-04 | — | — | US | disclosed |
| EP-0399818-A1 | Diarylstyrylquinoline diacids | MERCK FROSST CANADA INC. (CA) | 1990-11-28 | — | — | EP | disclosed |
| US-4298455-A | VISBREAKING HEAVY OIL IN PRESENCE OF CHAIN TRANSFER AGENT AND FREE RADICAL INITIATOR | TEXACO INC. (US) | 1981-11-03 | — | — | US | disclosed |
| US-3931231-A | FUNGICIDE, BACTERICIDE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186081-A1 | Naaladase inhibitors for treating opioid tolerance | OPRD1, OPRK1, OPRM1 | FOLH1 254/4885DCLRE1B 2180/4885DCLRE1A 4544/4885 |
| US-20030036534-A1 | Naaladase inhibitors for treating retinal disorders and glaucoma | ALDH1A2, GAA, PDE6A | FOLH1 124/4885DCLRE1B 1243/4885DCLRE1A 3165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.