Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.46 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.46 |
| ▸ | ITGAL | P20701 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CRHBP | P24387 | 2/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30395562 | 1.00 | NOTUM (0.51) | NOTUMITGB2ICAM1ITGALPDK1 | |
| SCHEMBL5636855 | 0.89 | NOTUM (0.45) | NOTUMITGB2ICAM1ITGALPDK1 | |
| SCHEMBL2362807 | 0.77 | ALDH1A1 (0.54) | NOTUMKMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL3220133 | 0.76 | FABP6 (0.39) | POLBHTTMAPT | |
| SCHEMBL18650412 | 0.75 | ALDH1A1 (0.40) | NOTUMKMT2ASMN1; SMN2NPC1TSHR | |
| SCHEMBL11434536 | 0.73 | HTR2A (0.44) | NOTUMITGB2ICAM1ITGALPDK1 | |
| SCHEMBL11430346 | 0.73 | ALOX12 (0.42) | NOTUMTSHR | |
| SCHEMBL6502052 | 0.71 | ALDH1A1 (0.37) | NOTUMPOLBKMT2ANPC1TSHR | |
| SCHEMBL214286 | 0.71 | NOTUM (0.56) | NOTUMITGB2ICAM1ITGALPDK1 | |
| SCHEMBL519320 | 0.71 | NOTUM (0.56) | NOTUMITGB2ICAM1ITGALPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12312356-B2 | Anthelmintic heterocyclic compounds | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2025-05-27 | — | — | US | disclosed |
| EP-4426699-A1 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | Boehringer Ingelheim Vetmedica GmbH (DE) | 2024-09-11 | — | — | EP | disclosed |
| US-20240254133-A1 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2024-08-01 | — | — | US | disclosed |
| CN-118339164-A | Insect repellent pyrrolopyridazine compounds | 勃林格殷格翰动物保健有限公司 | 2024-07-12 | — | — | CN | disclosed |
| US-11999742-B2 | Substituted pyrrolo[1,2-b]pyridazines as anthelmintics | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2024-06-04 | — | — | US | disclosed |
| US-20240166653-A1 | ANTHELMINTIC HETEROCYCLIC COMPOUNDS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2024-05-23 | — | — | US | disclosed |
| US-11964977-B2 | Anthelmintic heterocyclic compounds | Boehringer Ingelheim Animal Health USA Inc. (US) | 2024-04-23 | — | — | US | disclosed |
| CN-116249704-A | Heterocyclic compounds for insect repellent | 勃林格殷格翰动物保健美国公司 | 2023-06-09 | — | — | CN | disclosed |
| EP-4185589-A1 | ANTHELMINTIC HETEROCYCLIC COMPOUNDS | Boehringer Ingelheim Animal Health USA Inc. (US) | 2023-05-31 | — | — | EP | disclosed |
| US-20230159543-A1 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2023-05-25 | — | — | US | disclosed |
| US-9949965-B2 | Tricyclic indole Mcl-1 inhibitors and uses thereof | VANDERBILT UNIVERSITY (US) | 2018-04-24 | — | — | US | disclosed |
| US-20160106731-A1 | TRICYCLIC INDOLE MCL-1 INHIBITORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-04-21 | — | — | US | disclosed |
| US-9193728-B2 | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193728-B2 | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193728-B2 | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-20130210803-A1 | FUSED TETRACYCLIC PYRIDO [4,3-B] INDOLE AND PYRIDO [3,4-B] INDOLE DERIVATIVES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. | 2013-08-15 | — | — | US | disclosed |
| US-20130210803-A1 | FUSED TETRACYCLIC PYRIDO [4,3-B] INDOLE AND PYRIDO [3,4-B] INDOLE DERIVATIVES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. | 2013-08-15 | — | — | US | disclosed |
| US-20130210803-A1 | FUSED TETRACYCLIC PYRIDO [4,3-B] INDOLE AND PYRIDO [3,4-B] INDOLE DERIVATIVES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. | 2013-08-15 | — | — | US | disclosed |
| WO-2011103460-A1 | FUSED TETRACYCLIC PYRIDO[4,3-B]INDOLE AND PYRIDO[3,4-B]ONDOLE DERIVATIVES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2011-08-25 | — | — | WO | disclosed |
| WO-2011103460-A1 | FUSED TETRACYCLIC PYRIDO[4,3-B]INDOLE AND PYRIDO[3,4-B]ONDOLE DERIVATIVES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2011-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11964977-B2 | Anthelmintic heterocyclic compounds | AADAC, HNMT, HRH4 | NOTUM 465/4885ITGB2 3597/4885ICAM1 3809/4885 |
| US-20230159543-A1 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | IL5, EPX, MPO | NOTUM 454/4885ITGB2 4197/4885ICAM1 3325/4885 |
| US-20240166653-A1 | ANTHELMINTIC HETEROCYCLIC COMPOUNDS | AADAC, HNMT, HRH4 | NOTUM 465/4885ITGB2 3597/4885ICAM1 3809/4885 |
| US-12312356-B2 | Anthelmintic heterocyclic compounds | AADAC, HNMT, HRH4 | NOTUM 465/4885ITGB2 3597/4885ICAM1 3809/4885 |
| US-20130210803-A1 | FUSED TETRACYCLIC PYRIDO [4,3-B] INDOLE AND PYRIDO [3,4-B] INDOLE DERIVATIVES AND METHODS OF USE | HTR4, HTR3B, HTR2C | NOTUM 3665/4885ITGB2 4230/4885ICAM1 3400/4885 |
| US-20240254133-A1 | ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS | IL5, EPX, MPO | NOTUM 454/4885ITGB2 4197/4885ICAM1 3325/4885 |
| US-20160106731-A1 | TRICYCLIC INDOLE MCL-1 INHIBITORS AND USES THEREOF | MCL1, BCL2L1, BCL3 | NOTUM 4292/4885ITGB2 4691/4885ICAM1 1725/4885 |
| US-11999742-B2 | Substituted pyrrolo[1,2-b]pyridazines as anthelmintics | IL5, PLPBP, PNPO | NOTUM 1972/4885ITGB2 2245/4885ICAM1 2808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.