SCHEMBL2368577

SCHEMBL2368577

Oc1cc2cc(O)c(Br)cc2cc1Br

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.46
GPR35 Q9HC97 2/20 0.39
CYP3A4 P08684 1/20 0.38
TSHR P16473 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
LMNA P02545 1/20 0.37
PRNP P04156 1/20 0.37
HPGD P15428 1/20 0.37
HTT P42858 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
NOD2 Q9HC29 1/20 0.37
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA4 P22748 1/20 0.35
CA6 P23280 1/20 0.35
GABRA1 P14867 1/20 0.33
GABRB1 P18505 1/20 0.33
GABRA2 P47869 1/20 0.33
GABRB2 P47870 1/20 0.33
KDM1A O60341 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29705950 1.00 ALOX15 (0.46) ALOX15GPR35CYP3A4TSHRTDP1
SCHEMBL29705988 1.00 ALOX15 (0.46) ALOX15GPR35CYP3A4TSHRTDP1
SCHEMBL2367985 1.00 ALOX15 (0.46) ALOX15GPR35CYP3A4TSHRTDP1
SCHEMBL28853956 0.97 ALOX15 (0.43) ALOX15GPR35CYP3A4TSHRTDP1
SCHEMBL30311029 0.87 ALOX15 (0.39) ALOX15GPR35CYP3A4TSHRTDP1
SCHEMBL6357305 0.87 ALOX15 (0.39) ALOX15GPR35CYP3A4TSHRTDP1
SCHEMBL14231760 0.84 TRPM4 (0.43) ALOX15CYP3A4TDP1HPGDNQO2
SCHEMBL1068304 0.83 TRPM4 (0.46) ALOX15CYP3A4TDP1LMNAHPGD
SCHEMBL29748797 0.83 TRPM4 (0.46) ALOX15CYP3A4TDP1LMNAHPGD
SCHEMBL23643819 0.83 CYP1A2 (0.50) ALOX15CYP3A4TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115057762-B Aggregation-resistant induced quenching type rigid Gemini fluorescent amphiphilic molecule and synthesis method thereof 武汉大学 2023-09-08 CN claimed
CN-115057762-A Aggregation-induced quenching-resistant rigid Gemini fluorescent amphiphilic molecule and synthesis method thereof 武汉大学 2022-09-16 CN claimed
US-12004419-B2 Electroactive compounds LG CHEM, LTD. (KR) 2024-06-04 US disclosed
US-11912646-B2 Transmembrane pores formed by aromatic oligoamide foldamers and uses of same THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2024-02-27 US disclosed
US-11912646-B2 Transmembrane pores formed by aromatic oligoamide foldamers and uses of same THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2024-02-27 US disclosed
CN-115057762-B Aggregation-resistant induced quenching type rigid Gemini fluorescent amphiphilic molecule and synthesis method thereof 武汉大学 2023-09-08 CN disclosed
CN-116348455-A Protein tyrosine phosphatase inhibitors and methods of use thereof 卡里科生命科学有限责任公司 2023-06-27 CN disclosed
CN-111194320-B Polycyclic compound and organic light-emitting element comprising same 株式会社LG化学 2023-04-04 CN disclosed
US-11618757-B2 Polycyclic compound and organic light emitting element comprising same LG CHEM, LTD. (KR) 2023-04-04 US disclosed
US-20230019236-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF CALICO LIFE SCIENCES LLC (US) 2023-01-19 US disclosed
CN-115057762-A Aggregation-induced quenching-resistant rigid Gemini fluorescent amphiphilic molecule and synthesis method thereof 武汉大学 2022-09-16 CN disclosed
US-20110224445-A1 Novel Compound, Method of Producing the Compound, Organic Semiconductor Material and Organic Semiconductor Device HIROSHIMA UNIVERSITY (JP) 2011-09-15 US disclosed
US-20110224445-A1 Novel Compound, Method of Producing the Compound, Organic Semiconductor Material and Organic Semiconductor Device HIROSHIMA UNIVERSITY (JP) 2011-09-15 US disclosed
US-20110224445-A1 Novel Compound, Method of Producing the Compound, Organic Semiconductor Material and Organic Semiconductor Device HIROSHIMA UNIVERSITY (JP) 2011-09-15 US disclosed
WO-2010058692-A1 NOVEL COMPOUND, PROCESS FOR PRODUCING THE COMPOUND, ORGANIC SEMICONDUCTOR MATERIAL, AND ORGANIC SEMICONDUCTOR DEVICE 国立大学法人広島大学 (JP) 2010-05-27 WO disclosed
US-20100035942-A1 1-orthofluorophenyl substituted 1,2,5-thiazolidinedione derivatives as ptp-as inhibitors NOVARTIS AG (CH) 2010-02-11 US disclosed
US-20090166590-A1 FUSED THIOPHENE ACENES AND ORGANIC SEMICONDUCTORS MADE THEREFROM E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-07-02 US disclosed
US-20090166590-A1 FUSED THIOPHENE ACENES AND ORGANIC SEMICONDUCTORS MADE THEREFROM E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-07-02 US disclosed
EP-1963293-A1 1-ORTHOFLUOROPHENYL SUBSTITUTED 1, 2 , 5-THIAZOLIDINEDIONE DERIVATIVES AS PTP-AS INHIBITORS Novartis AG (CH) 2008-09-03 EP disclosed
WO-2007067612-A1 1-ORTHOFLUOROPHENYL SUBSTITUTED 1, 2, 5-THIAZOLIDINEDIONE DERIVATIVES AS PTP-AS INHIBITORS NOVARTIS AG (CH) 2007-06-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230019236-A1 PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF PTPN1, PTPN2, PTPN18 ALOX15 4161/4885GPR35 3589/4885CYP3A4 4379/4885
US-11912646-B2 Transmembrane pores formed by aromatic oligoamide foldamers and uses of same AQP1, STOM, SLC22A8 ALOX15 3725/4885GPR35 1297/4885CYP3A4 4423/4885
US-11618757-B2 Polycyclic compound and organic light emitting element comprising same CRY1, CRY2, PER2 ALOX15 459/4885GPR35 3011/4885CYP3A4 31/4885
US-12004419-B2 Electroactive compounds KCNN3, KCNN2, HCN3 ALOX15 1217/4885GPR35 1105/4885CYP3A4 322/4885
US-20100035942-A1 1-orthofluorophenyl substituted 1,2,5-thiazolidinedione derivatives as ptp-as inhibitors PTPRS, PTPRF, PTPRO ALOX15 427/4885GPR35 761/4885CYP3A4 3567/4885
US-20090166590-A1 FUSED THIOPHENE ACENES AND ORGANIC SEMICONDUCTORS MADE THEREFROM ACE2, ACE, DDT ALOX15 827/4885GPR35 2296/4885CYP3A4 1605/4885
US-20110224445-A1 Novel Compound, Method of Producing the Compound, Organic Semiconductor Material and Organic Semiconductor Device TST, SCLY, SELENOI ALOX15 3100/4885GPR35 3640/4885CYP3A4 318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.