Dermorphin

Dermorphin

SCHEMBL237169

C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 5/20 0.73
OPRD1 P41143 5/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29972771 0.95 OPRM1 (0.80) OPRM1OPRD1
SCHEMBL29973283 0.95 OPRM1 (0.80) OPRM1OPRD1
SCHEMBL31303185 0.94 OPRM1 (0.78) OPRM1OPRD1
SCHEMBL30294044 0.93 OPRM1 (0.77) OPRM1OPRD1
SCHEMBL11065582 0.87 OPRD1 (0.67) OPRM1OPRD1
SCHEMBL26342858 0.87 OPRM1 (0.72) OPRM1OPRD1
SCHEMBL22545413 0.87 OPRM1 (0.60) OPRM1OPRD1
SCHEMBL29590990 0.87 OPRM1 (0.67) OPRM1OPRD1
SCHEMBL11069657 0.86 OPRD1 (0.65) OPRM1OPRD1
SCHEMBL11059764 0.86 OPRD1 (0.68) OPRM1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1212 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026090085-A1 TREATMENT OF CD33 RELATED DISEASES AND DISORDERS EMPIRICO INC. (US) 2026-04-30 WO claimed
US-12478585-B2 Micelles and vesicles for the delivery of glycopeptides ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2025-11-25 US claimed
US-12297227-B2 Method for extracting target protein from biological sample and method for analyzing target protein MEDIFORD CORPORATION (JP) 2025-05-13 US claimed
US-12139455-B2 Polyethylene glycol derivative and use thereof HANMI PHARM. CO., LTD. (KR) 2024-11-12 US claimed
CN-118209669-A Solid phase extraction-liquid chromatography-mass spectrometry detection method for small peptide substances in dry blood spots 北京体育大学 2024-06-18 CN claimed
US-20230212103-A1 POLYETHYLENE GLYCOL DERIVATIVE AND USE THEREOF HANMI PHARM. CO., LTD. (KR) 2023-07-06 US claimed
EP-3475417-B1 COMPOSITIONS AND METHODS FOR MAKING BENZYLISOQUINOLINE ALKALOIDS, MORPHINAN ALKALOIDS, THEBAINE, AND DERIVATIVES THEREOF ANTHEIA INC (US) 2023-05-24 EP claimed
US-20230139745-A1 NON-PEPTIDIC POLYMERIC LINKER COMPOUND, CONJUGATE COMPRISING SAME LINKER COMPOUND, AND METHODS FOR PREPARING SAME LINKER COMPOUND AND CONJUGATE HANMI PHARM. CO., LTD. (KR) 2023-05-04 US claimed
US-20230104480-A1 MICELLES AND VESICLES FOR THE DELIVERY OF GLYCOPEPTIDES ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA 2023-04-06 US claimed
US-11603346-B2 Polyethylene glycol derivative and use thereof HANMI PHARM. CO., LTD. (KR) 2023-03-14 US claimed
US-20010038862-A1 Topical and transdermal administration of peptidyl durgs using hydroxide releasing agents as permeation enhancers TECHNOLOGY RECOVERY SYSTEMS, LLC 2001-11-08 US claimed
WO-2001039791-A2 TYROSINE- AND TRYPTOPHAN-CONTAINING PEPTIDES AS ANTIOXIDANTS MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2001-06-07 WO claimed
US-6225100-B1 ENZYME FROM CLOSTRIDIUM WITH STORAGE AND REACTION STABILITY; FOR EFFICIENT SULFATION OF TYROSYLPEPTIDES SUCH AS CHOLECYSTOKININ DCV, INC. 2001-05-01 US claimed
WO-1998003636-A9 NOVEL ARYLSULFOTRANSFERASE 1998-05-22 WO claimed
WO-1998003636-A1 NOVEL ARYLSULFOTRANSFERASE BIO-TECHNICAL RESOURCES (US) 1998-01-29 WO claimed
EP-0820466-A2 FLUORESCENT PEPTIDES Advanced Bioconcept Inc. (CA) 1998-01-28 EP claimed
WO-1997004311-A2 CELL SORTING WITH FLUORESCENT PEPTIDES ADVANCED BIOCONCEPT, INC. (CA) 1997-02-06 WO claimed
US-5572025-A Method and apparatus for scanning an ion trap mass spectrometer in the resonance ejection mode THE JOHNS HOPKINS UNIVERSITY, SCHOOL OF MEDICINE (US) 1996-11-05 US claimed
WO-1996031531-A2 FLUORESCENT PEPTIDES ADVANCED BIOCONCEPT, INC. (CA) 1996-10-10 WO claimed
WO-1991008220-A1 A METHOD FOR THE STEPWISE, CONTROLLED SYNTHESIS OF CHEMICAL SPECIES, PARTICULARLY PEPTIDES, COUPLED PRODUCTS OBTAINED BY THE METHOD AND THE USE OF THESE COUPLED PRODUCTS, E.G. AS VACCINES HOUEN GUNNAR (DK) 1991-06-13 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11603346-B2 Polyethylene glycol derivative and use thereof UGCG, NAPEPLD, CD44 OPRM1 2930/4885OPRD1 2067/4885
US-12139455-B2 Polyethylene glycol derivative and use thereof RPN2, MPDU1, RPN1 OPRM1 3014/4885OPRD1 1556/4885
US-12478585-B2 Micelles and vesicles for the delivery of glycopeptides CHMP4B, MUC1, EXOSC4 OPRM1 3730/4885OPRD1 4443/4885
US-20230139745-A1 NON-PEPTIDIC POLYMERIC LINKER COMPOUND, CONJUGATE COMPRISING SAME LINKER COMPOUND, AND METHODS FOR PREPARING SAME LINKER COMPOUND AND CONJUGATE FCGR1A, FCGR3B, FCGR2A OPRM1 4343/4885OPRD1 4706/4885
US-20230104480-A1 MICELLES AND VESICLES FOR THE DELIVERY OF GLYCOPEPTIDES CHMP4B, MUC1, EXOSC4 OPRM1 3730/4885OPRD1 4443/4885
US-20230212103-A1 POLYETHYLENE GLYCOL DERIVATIVE AND USE THEREOF RPN2, MPDU1, RPN1 OPRM1 3014/4885OPRD1 1556/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.