Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.57 |
| ▸ | DHODH | Q02127 | 6/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | EIF4A1 | P60842 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23752064 | 0.97 | PLA2G2A (0.60) | PLA2G2ADHODHPDE10AEIF4A1ALDH1A1 | |
| SCHEMBL29617659 | 0.91 | DHODH (0.64) | PLA2G2ADHODHPDE10AEIF4A1ALDH1A1 | |
| SCHEMBL29617651 | 0.91 | DHODH (0.64) | PLA2G2ADHODHPDE10AEIF4A1ALDH1A1 | |
| SCHEMBL29617654 | 0.91 | DHODH (0.64) | PLA2G2ADHODHPDE10AEIF4A1ALDH1A1 | |
| SCHEMBL23113786 | 0.91 | DHODH (0.64) | PLA2G2ADHODHPDE10AEIF4A1ALDH1A1 | |
| SCHEMBL23590074 | 0.91 | DHODH (0.64) | PLA2G2ADHODHPDE10AEIF4A1ALDH1A1 | |
| SCHEMBL23590072 | 0.91 | DHODH (0.64) | PLA2G2ADHODHPDE10AEIF4A1ALDH1A1 | |
| SCHEMBL23590083 | 0.91 | DHODH (0.64) | PLA2G2ADHODHPDE10AEIF4A1ALDH1A1 | |
| SCHEMBL23590073 | 0.90 | DHODH (0.66) | PLA2G2ADHODHPDE10AEIF4A1ALDH1A1 | |
| SCHEMBL29617661 | 0.90 | DHODH (0.66) | PLA2G2ADHODHPDE10AEIF4A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4438042-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | Ohio State Innovation Foundation (US) | 2024-10-02 | — | — | EP | disclosed |
| US-20240294477-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | OHIO STATE INNOVATION FOUNDATION (US) | 2024-09-05 | — | — | US | disclosed |
| EP-3793562-B1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | OHIO STATE INNOVATION FOUNDATION (US) | 2024-06-19 | — | — | EP | disclosed |
| US-11999697-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | OHIO STATE INNOVATION FOUNDATION (US) | 2024-06-04 | — | — | US | disclosed |
| US-11312686-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | OHIO STATE INNOVATION FOUNDATION (US) | 2022-04-26 | — | — | US | disclosed |
| US-20220064119-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | HENDRIX COLLEGE | 2022-03-03 | — | — | US | disclosed |
| US-20210253531-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | OHIO STATE INNOVATION FOUNDATION | 2021-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312686-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | DHODH, DLD, DPYD | PLA2G2A 3822/4885DHODH 1/4885PDE10A 3865/4885 |
| US-20240294477-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | DHODH, DLD, DPYD | PLA2G2A 3651/4885DHODH 1/4885PDE10A 3520/4885 |
| US-20220064119-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | DHODH, DLD, DPYD | PLA2G2A 3651/4885DHODH 1/4885PDE10A 3520/4885 |
| US-20210253531-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | DHODH, DLD, DPYD | PLA2G2A 3822/4885DHODH 1/4885PDE10A 3865/4885 |
| US-11999697-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | DHODH, DLD, DPYD | PLA2G2A 3651/4885DHODH 1/4885PDE10A 3520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.