SCHEMBL2376785

SCHEMBL2376785

COc1cc(CCC(=O)NCCc2ccc(O)cc2)ccc1O

nearest known ligand 0.72

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.67
KMT2A Q03164 3/20 0.67
ALOX5 P09917 1/20 0.63
OR51E2 Q9H255 1/20 0.63
MTNR1A P48039 1/20 0.57
MTNR1B P49286 1/20 0.57
TRPV1 Q8NER1 1/20 0.57
ALDH1A1 P00352 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1915903 0.95 MEN1 (0.70) MEN1KMT2AALOX5OR51E2MTNR1A
SCHEMBL19060661 0.93 MTNR1A (0.69) MEN1KMT2AALOX5OR51E2MTNR1A
SCHEMBL14432087 0.91 KMT2A (0.66) MEN1KMT2AALOX5OR51E2MTNR1A
SCHEMBL2378930 0.91 MEN1 (0.65) MEN1KMT2AALOX5OR51E2MTNR1A
SCHEMBL23318259 0.89 MEN1 (0.65) MEN1KMT2AALDH1A1
SCHEMBL9921169 0.86 MEN1 (0.60) MEN1KMT2AALOX5OR51E2MTNR1A
SCHEMBL19789513 0.85 MEN1 (0.65) MEN1KMT2AALOX5OR51E2ALDH1A1
SCHEMBL9426051 0.85 CYP1A2 (0.66) ALOX5OR51E2MTNR1AMTNR1BTRPV1
SCHEMBL14703885 0.84 CA1 (0.75) ALOX5OR51E2MTNR1AMTNR1BALDH1A1
Tetrahydrodemethoxycurcumin SCHEMBL29565582 0.84 ALOX5 (0.89) MEN1KMT2AALOX5OR51E2MTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11642323-B2 Method for modulating metabolism BRIGHTSEED, INC. (US) 2023-05-09 US disclosed
US-9089499-B2 Para-coumaric acid or para-hydroxycinnamic acid derivatives and their use in cosmetic or dermatological compositions UNIVERSITE JOSEPH FOURIER-GRENOBLE 1 (FR) 2015-07-28 US disclosed
US-9089499-B2 Para-coumaric acid or para-hydroxycinnamic acid derivatives and their use in cosmetic or dermatological compositions UNIVERSITE JOSEPH FOURIER-GRENOBLE 1 (FR) 2015-07-28 US disclosed
US-20130272983-A1 Para-Coumaric Acid or Para-Hydroxycinnamic Acid Derivatives and their Use in Cosmetic or Dermatological Compositions Universite Joseph Fourier-Grenoble 1. (FR) 2013-10-17 US disclosed
US-20130272983-A1 Para-Coumaric Acid or Para-Hydroxycinnamic Acid Derivatives and their Use in Cosmetic or Dermatological Compositions Universite Joseph Fourier-Grenoble 1. (FR) 2013-10-17 US disclosed
US-8481593-B2 Para-coumaric acid or para-hydroxycinnamic acid derivatives and their use in cosmetic or dermatological compositions BASF BEAUTY CARE SOLUTIONS S.A.S. (FR) 2013-07-09 US disclosed
US-8481593-B2 Para-coumaric acid or para-hydroxycinnamic acid derivatives and their use in cosmetic or dermatological compositions BASF BEAUTY CARE SOLUTIONS S.A.S. (FR) 2013-07-09 US disclosed
US-20110237551-A1 Para-Coumaric Acid or Para-Hydroxycinnamic Acid Derivatives and Their Use in Cosmetic or Dermatological Compositions BASF BEAUTY CARE SOLUTIONS FRANCE S.A.S. (FR) 2011-09-29 US disclosed
US-20110237551-A1 Para-Coumaric Acid or Para-Hydroxycinnamic Acid Derivatives and Their Use in Cosmetic or Dermatological Compositions BASF BEAUTY CARE SOLUTIONS FRANCE S.A.S. (FR) 2011-09-29 US disclosed
US-20070183996-A1 Para-coumaric acid or para-hydroxycinnamic acid derivatives and their use in cosmetic or dermatological compositions BASF BEAUTY CARE SOLUTIONS FRANCE S.A.S. (FR) 2007-08-09 US disclosed
US-20070183996-A1 Para-coumaric acid or para-hydroxycinnamic acid derivatives and their use in cosmetic or dermatological compositions BASF BEAUTY CARE SOLUTIONS FRANCE S.A.S. (FR) 2007-08-09 US disclosed
US-20070183996-A1 Para-coumaric acid or para-hydroxycinnamic acid derivatives and their use in cosmetic or dermatological compositions BASF BEAUTY CARE SOLUTIONS FRANCE S.A.S. (FR) 2007-08-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11642323-B2 Method for modulating metabolism GOT2, GYS2, PC MEN1 3891/4885KMT2A 2636/4885ALOX5 670/4885
US-20110237551-A1 Para-Coumaric Acid or Para-Hydroxycinnamic Acid Derivatives and Their Use in Cosmetic or Dermatological Compositions TYR, CUTA, HPD MEN1 3977/4885KMT2A 2137/4885ALOX5 264/4885
US-20070183996-A1 Para-coumaric acid or para-hydroxycinnamic acid derivatives and their use in cosmetic or dermatological compositions TYR, CUTA, HPD MEN1 3994/4885KMT2A 2090/4885ALOX5 265/4885
US-20130272983-A1 Para-Coumaric Acid or Para-Hydroxycinnamic Acid Derivatives and their Use in Cosmetic or Dermatological Compositions TYR, CUTA, HPD MEN1 3994/4885KMT2A 2090/4885ALOX5 265/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.