Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 8/20 | 0.32 |
| ▸ | CNR2 | P34972 | 5/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770819 | 0.91 | HTR3A (0.41) | PTPN11 | |
| SCHEMBL23770739 | 0.88 | CNR2 (0.38) | PTPN11CNR2MAPK3MAPK1 | |
| SCHEMBL23770475 | 0.87 | L3MBTL1 (0.39) | CNR2MAPK1MAOBCNR1L3MBTL1 | |
| SCHEMBL23770499 | 0.85 | PTPN11 (0.36) | PTPN11MAPK3MAPK1 | |
| SCHEMBL23770731 | 0.82 | HTR3A (0.40) | PTPN11NPC1 | |
| SCHEMBL23770606 | 0.80 | ADRB2 (0.43) | PTPN11CNR2MAPK3MAPK1 | |
| SCHEMBL23770837 | 0.80 | SMO (0.34) | CNR2CNR1L3MBTL1 | |
| SCHEMBL23770669 | 0.79 | HTR3A (0.40) | PTPN11 | |
| SCHEMBL23770850 | 0.78 | LRRK2 (0.33) | — | |
| SCHEMBL23770862 | 0.76 | HTR3E (0.42) | PTPN11MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |