SCHEMBL2378671

SCHEMBL2378671

CC(C)c1cccc(C(C)C)c1Nc1ccc(Nc2c(C(C)C)cccc2C(C)C)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.47
LMNA P02545 3/20 0.46
CYP3A4 P08684 3/20 0.46
GABRA1 P14867 3/20 0.46
CYP1A2 P05177 2/20 0.46
GABRG2 P18507 2/20 0.46
GABRB3 P28472 2/20 0.46
TSHR P16473 2/20 0.46
GABRB2 P47870 2/20 0.46
FAAH O00519 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
HPGD P15428 1/20 0.46
GABRB1 P18505 1/20 0.46
PTGS1 P23219 1/20 0.46
SLC6A2 P23975 1/20 0.46
HTR2C P28335 1/20 0.46
GABRA5 P31644 1/20 0.46
GABRA3 P34903 1/20 0.46
HTR2B P41595 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4808803 0.92 RAPGEF4 (0.48) HDAC6LMNACYP3A4GABRA1CYP1A2
SCHEMBL5025966 0.91 LMNA (0.50) HDAC6LMNACYP3A4GABRA1CYP1A2
SCHEMBL2545467 0.90 KCNH3 (0.42) HDAC6LMNACYP3A4GABRA1CYP1A2
SCHEMBL812723 0.87 GABRA1 (0.52) LMNACYP3A4GABRA1CYP1A2GABRG2
SCHEMBL12071030 0.87 ALDH1A1 (0.61) LMNAHPGDKDM1AKMT2ASMN1; SMN2
SCHEMBL3628547 0.86 KMT2A (0.53) HDAC6LMNACYP3A4GABRA1CYP1A2
SCHEMBL18458442 0.85 HDAC6 (0.54) HDAC6LMNAGABRA1HPGDGABRB1
SCHEMBL16583962 0.84 HDAC6 (0.53) HDAC6LMNAHPGDKMT2ASMN1; SMN2
SCHEMBL21763812 0.84 RAPGEF4 (0.42) HDAC6LMNACYP3A4GABRA1CYP1A2
SCHEMBL31447156 0.79 LMNA (0.47) LMNACYP3A4GABRA1CYP1A2GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2144867-B1 LUBRICATING COMPOSITIONS CONTAINING ASHLESS CATALYTIC ANTIOXIDANT ADDITIVES EXXONMOBIL RES & ENG CO (US) 2013-01-16 EP claimed
US-8017806-B2 Lubricating compositions containing ashless catalytic antioxidant additives EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2011-09-13 US claimed
EP-2144867-A1 LUBRICATING COMPOSITIONS CONTAINING ASHLESS CATALYTIC ANTIOXIDANT ADDITIVES ExxonMobil Research and Engineering Company (US) 2010-01-20 EP claimed
US-7586007-B2 Lubricating compositions containing ashless catalytic antioxidant additives EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2009-09-08 US claimed
WO-2008123941-A1 LUBRICATING COMPOSITIONS CONTAINING ASHLESS CATALYTIC ANTIOXIDANT ADDITIVES EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2008-10-16 WO claimed
US-20080245336-A1 Lubricating compositions containing ashless catalytic antioxidant additives EXXONMOBIL RESEARCH AND ENGINEERING COMPANY 2008-10-09 US claimed
EP-2144867-B1 LUBRICATING COMPOSITIONS CONTAINING ASHLESS CATALYTIC ANTIOXIDANT ADDITIVES EXXONMOBIL RES & ENG CO (US) 2013-01-16 EP disclosed
US-8017806-B2 Lubricating compositions containing ashless catalytic antioxidant additives EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2011-09-13 US disclosed
EP-2144867-A1 LUBRICATING COMPOSITIONS CONTAINING ASHLESS CATALYTIC ANTIOXIDANT ADDITIVES ExxonMobil Research and Engineering Company (US) 2010-01-20 EP disclosed
US-20090287022-A1 Lubricating compositions containing ashless catalytic antioxidant additives PATIL ABHIMANYU O 2009-11-19 US disclosed
US-7586007-B2 Lubricating compositions containing ashless catalytic antioxidant additives EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2009-09-08 US disclosed
WO-2008123941-A1 LUBRICATING COMPOSITIONS CONTAINING ASHLESS CATALYTIC ANTIOXIDANT ADDITIVES EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2008-10-16 WO disclosed
US-20080245336-A1 Lubricating compositions containing ashless catalytic antioxidant additives EXXONMOBIL RESEARCH AND ENGINEERING COMPANY 2008-10-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080245336-A1 Lubricating compositions containing ashless catalytic antioxidant additives GPX1, GPX4, SOD1 HDAC6 802/4885LMNA 3798/4885CYP3A4 2208/4885
US-20090287022-A1 Lubricating compositions containing ashless catalytic antioxidant additives GPX1, GPX4, SOD1 HDAC6 802/4885LMNA 3798/4885CYP3A4 2208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.