Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Azelaic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.53 |
| ▸ | PPARG | P37231 | 6/20 | 0.52 |
| ▸ | PPARD | Q03181 | 6/20 | 0.52 |
| ▸ | PPARA | Q07869 | 6/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TLR2 | O60603 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | FABP4 | P15090 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sebacic Acid SCHEMBL29049531 | 1.00 | TSHR (0.67) | TSHRLMNANFKB1PMP22GPR84 | |
| Azelaic Acid SCHEMBL29070842 | 1.00 | TSHR (0.67) | TSHRLMNANFKB1PMP22GPR84 | |
| Potassium Ion SCHEMBL30384886 | 1.00 | TSHR (0.67) | TSHRLMNANFKB1PMP22GPR84 | |
| Adipic Acid SCHEMBL105192 | 0.97 | LMNA (0.65) | TSHRLMNANFKB1PMP22GPR84 | |
| Sebacic Acid SCHEMBL6135890 | 0.94 | TSHR (0.67) | TSHRLMNANFKB1PMP22GPR84 | |
| Azelaic Acid SCHEMBL31148332 | 0.94 | TSHR (0.67) | TSHRLMNANFKB1PMP22GPR84 | |
| Pimelic Acid SCHEMBL30384892 | 0.94 | TSHR (0.67) | TSHRLMNANFKB1PMP22GPR84 | |
| Azelaic Acid SCHEMBL11445736 | 0.94 | TSHR (0.67) | TSHRLMNANFKB1PMP22GPR84 | |
| Octanedioate SCHEMBL11440382 | 0.94 | TSHR (0.67) | TSHRLMNANFKB1PMP22GPR84 | |
| Octanedioate SCHEMBL9642090 | 0.94 | TSHR (0.67) | TSHRLMNANFKB1PMP22GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3749081-B1 | METHODS AND COMPOSITIONS FOR INCREASING TOLERANCE TO ABIOTIC STRESS IN PLANTS | CROP MICROCLIMATE MAN INC (US) | 2025-05-21 | — | — | EP | disclosed |
| WO-2024177875-A1 | METHODS AND COMPOSITIONS FOR INCREASING TOLERANCE TO ABIOTIC STRESS IN PLANTS | CROP MICROCLIMATE MANAGEMENT INC. (US) | 2024-08-29 | — | — | WO | disclosed |
| US-11638401-B2 | Methods and compositions for increasing tolerance to abiotic stress in plants | CROP MICROCLIMATE MANAGEMENT INC. (US) | 2023-05-02 | — | — | US | disclosed |
| US-20210037717-A1 | METHODS AND COMPOSITIONS FOR INCREASING TOLERANCE TO ABIOTIC STRESS IN PLANTS | CROP MICROCLIMATE MANAGEMENT INC. | 2021-02-11 | — | — | US | disclosed |
| EP-3749081-A1 | METHODS AND COMPOSITIONS FOR INCREASING TOLERANCE TO ABIOTIC STRESS IN PLANTS | Crop Microclimate Management, Inc. (US) | 2020-12-16 | — | — | EP | disclosed |
| WO-2019152632-A1 | METHODS AND COMPOSITIONS FOR INCREASING TOLERANCE TO ABIOTIC STRESS IN PLANTS | CROP MICROCLIMATE MANAGEMENT INC. (US) | 2019-08-08 | — | — | WO | disclosed |
| EP-2549864-B1 | METHODS FOR INCREASING TOLERANCE TO ABIOTIC STRESS IN PLANTS | CROP MICROCLIMATE MAN INC (US) | 2019-01-23 | — | — | EP | disclosed |
| US-10136641-B2 | Methods for increasing tolerance to abiotic stress in plants | CROP MICROCLIMATE MANAGEMENT INC. (US) | 2018-11-27 | — | — | US | disclosed |
| US-20170208800-A1 | Methods for Increasing Tolerance to Abiotic Stress in Plants | CROP MICROCLIMATE MANAGEMENT INC. | 2017-07-27 | — | — | US | disclosed |
| US-9648877-B2 | Methods for increasing tolerance to abiotic stress in plants | CROP MICROCLIMATE MANAGEMENT INC. (US) | 2017-05-16 | — | — | US | disclosed |
| US-20140364314-A1 | METHODS FOR INCREASING TOLERANCE TO ABIOTIC STRESS IN PLANTS | CROP MICROCLIMATE MANAGEMENT INC. | 2014-12-11 | — | — | US | disclosed |
| US-8846573-B2 | Methods for increasing tolerance to abiotic stress in plants | CROP MICROCLIMATE MANAGEMENT INC. (US) | 2014-09-30 | — | — | US | disclosed |
| EP-2549864-A1 | METHODS FOR INCREASING TOLERANCE TO ABIOTIC STRESS IN PLANTS | Crop Microclimate Management, Inc. (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119681-A1 | METHODS FOR INCREASING TOLERANCE TO ABIOTIC STRESS IN PLANTS | CROP MICROCLIMATE MANAGEMENT INC. (US) | 2011-09-29 | — | — | WO | disclosed |
| US-20110232181-A1 | METHODS FOR INCREASING TOLERANCE TO ABIOTIC STRESS IN PLANTS | CROP MICROCLIMATE MANAGEMENT, INC. | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210037717-A1 | METHODS AND COMPOSITIONS FOR INCREASING TOLERANCE TO ABIOTIC STRESS IN PLANTS | HPD, NOS3, HNMT | TSHR 4859/4885LMNA 3002/4885NFKB1 1526/4885 |
| US-11638401-B2 | Methods and compositions for increasing tolerance to abiotic stress in plants | HPD, NOS3, HNMT | TSHR 4859/4885LMNA 3002/4885NFKB1 1526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.