SCHEMBL239465

SCHEMBL239465

O=C1CCN(c2c(F)cc([N+](=O)[O-])cc2F)CC1

nearest known ligand 0.66

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.66
KMT2A Q03164 3/20 0.66
LMNA P02545 3/20 0.40
MAPT P10636 6/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
POLB P06746 3/20 0.39
FAAH O00519 1/20 0.37
MGLL Q99685 1/20 0.37
HIF1A Q16665 1/20 0.36
THRB P10828 1/20 0.36
CYP19A1 P11511 1/20 0.35
MEN1 O00255 2/20 0.35
PKM P14618 1/20 0.35
TDP1 Q9NUW8 2/20 0.35
APEX1 P27695 1/20 0.34
CASP6 P55212 1/20 0.34
CTDSP1 Q9GZU7 1/20 0.34
MAPK1 P28482 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30958108 0.90 ALDH1A1 (0.58) ALDH1A1KMT2ALMNAMAPTSMN1; SMN2
SCHEMBL28196822 0.84 ALDH1A1 (0.46) ALDH1A1KMT2ALMNAMAPTSMN1; SMN2
SCHEMBL18876391 0.83 MAPT (0.51) ALDH1A1KMT2ALMNAMAPTSMN1; SMN2
SCHEMBL4705178 0.83 ALDH1A1 (0.49) ALDH1A1KMT2ALMNAMAPTSMN1; SMN2
SCHEMBL5244666 0.82 ALDH1A1 (0.47) ALDH1A1KMT2ALMNAMAPTSMN1; SMN2
SCHEMBL5242045 0.82 ALDH1A1 (0.47) ALDH1A1KMT2ALMNAMAPTSMN1; SMN2
SCHEMBL28980384 0.81 ALDH1A1 (0.44) ALDH1A1KMT2ALMNAMAPTSMN1; SMN2
SCHEMBL3043208 0.80 ALDH1A1 (0.54) ALDH1A1KMT2ALMNAMAPTSMN1; SMN2
SCHEMBL2450512 0.80 ALDH1A1 (0.59) ALDH1A1KMT2ALMNAMAPTSMN1; SMN2
SCHEMBL22471423 0.80 MAPT (0.59) ALDH1A1KMT2ALMNAMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230285378-A1 Anti-Viral Compounds ABBVIE INC. (US) 2023-09-14 US disclosed
US-20230285378-A1 Anti-Viral Compounds ABBVIE INC. (US) 2023-09-14 US disclosed
US-20230285378-A1 Anti-Viral Compounds ABBVIE INC. (US) 2023-09-14 US disclosed
CN-107567443-B Biaryl derivatives as GPR120 agonists 株式会社LG化学 2023-04-28 CN disclosed
CN-115925679-A Biaryl derivatives as GPR120 agonists 株式会社LG化学 2023-04-07 CN disclosed
EP-3239143-B1 BIARYL DERIVATIVE AS GPR120 AGONIST LG CHEMICAL LTD (KR) 2023-03-22 EP disclosed
US-20220135574-A1 BIARYL DERIVATIVE AS GPR120 AGONIST LG CHEM, LTD. (KR) 2022-05-05 US disclosed
US-11261186-B2 Biaryl derivative as GPR120 agonist LG CHEM. LTD. (KR) 2022-03-01 US disclosed
EP-3438106-A1 ANTI-VIRAL COMPOUNDS AbbVie Ireland Unlimited Company (IE) 2019-02-06 EP disclosed
US-20190015402-A1 Anti-Viral Compounds ABBVIE INC. (US) 2019-01-17 US disclosed
US-20050113347-A1 NOVEL ANTIBACTERIAL COMPOUNDS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S LABORATORIES LIMITED 2005-05-26 US disclosed
WO-2005035528-A2 TRIAZOLE DERIVATIVES AS ANTIBACTERIAL AGENTS DR. REDDY'S LABORATORIES LTD. (IN) 2005-04-21 WO disclosed
US-20050070580-A1 Antimicrobial 1-aryl dihydropyridone compounds GORDEEV MIKHAIL FEDOR (US) 2005-03-31 US disclosed
EP-1478629-A1 N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS PHARMACIA & UPJOHN COMPANY (US) 2004-11-24 EP disclosed
EP-1467977-A1 NOVEL ANTIBACTERIAL COMPOUNDS:PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. Dr. Reddy's Laboratories Ltd. (IN) 2004-10-20 EP disclosed
US-20040147760-A1 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives PHARMACIA & UPJOHN COMPANY 2004-07-29 US disclosed
WO-2004033449-A1 ANTIMICROBIAL 1-ARYL DIHYDROPYRIDONE COMPOUNDS PHARMACIA & UPJOHN COMPANY LLC (US) 2004-04-22 WO disclosed
US-20040044052-A1 N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives PHARMACIA & UPJOHN COMPANY 2004-03-04 US disclosed
WO-2003072553-A1 N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATES AND THEIR USE AS ANTIBACTERIALS PHARMACIA & UPJOHN COMPANY (US) 2003-09-04 WO disclosed
WO-2003059894-A1 NOVEL ANTIBACTERIAL COMPOUNDS:PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. DR.REDDY'S LABORATORIES LTD. (IN) 2003-07-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230285378-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS ALDH1A1 2858/4885KMT2A 4093/4885LMNA 3118/4885
US-20040147760-A1 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives OXA1L, AADAC, MT-ND5 ALDH1A1 956/4885KMT2A 1273/4885LMNA 3385/4885
US-20040044052-A1 N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives OXA1L, AADAC, MT-ND5 ALDH1A1 956/4885KMT2A 1273/4885LMNA 3385/4885
US-20220135574-A1 BIARYL DERIVATIVE AS GPR120 AGONIST GPR119, GLP1R, GIPR ALDH1A1 2174/4885KMT2A 2097/4885LMNA 2785/4885
US-20050070580-A1 Antimicrobial 1-aryl dihydropyridone compounds TLR1, QDPR, AP1S1 ALDH1A1 42/4885KMT2A 4246/4885LMNA 4798/4885
US-20190015402-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS ALDH1A1 2858/4885KMT2A 4093/4885LMNA 3118/4885
US-11261186-B2 Biaryl derivative as GPR120 agonist GPR119, GPR88, FFAR1 ALDH1A1 1152/4885KMT2A 2856/4885LMNA 3243/4885
US-20050113347-A1 NOVEL ANTIBACTERIAL COMPOUNDS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM CYP3A4, CYP3A43, CYP3A5 ALDH1A1 2745/4885KMT2A 4797/4885LMNA 3405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.