SCHEMBL2409855

SCHEMBL2409855

CCO[Si](C)(C)COC(C)=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.50
LMNA P02545 1/20 0.50
HSD17B10 Q99714 1/20 0.50
TSHR P16473 1/20 0.41
CHRM5 P08912 2/20 0.32
CHRM1 P11229 2/20 0.32
CHRM3 P20309 2/20 0.32
PGR P06401 1/20 0.32
CHRM2 P08172 1/20 0.32
CHRM4 P08173 1/20 0.32
HTR1A P08908 1/20 0.32
CHRNB2 P17787 1/20 0.32
TBXA2R P21731 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA7 P36544 1/20 0.32
CHRNA4 P43681 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CHRNA10 Q9GZZ6 1/20 0.32
CHRNA9 Q9UGM1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL960528 0.82 ALDH1A1 (0.50) ALDH1A1LMNAHSD17B10TSHRCHRM5
SCHEMBL81163 0.79 THRB (0.48) ALDH1A1LMNAHSD17B10TSHRGAA
SCHEMBL76913 0.79 ALDH1A1 (0.52) ALDH1A1LMNAHSD17B10TSHRCHRM5
SCHEMBL3338087 0.78 ALDH1A1 (0.48) ALDH1A1LMNAHSD17B10TSHRCHRM5
SCHEMBL4941379 0.78 ALDH1A1 (0.43) ALDH1A1LMNAHSD17B10TSHRCHRM5
SCHEMBL28561857 0.77
SCHEMBL333660 0.77 CA12 (0.32)
SCHEMBL2303044 0.76 ALDH1A1 (0.42) ALDH1A1LMNAHSD17B10TSHRCHRM5
SCHEMBL523852 0.76 ALDH1A1 (0.42) ALDH1A1LMNAHSD17B10TSHRCHRM5
SCHEMBL108961 0.75 TSHR (0.46) ALDH1A1HSD17B10TSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8968458-B2 Composition for resist underlayer film and process for producing same JSR CORPORATION (JP) 2015-03-03 US disclosed
US-8808446-B2 Composition for resist underlayer film and process for producing same JSR CORPORATION (JP) 2014-08-19 US disclosed
EP-2550281-B1 SILAOXACYCLES WACKER CHEMIE AG (DE) 2014-06-25 EP disclosed
EP-2550281-B1 SILAOXACYCLES WACKER CHEMIE AG (DE) 2014-06-25 EP disclosed
US-8722914-B2 Silaoxacycles WACKER CHEMIE AG (DE) 2014-05-13 US disclosed
US-8722914-B2 Silaoxacycles WACKER CHEMIE AG (DE) 2014-05-13 US disclosed
US-8722914-B2 Silaoxacycles WACKER CHEMIE AG (DE) 2014-05-13 US disclosed
US-20130204027-A1 PRODUCTION OF SILAOXACYCLES WACKER CHEMIE AG (DE) 2013-08-08 US disclosed
US-20130204027-A1 PRODUCTION OF SILAOXACYCLES WACKER CHEMIE AG (DE) 2013-08-08 US disclosed
US-20130204027-A1 PRODUCTION OF SILAOXACYCLES WACKER CHEMIE AG (DE) 2013-08-08 US disclosed
US-20130018200-A1 SILAOXACYCLES WACKER CHEMIE AG (DE) 2013-01-17 US disclosed
CN-102822182-A Production of silaoxacyclen WACKER CHEMIE AG 2012-12-12 CN disclosed
WO-2011117072-A1 PRODUCTION OF SILAOXACYCLEN WACKER CHEMIE AG (DE) 2011-09-29 WO disclosed
WO-2011117071-A1 SILAOXACYCLEN WACKER CHEMIE AG (DE) 2011-09-29 WO disclosed
US-20100151384-A1 COMPOSITION FOR RESIST UNDERLAYER FILM AND PROCESS FOR PRODUCING SAME JSR CORPORATION (JP) 2010-06-17 US disclosed
US-20090050020-A1 COMPOSITION FOR RESIST UNDERLAYER FILM AND PROCESS FOR PRODUCING SAME JSR CORPORATION (JP) 2009-02-26 US disclosed
WO-2008054434-A2 POLYMER COMPOSITE WITH SILANE COATED NANOPARTICLES EASTMAN KODAK COMPANY (US) 2008-05-08 WO disclosed
CN-101133364-A Composition for resist underlayer film and method for producing same JSR CORP (JP) 2008-02-27 CN disclosed
EP-1855159-A1 COMPOSITION FOR UNDERLAYER FILM OF RESIST AND PROCESS FOR PRODUCING THE SAME JSR Corporation (JP) 2007-11-14 EP disclosed
US-20070160826-A1 Polymer composite with silane coated nanoparticles EASTMAN KODAK COMPANY 2007-07-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130204027-A1 PRODUCTION OF SILAOXACYCLES OSTC, POLR2E, HAO2 ALDH1A1 1736/4885LMNA 717/4885HSD17B10 3055/4885
US-20130018200-A1 SILAOXACYCLES CCNO, PCNA, CCNA2 ALDH1A1 744/4885LMNA 423/4885HSD17B10 963/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.