Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9570634 | 0.88 | PLA2G2A (0.46) | MAPTLMNAHTTNPC1RAB9A | |
| SCHEMBL5727055 | 0.85 | MAPT (0.40) | MAPTLMNAHTTHSD17B10NPC1 | |
| SCHEMBL6150323 | 0.81 | LTA4H (0.47) | MAPTLMNASMN1; SMN2KDM4EHPGD | |
| SCHEMBL11534430 | 0.80 | DAO (0.33) | NPC1RAB9AGAA | |
| SCHEMBL13946889 | 0.79 | TP53 (0.41) | NPC1RAB9ASMN1; SMN2TP53CYP1A2 | |
| SCHEMBL12869123 | 0.77 | LMNA (0.49) | MAPTLMNANPC1RAB9AL3MBTL1 | |
| SCHEMBL8844670 | 0.77 | LTA4H (0.40) | MAPTHTTL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL2495606 | 0.76 | LMNA (0.62) | MAPTLMNAHTTHSD17B10L3MBTL1 | |
| SCHEMBL8534048 | 0.75 | GRIN1 (0.52) | LTA4H | |
| SCHEMBL6494392 | 0.75 | RAB9A (0.56) | MAPTLMNAHSD17B10NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230201206-A1 | METHODS FOR KILLING ANTIBIOTIC TOLERANT BACTERIA | THE PENN STATE RESEARCH FOUNDATION | 2023-06-29 | — | — | US | disclosed |
| US-20230201206-A1 | METHODS FOR KILLING ANTIBIOTIC TOLERANT BACTERIA | THE PENN STATE RESEARCH FOUNDATION | 2023-06-29 | — | — | US | disclosed |
| US-11654146-B2 | Methods for killing antibiotic tolerant bacteria | THE PENN STATE RESEARCH FOUNDATION (US) | 2023-05-23 | — | — | US | disclosed |
| US-11654146-B2 | Methods for killing antibiotic tolerant bacteria | THE PENN STATE RESEARCH FOUNDATION (US) | 2023-05-23 | — | — | US | disclosed |
| US-11654146-B2 | Methods for killing antibiotic tolerant bacteria | THE PENN STATE RESEARCH FOUNDATION (US) | 2023-05-23 | — | — | US | disclosed |
| US-20210401843-A1 | METHODS FOR KILLING ANTIBIOTIC TOLERANT BACTERIA | THE PENN STATE RESEARCH FOUNDATION | 2021-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11654146-B2 | Methods for killing antibiotic tolerant bacteria | CLPP, SPOUT1, CASP3 | MAPT 4525/4885LMNA 4006/4885HTT 4278/4885 |
| US-20210401843-A1 | METHODS FOR KILLING ANTIBIOTIC TOLERANT BACTERIA | CLPP, SPOUT1, CASP3 | MAPT 4525/4885LMNA 4006/4885HTT 4278/4885 |
| US-20230201206-A1 | METHODS FOR KILLING ANTIBIOTIC TOLERANT BACTERIA | CLPP, SPOUT1, CASP3 | MAPT 4525/4885LMNA 4006/4885HTT 4278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.