Sugi Predict

Sugi Predict / Compounds / SCHEMBL2435536

SCHEMBL2435536

SCHEMBL2435536

O[C@H]1CCc2cc(Br)ccc21

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ SRD5A1 P18405 2/20 0.45
▸ CAMK2A Q9UQM7 1/20 0.45
▸ PGR P06401 1/20 0.42
▸ GFRA3 O60609 1/20 0.41
▸ RET P07949 1/20 0.41
▸ KDM1A O60341 4/20 0.40
▸ SLC6A4 P31645 4/20 0.37
▸ SLC6A2 P23975 1/20 0.37
▸ HTR2A P28223 1/20 0.37
▸ HTR2C P28335 1/20 0.37
▸ TRPV1 Q8NER1 1/20 0.36
▸ PNMT P11086 1/20 0.36
▸ ASIC3 Q9UHC3 1/20 0.36
▸ SRD5A2 P31213 1/20 0.36
▸ PYGL P06737 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14437215 1.00 SRD5A1 (0.45) SRD5A1CAMK2APGRGFRA3RET
SCHEMBL3202300 1.00 SRD5A1 (0.45) SRD5A1CAMK2APGRGFRA3RET
SCHEMBL227502 1.00 SRD5A1 (0.45) SRD5A1CAMK2APGRGFRA3RET
SCHEMBL31650212 0.89 CAMK2A (0.50) SRD5A1CAMK2APGRKDM1ASLC6A4
SCHEMBL7679993 0.89 CAMK2A (0.50) SRD5A1CAMK2APGRKDM1ASLC6A4
SCHEMBL16794356 0.87 CAMK2A (0.49) SRD5A1CAMK2APGRKDM1ASLC6A4
SCHEMBL9276752 0.84 HTR2A (0.46) SRD5A1CAMK2AKDM1AHTR2AHTR2C
SCHEMBL1576024 0.84 HTR2A (0.46) SRD5A1CAMK2AKDM1AHTR2AHTR2C
SCHEMBL3638981 0.84 HTR2A (0.46) SRD5A1CAMK2AKDM1AHTR2AHTR2C
SCHEMBL27887272 0.78 KDM1A (0.42) SRD5A1CAMK2AKDM1ASLC6A4SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260028348-A1 MODULATORS OF TNF-ALPHA ACTIVITY FORWARD THERAPEUTICS INC (US) 2026-01-29 — — US disclosed
EP-4380932-B1 PROCESS FOR PREPARING AFICAMTEN CYTOKINETICS INC (US) 2025-11-26 — — EP disclosed
US-12247024-B2 Process for preparing aficamten CYTOKINETICS, INC. (US) 2025-03-11 — — US disclosed
US-20250059173-A1 CARDIAC SARCOMERE INHIBITORS CYTOKINETICS, INC. 2025-02-20 — — US disclosed
EP-4491622-A2 CARDIAC SARCOMERE INHIBITORS Cytokinetics, Inc. (US) 2025-01-15 — — EP disclosed
EP-3740481-B9 DIHYDROBENZOFURAN AND INDEN ANALOGS AS CARDIAC SARCOMERE INHIBITORS CYTOKINETICS INC (US) 2024-10-23 — — EP disclosed
US-12065436-B2 Cardiac sarcomere inhibitors CYTOKINETICS, INC. (US) 2024-08-20 — — US disclosed
WO-2024148191-A1 MODULATORS OF TNF-α ACTIVITY FORWARD THERAPEUTICS, INC. (US) 2024-07-11 — — WO disclosed
EP-3740481-B1 DIHYDROBENZOFURAN AND INDEN ANALOGS AS CARDIAC SARCOMERE INHIBITORS CYTOKINETICS INC (US) 2024-06-26 — — EP disclosed
US-20240150336-A1 PROCESS FOR PREPARING AFICAMTEN CYTOKINETICS, INC. 2024-05-09 — — US disclosed
US-20120302566-A1 INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-11-29 — — US disclosed
US-20120302566-A1 INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-11-29 — — US disclosed
US-20120302566-A1 INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-11-29 — — US disclosed
WO-2012101011-A2 NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2012-08-02 — — WO disclosed
WO-2012072691-A1 INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-06-07 — — WO disclosed
WO-2012072691-A1 INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-06-07 — — WO disclosed
WO-2011114271-A1 2,3 DIHYDRO-1H-INDEN-1-YL- 2,7-DIAZASPIRO [3.6] NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR PFIZER INC. (US) 2011-09-22 — — WO disclosed
US-20110230461-A1 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES PFIZER INC. 2011-09-22 — — US disclosed
US-20110230461-A1 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES PFIZER INC. 2011-09-22 — — US disclosed
US-20110230461-A1 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES PFIZER INC. 2011-09-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12065436-B2 Cardiac sarcomere inhibitors TNNI3, TNNT2, MYLK2 SRD5A1 862/4885CAMK2A 407/4885PGR 4568/4885
US-20240150336-A1 PROCESS FOR PREPARING AFICAMTEN INMT, PNMT, NNMT SRD5A1 1244/4885CAMK2A 1381/4885PGR 4451/4885
US-20120302566-A1 INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS GPR119, INSR, GPR52 SRD5A1 496/4885CAMK2A 2062/4885PGR 2077/4885
US-20260028348-A1 MODULATORS OF TNF-ALPHA ACTIVITY TNF, TNFRSF1A, TNFRSF9 SRD5A1 361/4885CAMK2A 3616/4885PGR 696/4885
US-20250059173-A1 CARDIAC SARCOMERE INHIBITORS TNNI3, TNNT2, MYLK2 SRD5A1 862/4885CAMK2A 407/4885PGR 4568/4885
US-20110230461-A1 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES GIPR, GLP1R, GHSR SRD5A1 947/4885CAMK2A 926/4885PGR 643/4885
US-12247024-B2 Process for preparing aficamten INMT, PNMT, NNMT SRD5A1 1272/4885CAMK2A 1397/4885PGR 4468/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.