Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11146525 | 1.00 | ACHE (0.50) | ACHEPKMALDH1A1BCHERAPGEF4 | |
| SCHEMBL760068 | 0.94 | LMNA (0.49) | ACHEPKMALDH1A1BCHERAPGEF4 | |
| Toliodium SCHEMBL2895871 | 0.88 | GAA (0.50) | ACHEPKMALDH1A1RAPGEF4LMNA | |
| SCHEMBL3759299 | 0.87 | ALDH1A1 (0.47) | ACHEALDH1A1BCHELMNAEGFR | |
| SCHEMBL2896059 | 0.85 | ALDH1A1 (0.48) | PKMALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2634849 | 0.85 | ALDH1A1 (0.50) | PKMALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL13401281 | 0.84 | ACHE (0.71) | ACHEALDH1A1KMT2ALMNAMAPT | |
| SCHEMBL7903612 | 0.83 | HSD11B1 (0.48) | ACHEPKMALDH1A1MEN1KMT2A | |
| SCHEMBL31622746 | 0.83 | CYP1A2 (0.47) | ACHEALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL11146478 | 0.81 | HTT (0.62) | ALDH1A1MEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3284736-B1 | FLUORINATION OF AROMATIC RING SYSTEMS | NUTECH VENTURES (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-3284736-A1 | FLUORINATION OF AROMATIC RING SYSTEMS | NUtech Ventures (US) | 2018-02-21 | — | — | EP | disclosed |
| EP-2537826-B1 | Fluorination of aromatic ring systems | NUTECH VENTURES (US) | 2017-03-08 | — | — | EP | disclosed |
| US-9302990-B2 | Fluorination of aromatic ring systems | NUTECH VENTURES (US) | 2016-04-05 | — | — | US | disclosed |
| EP-2726446-A2 | FLUORINATION OF AROMATIC RING SYSTEMS | Nutech Ventures (US) | 2014-05-07 | — | — | EP | disclosed |
| US-8604213-B2 | Fluorination of aromatic ring systems | NUTECH VENTURES (US) | 2013-12-10 | — | — | US | disclosed |
| US-8377704-B2 | Detection and quantification of anions | NUTECH VENTURES (US) | 2013-02-19 | — | — | US | disclosed |
| WO-2013003734-A2 | FLUORINATION OF AROMATIC RING SYSTEMS | NUTECH VENTURES (US) | 2013-01-03 | — | — | WO | disclosed |
| EP-2537826-A1 | Fluorination of aromatic ring systems | Nutech Ventures (US) | 2012-12-26 | — | — | EP | disclosed |
| US-20120004417-A1 | FLUORINATION OF AROMATIC RING SYSTEMS | NATIONAL SCIENCE FOUNDATION | 2012-01-05 | — | — | US | disclosed |
| US-20110313170-A1 | Fluorination of Aromatic Ring Systems | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2011-12-22 | — | — | US | disclosed |
| EP-2349977-A2 | FLUORINATION OF AROMATIC RING SYSTEMS | The Board of Regents of the University of Nebraska (US) | 2011-08-03 | — | — | EP | disclosed |
| US-20110091982-A1 | Detection and Quantification of Anions | NUTECH VENTURES | 2011-04-21 | — | — | US | disclosed |
| US-7759045-B2 | Chemically amplified positive resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-07-20 | — | — | US | disclosed |
| WO-2010048170-A2 | FLUORINATION OF AROMATIC RING SYSTEMS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2010-04-29 | — | — | WO | disclosed |
| US-20090004601-A1 | Chemically amplified positive resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-01-01 | — | — | US | disclosed |
| US-6893794-B2 | Chemical amplification type positive resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-05-17 | — | — | US | disclosed |
| US-20040018445-A1 | Chemical amplification type positive resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-01-29 | — | — | US | disclosed |
| US-20030068573-A1 | Chemical amplification type positive resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004417-A1 | FLUORINATION OF AROMATIC RING SYSTEMS | PFAS, SLC43A1, DDC | ACHE 3064/4885PKM 1026/4885ALDH1A1 2774/4885 |
| US-20110313170-A1 | Fluorination of Aromatic Ring Systems | PFAS, SLC43A1, DDC | ACHE 3064/4885PKM 1026/4885ALDH1A1 2774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.