Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467582 | 0.81 | KDM4E (0.38) | KDM4EALDH1A1MAPTPKMHRH3 | |
| SCHEMBL1385856 | 0.80 | ADRA2C (0.33) | KDM4EALDH1A1MAPTHRH3GAA | |
| SCHEMBL2485210 | 0.75 | KMT2A (0.33) | HRH3GAA | |
| SCHEMBL2477477 | 0.73 | NPSR1 (0.43) | KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL2483016 | 0.72 | GPR119 (0.30) | — | |
| SCHEMBL2480167 | 0.72 | HRH3 (0.36) | ALDH1A1HRH3GAA | |
| SCHEMBL2482791 | 0.71 | CASP1 (0.34) | — | |
| SCHEMBL467489 | 0.67 | PIM1 (0.36) | KDM4EALDH1A1HRH3 | |
| SCHEMBL2481612 | 0.67 | KDM4E (0.40) | KDM4EALDH1A1MAPTPKMHRH3 | |
| SCHEMBL14369698 | 0.64 | KDM4E (0.41) | KDM4EALDH1A1MAPTPKMHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376493-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVE | MSD K.K. (JP) | 2011-10-19 | — | — | EP | disclosed |
| EP-2376494-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVES | MSD K.K. (JP) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010067886-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-06-17 | — | — | WO | disclosed |
| WO-2010067888-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-06-17 | — | — | WO | disclosed |