Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463780 | 0.80 | TSHR (0.39) | KDM1ACYP1A2CYP2D6CYP2C9ALDH1A1 | |
| SCHEMBL27622925 | 0.79 | BRPF1 (0.43) | KEAP1PGRNR3C2ATMHSD17B1 | |
| SCHEMBL5778734 | 0.78 | AURKA (0.45) | ALDH1A1HTTAURKAKDRAURKB | |
| SCHEMBL16320747 | 0.77 | PTGS2 (0.42) | PTGS2ATMLMNA | |
| SCHEMBL3331314 | 0.73 | KLK7 (0.49) | KDM1ACYP1A2ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL29625693 | 0.73 | CA1 (0.67) | KEAP1PGRNR3C2ATMALDH1A1 | |
| SCHEMBL30186176 | 0.73 | CA1 (0.67) | KEAP1PGRNR3C2ATMALDH1A1 | |
| SCHEMBL171701 | 0.73 | CA1 (0.67) | KEAP1PGRNR3C2ATMALDH1A1 | |
| SCHEMBL1767004 | 0.70 | TSHR (0.43) | CYP1A2CYP2D6CYP2C9CASP7ALDH1A1 | |
| SCHEMBL8388156 | 0.70 | LMNA (0.53) | CA1CA2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339663-B1 | NAPHTHALENE DERIVATIVES | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | claimed |
| US-20160229774-A1 | PROCESSES FOR MAKING CYCLOHEXANE COMPOUNDS | EASTMAN CHEMICAL COMPANY (US) | 2016-08-11 | — | — | US | disclosed |
| US-20160229784-A1 | PROCESSES FOR MAKING CYCLOHEXANE COMPOUNDS | EASTMAN CHEMICAL COMPANY (US) | 2016-08-11 | — | — | US | disclosed |
| US-9346737-B2 | Processes for making cyclohexane compounds | EASTMAN CHEMICAL COMPANY (US) | 2016-05-24 | — | — | US | disclosed |
| US-9340482-B2 | Processes for making cyclohexane compounds | EASTMAN CHEMICAL COMPANY (US) | 2016-05-17 | — | — | US | disclosed |
| US-9328050-B1 | Processes for making hydroxymethylbenzoic acid compounds | EASTMAN CHEMICAL COMPANY (US) | 2016-05-03 | — | — | US | disclosed |
| CN-103153463-B | The method of recovery and recycle of ruthenium homogeneous catalyst | EASTMAN CHEMICAL CO. (US) | 2015-09-09 | — | — | CN | disclosed |
| WO-2015102893-A1 | PROCESS FOR THE PREPARATION OF CYCLOHEXANE CARBOXYLIC ACID COMPOUNDS | EASTMAN CHEMICAL COMPANY (US) | 2015-07-09 | — | — | WO | disclosed |
| WO-2015102892-A1 | PROCESS FOR THE PREPARATION OF AT LEAST ONE HYDROXYMETHYLCYCLOHEXANE | EASTMAN CHEMICAL COMPANY (US) | 2015-07-09 | — | — | WO | disclosed |
| US-20150183699-A1 | PROCESSES FOR MAKING CYCLOHEXANE COMPOUNDS | EASTMAN CHEMICAL COMPANY (US) | 2015-07-02 | — | — | US | disclosed |
| EP-1585714-A2 | PROCESSES FOR THE PREPARATION OF HIGHER MOLECULAR WEIGHT KETONES | EASTMAN CHEMICAL COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2005058292-A1 | NEW USE IN GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2005-06-30 | — | — | WO | disclosed |
| WO-2005028406-A2 | PROCESSES FOR THE PREPARATION OF HIGHER MOLECULAR WEIGHT KETONES | EASTMAN CHEMICAL COMPANY (US) | 2005-03-31 | — | — | WO | disclosed |
| WO-2005005361-A1 | PROCESSES FOR PREPARING BETA-HYDROXY-KETONES AND ALPHA, BETA-UNSATURATED KETONES | EASTMAN CHEMICAL COMPANY (US) | 2005-01-20 | — | — | WO | disclosed |
| US-20050004401-A1 | Processes for preparing beta-hydroxy-ketones and alpha,beta-unsaturated ketones | EASTMAN CHEMICAL COMPANY | 2005-01-06 | — | — | US | disclosed |
| US-20040122261-A1 | Processes for the preparation of higher molecular weight ketones | MCCUSKER-ORTH JENNIFER ELLEN (US) | 2004-06-24 | — | — | US | disclosed |
| US-20040053890-A1 | Naphthalene derivatives | NOVARTIS AG (CH) | 2004-03-18 | — | — | US | disclosed |
| US-20040044229-A1 | Process for alpha,beta-dihydroxyalkenes and derivatives | HEMBRE ROBERT THOMAS (US) | 2004-03-04 | — | — | US | disclosed |
| EP-1339663-A2 | NAPHTHALENE DERIVATIVES | Novartis AG (CH) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002042248-A2 | NAPHTHALENE DERIVATIVES | NOVARTIS AG (CH) | 2002-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044229-A1 | Process for alpha,beta-dihydroxyalkenes and derivatives | CYP8B1, EBP, DEGS1 | KEAP1 1859/4885KDM1A 2284/4885PTGS2 1071/4885 |
| US-20160229774-A1 | PROCESSES FOR MAKING CYCLOHEXANE COMPOUNDS | DHPS, HPD, HAAO | KEAP1 1153/4885KDM1A 605/4885PTGS2 364/4885 |
| US-20040053890-A1 | Naphthalene derivatives | CYP1A1, SULT1E1, CYP2F1 | KEAP1 687/4885KDM1A 3021/4885PTGS2 803/4885 |
| US-20050004401-A1 | Processes for preparing beta-hydroxy-ketones and alpha,beta-unsaturated ketones | EBP, CYP8B1, BCKDK | KEAP1 251/4885KDM1A 1542/4885PTGS2 1082/4885 |
| US-20150183699-A1 | PROCESSES FOR MAKING CYCLOHEXANE COMPOUNDS | DHPS, HPD, HAAO | KEAP1 1153/4885KDM1A 605/4885PTGS2 364/4885 |
| US-20040122261-A1 | Processes for the preparation of higher molecular weight ketones | AKR1D1, ADH1C, AKR1C2 | KEAP1 314/4885KDM1A 1947/4885PTGS2 1330/4885 |
| US-20160229784-A1 | PROCESSES FOR MAKING CYCLOHEXANE COMPOUNDS | DHPS, HPD, HAAO | KEAP1 1153/4885KDM1A 605/4885PTGS2 364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.