SCHEMBL250424

SCHEMBL250424

C=CC(=O)C(C)C(N)S(=O)(=O)O

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27866798 0.78 TSHR (0.33) TSHR
SCHEMBL4307611 0.78 TSHR (0.36) TSHR
Acrylic Acid SCHEMBL27603081 0.75 LMNA (0.42) TSHR
Acrylamide SCHEMBL27553594 0.75 TSHR (0.46) TSHR
SCHEMBL28265932 0.75
Acrylamide SCHEMBL27946770 0.73 TSHR (0.44) TSHR
SCHEMBL28361534 0.73 SLC7A5 (0.40)
Propene SCHEMBL27938034 0.71 TP53 (0.30)
SCHEMBL27681789 0.71 TDP1 (0.33)
SCHEMBL6856744 0.70 TSHR (0.33) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2315615-B1 METHODS AND KITS FOR PERMANENTLY COLORING HAIR USING PERSULFATES, PERBORATES OR PERCARBONATES OREAL (FR) 2019-11-20 EP disclosed
EP-2225003-B1 METHODS AND KITS FOR PERMANENTLY COLORING HAIR USING PERSULFATES, PERBORATES OR PERCARBONATES L'ORÉAL (FR) 2017-10-11 EP disclosed
US-9578944-B2 Compositions and methods for altering the appearance of hair L'OREAL (FR) 2017-02-28 US disclosed
US-9565915-B2 Compositions and methods for altering the appearance of hair L'OREAL (FR) 2017-02-14 US disclosed
US-9566221-B2 Methods for altering the color and appearance of hair L'OREAL (FR) 2017-02-14 US disclosed
US-9565916-B2 Compositions and methods for altering the appearance of hair L'OREAL (FR) 2017-02-14 US disclosed
US-9474700-B2 Methods for altering the color and appearance of hair L'OREAL (FR) 2016-10-25 US disclosed
EP-2315573-B2 METHODS AND KITS FOR PERMANENTLY COLORING HAIR USING A DEVELOPER COMPOSITION CONTAINING AN OXIDIZER COMPOSITION AND A SHAMPOO ORÉAL L (FR) 2016-07-27 EP disclosed
US-20150290093-A1 METHODS FOR ALTERING THE COLOR AND APPEARANCE OF HAIR L'OREAL (FR) 2015-10-15 US disclosed
US-20150265513-A1 METHODS FOR ALTERING THE COLOR AND APPEARANCE OF HAIR L'OREAL (FR) 2015-09-24 US disclosed
US-20130042883-A1 COMPOSITIONS AND METHODS FOR LIGHTENING THE COLOR OF RELAXED OR STRAIGHTENED HAIR L'OREAL (FR) 2013-02-21 US disclosed
US-8163037-B2 Methods and kits for providing lift and then a permanent color to hair L'OREAL (FR) 2012-04-24 US disclosed
US-8088176-B2 Methods and kits for permanently coloring hair using a developer composition containing an oxidizer composition and a shampoo L'OREAL (FR) 2012-01-03 US disclosed
US-20110209720-A1 METHODS AND KITS FOR PERMANENTLY COLORING HAIR USING A DEVELOPER COMPOSITION CONTAINING AN OXIDIZER COMPOSITION AND A SHAMPOO L'OREAL (FR) 2011-09-01 US disclosed
US-20110203605-A1 METHODS AND KITS FOR PROVIDING LIFT AND THEN A PERMANENT COLOR TO HAIR L'OREAL (FR) 2011-08-25 US disclosed
US-7905926-B2 Methods and kits for permanently coloring hair L'ORÉAL (FR) 2011-03-15 US disclosed
US-20100192969-A1 METHODS AND KITS FOR PERMANENTLY COLORING HAIR L'OREAL (FR) 2010-08-05 US disclosed
US-20050129644-A1 Use of hydroxycarboxylic acids and salts thereof as complexing agents in reducing compositions for bleaching or permanently reshaping keratin fibres L'OREAL S.A. (FR) 2005-06-16 US disclosed
US-20050036970-A1 Reducing compositions for bleaching or permanently reshaping keratin fibres comprising polycarboxylic acids and salts thereof as complexing agents L'OREAL S.A. (FR) 2005-02-17 US disclosed
US-20050011017-A1 Oxidizing composition comprising hydroxycarboxylic acids and salts thereof as complexing agents for dyeing, bleaching or permanently reshaping keratin fibres L'OREAL S.A. (FR) 2005-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050129644-A1 Use of hydroxycarboxylic acids and salts thereof as complexing agents in reducing compositions for bleaching or permanently reshaping keratin fibres RARA, RARB, RARG TSHR 3364/4885
US-20110203605-A1 METHODS AND KITS FOR PROVIDING LIFT AND THEN A PERMANENT COLOR TO HAIR ALDH1A3, COXFA4L2, LDHB TSHR 3132/4885
US-20110209720-A1 METHODS AND KITS FOR PERMANENTLY COLORING HAIR USING A DEVELOPER COMPOSITION CONTAINING AN OXIDIZER COMPOSITION AND A SHAMPOO PPOX, SCO2, SDHB TSHR 3786/4885
US-20150290093-A1 METHODS FOR ALTERING THE COLOR AND APPEARANCE OF HAIR TYR, COXFA4L2, MT-CO3 TSHR 4453/4885
US-20050011017-A1 Oxidizing composition comprising hydroxycarboxylic acids and salts thereof as complexing agents for dyeing, bleaching or permanently reshaping keratin fibres HAO2, KRT18, RARA TSHR 4205/4885
US-20150265513-A1 METHODS FOR ALTERING THE COLOR AND APPEARANCE OF HAIR COXFA4L2, TYR, COX5A TSHR 4564/4885
US-20100192969-A1 METHODS AND KITS FOR PERMANENTLY COLORING HAIR CYB5R3, COXFA4L2, PPOX TSHR 3847/4885
US-20050036970-A1 Reducing compositions for bleaching or permanently reshaping keratin fibres comprising polycarboxylic acids and salts thereof as complexing agents RARA, RARB, KRT18 TSHR 3513/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.