Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16654312 | 0.85 | HPGD (0.52) | TTRHPGDHSD17B10CYP3A4CRHBP | |
| SCHEMBL23216410 | 0.83 | TTR (0.41) | TTRHPGDHSD17B10CYP3A4CRHBP | |
| SCHEMBL20286649 | 0.80 | HSD17B10 (0.52) | TTRHPGDHSD17B10CYP3A4ALDH1A1 | |
| SCHEMBL14957896 | 0.78 | TTR (0.45) | TTRHSD17B10ENPP2CYP1A2ALOX15 | |
| SCHEMBL21305034 | 0.78 | TTR (0.45) | TTRENPP2ACHECYP2C19SMN1; SMN2 | |
| SCHEMBL29951302 | 0.78 | NOTUM (0.39) | TTRHPGDHSD17B10CYP3A4CRHBP | |
| SCHEMBL31522467 | 0.74 | TTR (0.47) | TTRHPGDHSD17B10CYP3A4ENPP2 | |
| SCHEMBL806837 | 0.73 | ENPP2 (0.47) | ALDH1A1ENPP2TSHRCA4CA6 | |
| SCHEMBL29209517 | 0.73 | ENPP2 (0.52) | TTRHSD17B10CYP3A4ALDH1A1ENPP2 | |
| SCHEMBL177673 | 0.73 | ENPP2 (0.52) | TTRHSD17B10CYP3A4ALDH1A1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240391926-A1 | SPIROINDOLINONE COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D.E. SHAW RESEARCH, LLC | 2024-11-28 | — | — | US | disclosed |
| EP-4351569-A2 | SPIROINDOLINONE COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D.E. Shaw Research, LLC (US) | 2024-04-17 | — | — | EP | disclosed |
| CN-117597120-A | Spiroindolone compounds as Kv1.3 potassium Shaker channel blockers | D·E·萧尔研究有限责任公司 | 2024-02-23 | — | — | CN | disclosed |
| WO-2023079988-A1 | FLAME-RETARDANT NON-AQUEOUS ELECTROLYTIC SOLUTION AND SECONDARY BATTERY USING SAME | 国立大学法人京都大学 | 2023-05-11 | — | — | WO | disclosed |
| CN-115850021-A | Preparation method of polychlorinated biphenyl standard substance | 上海安谱实验科技股份有限公司 | 2023-03-28 | — | — | CN | disclosed |
| US-20230023559-A1 | ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D. E. SHAW RESEARCH, LLC (US) | 2023-01-26 | — | — | US | disclosed |
| US-20230026611-A1 | ARYL HETEROCYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D. E. SHAW RESEARCH, LLC | 2023-01-26 | — | — | US | disclosed |
| US-20230026611-A1 | ARYL HETEROCYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D. E. SHAW RESEARCH, LLC | 2023-01-26 | — | — | US | disclosed |
| US-20230023559-A1 | ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D. E. SHAW RESEARCH, LLC (US) | 2023-01-26 | — | — | US | disclosed |
| WO-2022251561-A2 | SPIROINDOLINONE COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D.E. SHAW RESEARCH, LLC (US) | 2022-12-01 | — | — | WO | disclosed |
| WO-2013078071-A1 | ISOXAZOLINE DERIVATIVES USED IN THE CONTROL OF ECTOPARASITES | ELI LILLY AND COMPANY (US) | 2013-05-30 | — | — | WO | disclosed |
| US-20130131017-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130131016-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130131017-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130131017-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2013-05-23 | — | — | US | disclosed |
| EP-2556060-A1 | SUBSTITUTED 3,5- DIPHENYL-ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES | AH USA 42 LLC (US) | 2013-02-13 | — | — | EP | disclosed |
| WO-2012168162-A1 | BENZOCYCLOHEPTENE ACETIC ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-12-13 | — | — | WO | disclosed |
| US-20120309796-A1 | BENZOCYCLOHEPTENE ACETIC ACIDS | FIROOZNIA FARIBORZ (US) | 2012-12-06 | — | — | US | disclosed |
| WO-2011124998-A1 | SUBSTITUTED 3,5- DI PHENYL - ISOXAZOLINE DERIVATIVES AS INSECTICIDES AND ACARICIDES | PFIZER INC. (US) | 2011-10-13 | — | — | WO | disclosed |
| US-20110251247-A1 | SUBSTITUTED ISOXAZOLINE DERIVATIVES | PFIZER INC. (US) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240391926-A1 | SPIROINDOLINONE COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | KCNK3, KCNJ2, KCND3 | TTR 2691/4885HPGD 2562/4885HSD17B10 951/4885 |
| US-20130131016-A1 | BORON-CONTAINING SMALL MOLECULES | BCL6B, SLC7A5, BCL6 | TTR 2691/4885HPGD 4367/4885HSD17B10 2834/4885 |
| US-20130131017-A1 | BORON-CONTAINING SMALL MOLECULES | BCL6B, BCL6, RB1 | TTR 2936/4885HPGD 4436/4885HSD17B10 2443/4885 |
| US-20230026611-A1 | ARYL HETEROCYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | KCNA3, KCNH2, KCNJ2 | TTR 2629/4885HPGD 2935/4885HSD17B10 1230/4885 |
| US-20110251247-A1 | SUBSTITUTED ISOXAZOLINE DERIVATIVES | CYP4X1, COL1A1, RDX | TTR 2714/4885HPGD 4187/4885HSD17B10 1932/4885 |
| US-20230023559-A1 | ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | KCNJ2, KCNA3, KCNH3 | TTR 2853/4885HPGD 2590/4885HSD17B10 715/4885 |
| US-20120309796-A1 | BENZOCYCLOHEPTENE ACETIC ACIDS | ACAT2, ACAT1, CYP27A1 | TTR 2438/4885HPGD 88/4885HSD17B10 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.