Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.65 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.65 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 9/20 | 0.42 |
| ▸ | FNTA | P49354 | 2/20 | 0.37 |
| ▸ | FNTB | P49356 | 2/20 | 0.37 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2534816 | 1.00 | PTGS1 (0.65) | PTGS1GSTK1GLO1NOD1FNTA | |
| Bromide SCHEMBL4250677 | 0.99 | PTGS1 (0.64) | PTGS1GSTK1GLO1NOD1FNTA | |
| SCHEMBL1503471 | 0.89 | PTGS1 (0.68) | PTGS1GSTK1GLO1NOD1FNTA | |
| SCHEMBL10490007 | 0.89 | PTGS1 (0.68) | PTGS1GSTK1GLO1NOD1FNTA | |
| SCHEMBL6257074 | 0.89 | PTGS1 (0.71) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione Ethyl Ester SCHEMBL680361 | 0.86 | PTGS1 (0.71) | PTGS1GSTK1GLO1NOD1 | |
| Glutathione Ethyl Ester SCHEMBL9817298 | 0.86 | PTGS1 (0.71) | PTGS1GSTK1GLO1NOD1 | |
| Glutathione Ethyl Ester SCHEMBL7530345 | 0.86 | PTGS1 (0.71) | PTGS1GSTK1GLO1NOD1 | |
| SCHEMBL2532429 | 0.86 | PTGS1 (0.53) | PTGS1GSTK1GLO1NOD1FNTA | |
| SCHEMBL12252220 | 0.86 | PTGS1 (0.64) | PTGS1GSTK1GLO1NOD1FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170189429-A1 | Treating Arrhythmia with Mitochondrial-Targeted Antioxidants | RHODE ISLAND HOSPITAL | 2017-07-06 | — | — | US | claimed |
| EP-3166600-A1 | TREATING ARRHYTHMIA WITH MITOCHONDRIAL-TARGETED ANTIOXIDANTS | Rhode Island Hospital (US) | 2017-05-17 | — | — | EP | claimed |
| WO-2016007921-A1 | TREATING ARRHYTHMIA WITH MITOCHONDRIAL-TARGETED ANTIOXIDANTS | RHODEL ISLAND HOSPITAL (US) | 2016-01-14 | — | — | WO | claimed |
| WO-2017214297-A1 | COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME | OREGON STATE UNIVERSITY (US) | 2017-12-14 | — | — | WO | disclosed |
| US-20170189429-A1 | Treating Arrhythmia with Mitochondrial-Targeted Antioxidants | RHODE ISLAND HOSPITAL | 2017-07-06 | — | — | US | disclosed |
| EP-3166600-A1 | TREATING ARRHYTHMIA WITH MITOCHONDRIAL-TARGETED ANTIOXIDANTS | Rhode Island Hospital (US) | 2017-05-17 | — | — | EP | disclosed |
| WO-2016007921-A1 | TREATING ARRHYTHMIA WITH MITOCHONDRIAL-TARGETED ANTIOXIDANTS | RHODEL ISLAND HOSPITAL (US) | 2016-01-14 | — | — | WO | disclosed |
| US-8470861-B2 | Mitochondria-targeted antioxidant prodrugs and methods of use | UNIVERSITY OF ROCHESTER (US) | 2013-06-25 | — | — | US | disclosed |
| US-20110257107-A1 | Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochondria | UNIVERSITY OF ROCHESTER (US) | 2011-10-20 | — | — | US | disclosed |
| US-20100168198-A1 | Mitochondria-targeted antioxidant prodrugs and methods of use | UNIVERSITY OF ROCHESTER | 2010-07-01 | — | — | US | disclosed |
| US-20090306125-A1 | Mitochondria-Targeted Antioxidant Prodrugs and Methods of Use | UNIVERSITY OF ROCHESTER | 2009-12-10 | — | — | US | disclosed |
| EP-1968650-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | University of Rochester (US) | 2008-09-17 | — | — | EP | disclosed |
| EP-1954322-A2 | MITOCHONDRIA-TARGETED ANTIOXIDANT PRODRUGS AND METHODS OF USE | University of Rochester (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007076323-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | UNIVERSITY OF ROCHESTER (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007062343-A2 | MITOCHONDRIA-TARGETED ANTIOXIDANT PRODRUGS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2007-05-31 | — | — | WO | disclosed |
| US-20070099845-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | ROCHESTER, UNIVERSITY OF | 2007-05-03 | — | — | US | disclosed |
| EP-1691818-A4 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | UNIV ROCHESTER (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1691818-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | University of Rochester (US) | 2006-08-23 | — | — | EP | disclosed |
| US-20060160748-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | ROCHESTER, UNIVERSITY OF | 2006-07-20 | — | — | US | disclosed |
| WO-2005051978-A2 | COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF | UNIVERSITY OF ROCHESTER (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170189429-A1 | Treating Arrhythmia with Mitochondrial-Targeted Antioxidants | COQ8A, SQOR, COQ8B | PTGS1 1039/4885GSTK1 270/4885GLO1 642/4885 |
| US-20090306125-A1 | Mitochondria-Targeted Antioxidant Prodrugs and Methods of Use | TXNRD2, HADHA, PRDX5 | PTGS1 541/4885GSTK1 227/4885GLO1 319/4885 |
| US-20110257107-A1 | Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochondria | TXN2, TXNRD2, AIFM1 | PTGS1 681/4885GSTK1 187/4885GLO1 738/4885 |
| US-20100168198-A1 | Mitochondria-targeted antioxidant prodrugs and methods of use | TXNRD2, HADHA, PRDX5 | PTGS1 541/4885GSTK1 227/4885GLO1 319/4885 |
| US-20070099845-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | TXN2, GLS, PDF | PTGS1 640/4885GSTK1 227/4885GLO1 551/4885 |
| US-20060160748-A1 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof | TXN2, TXNRD2, HSPA9 | PTGS1 667/4885GSTK1 217/4885GLO1 576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.