Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.50 |
| ▸ | CA12 known ✓ | O43570 | 4/20 | 0.47 |
| ▸ | CA1 known ✓ | P00915 | 4/20 | 0.47 |
| ▸ | CA2 known ✓ | P00918 | 4/20 | 0.47 |
| ▸ | CA7 | P43166 | 4/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL10693578 | 0.96 | THRB (0.50) | THRBCA12CA1CA2CA7 | |
| SCHEMBL11079476 | 0.87 | TDP1 (0.47) | CA1CA2CA7CA9ALDH1A1 | |
| SCHEMBL23495983 | 0.84 | CA2 (0.56) | THRBCA12CA1CA2CA7 | |
| SCHEMBL6914099 | 0.82 | TDP1 (0.47) | THRBCA1CA2CA7CA9 | |
| SCHEMBL6915047 | 0.82 | TDP1 (0.47) | THRBCA1CA2CA7CA9 | |
| SCHEMBL6918159 | 0.82 | TDP1 (0.47) | THRBCA1CA2CA7CA9 | |
| SCHEMBL6909097 | 0.82 | TDP1 (0.52) | CA1CA2CA7CA9ALDH1A1 | |
| Potassium Ion SCHEMBL11466345 | 0.82 | TDP1 (0.47) | THRBCA1CA2CA7CA9 | |
| SCHEMBL6915052 | 0.82 | TDP1 (0.47) | THRBCA1CA2CA7CA9 | |
| Silver SCHEMBL31112849 | 0.82 | TDP1 (0.47) | THRBCA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230251277-A1 | METHOD FOR DETERMINING THE LEVEL OF VITAMIN D AND METABOLITES THEREOF | ROCHE DIAGNOSTICS OPERATIONS, INC. | 2023-08-10 | — | — | US | disclosed |
| EP-4222502-A1 | A METHOD FOR DETERMINING THE LEVEL OF VITAMIN D AND METABOLITES THEREOF | F. Hoffmann-La Roche AG (CH) | 2023-08-09 | — | — | EP | disclosed |
| CN-116209901-A | Method for determining the amount of vitamin D and its metabolites | 豪夫迈·罗氏有限公司 | 2023-06-02 | — | — | CN | disclosed |
| WO-2022069392-A1 | A METHOD FOR DETERMINING THE LEVEL OF VITAMIN D AND METABOLITES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2022-04-07 | — | — | WO | disclosed |