Sugi Predict

Sugi Predict / Compounds / SCHEMBL2537809

SCHEMBL2537809

SCHEMBL2537809

O=Cc1cccc(Oc2cncnc2)c1

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 1/20 0.47
▸ LMNA P02545 2/20 0.46
▸ TDP1 Q9NUW8 2/20 0.46
▸ MAOA P21397 7/20 0.45
▸ MAOB P27338 7/20 0.45
▸ ALDH1A1 P00352 3/20 0.43
▸ MAPT P10636 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ NPC1 O15118 3/20 0.41
▸ RAB9A P51151 3/20 0.41
▸ POLB P06746 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ TLR4 O00206 1/20 0.40
▸ TLR2 O60603 1/20 0.40
▸ GAA P10253 1/20 0.38
▸ HPGD P15428 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30302069 1.00 SRC (0.47) SRCLMNATDP1MAOAMAOB
SCHEMBL6849018 0.85 SRC (0.60) SRCLMNATDP1MAOAMAOB
SCHEMBL30631693 0.85 SRC (0.60) SRCLMNATDP1MAOAMAOB
SCHEMBL30218733 0.85 LMNA (0.68) SRCLMNATDP1MAOAMAOB
SCHEMBL2531633 0.85 LMNA (0.68) SRCLMNATDP1MAOAMAOB
SCHEMBL6852137 0.83 SRC (0.58) SRCLMNATDP1MAOAMAOB
Benzene SCHEMBL17267850 0.81 MAOA (0.58) SRCLMNATDP1MAOAMAOB
SCHEMBL6856729 0.81 SRC (0.56) SRCLMNATDP1MAOAMAOB
SCHEMBL29195023 0.81 TERT (0.45) SRCLMNATDP1MAOAMAOB
SCHEMBL30715053 0.81 TERT (0.45) SRCLMNATDP1MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250262205-A1 DUAL MAGL AND FAAH INHIBITORS LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) 2025-08-21 — — US disclosed
US-12318383-B2 Dual MAGL and FAAH inhibitors LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) 2025-06-03 — — US disclosed
US-12258340-B2 Pyrazole MAGL inhibitors H. LUNDBECK A/S (DK) 2025-03-25 — — US disclosed
EP-4424683-A2 DUAL MAGL AND FAAH INHIBITORS Lundbeck La Jolla Research Center, Inc. (US) 2024-09-04 — — EP disclosed
EP-3595665-B1 DUAL MAGL AND FAAH INHIBITORS LUNDBECK LA JOLLA RESEARCH CENTER INC (US) 2024-08-28 — — EP disclosed
CN-118271288-A Dual MAGL and FAAH inhibitors 灵北拉荷亚研究中心公司 2024-07-02 — — CN disclosed
CN-117736178-A Dual MAGL and FAAH inhibitors 灵北拉荷亚研究中心公司 2024-03-22 — — CN disclosed
EP-4335848-A2 DUAL MAGL AND FAAH INHIBITORS Lundbeck La Jolla Research Center, Inc. (US) 2024-03-13 — — EP disclosed
CN-117510468-A Dual MAGL and FAAH inhibitors 灵北拉荷亚研究中心公司 2024-02-06 — — CN disclosed
CN-117466868-A Dual MAGL and FAAH inhibitors 灵北拉荷亚研究中心公司 2024-01-30 — — CN disclosed
EP-1859798-B1 N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR LILLY CO ELI (US) 2015-12-30 — — EP disclosed
US-8044090-B2 N-(2-arylethyl)benzylamines as antagonists of the 5-HT6 receptor ELI LILLY (US) 2011-10-25 — — US disclosed
US-20090306110-A1 N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR CHEN ZHAOGEN 2009-12-10 — — US disclosed
EP-1859798-A1 N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2007-11-28 — — EP disclosed
EP-1379239-B1 N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR LILLY CO ELI (US) 2007-09-12 — — EP disclosed
US-20070099909-A1 N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR CHEN ZHAOGEN 2007-05-03 — — US disclosed
US-7157488-B2 N-(2-Arylethyl) benzylamines as antagonists of the 5-HT6 receptor ELI LILLY AND COMPANY (US) 2007-01-02 — — US disclosed
US-20060009511-A9 N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor CHEN ZHAOGEN 2006-01-12 — — US disclosed
EP-1379239-A2 N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2004-01-14 — — EP disclosed
WO-2002078693-A2 N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2002-10-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12258340-B2 Pyrazole MAGL inhibitors MGLL, PNLIP, LPL SRC 2976/4885LMNA 3058/4885TDP1 1754/4885
US-20060009511-A9 N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor HTR6, HTR2C, HTR1B SRC 3981/4885LMNA 4040/4885TDP1 4272/4885
US-20090306110-A1 N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR HTR6, HTR2C, HTR1B SRC 3981/4885LMNA 4040/4885TDP1 4272/4885
US-20250262205-A1 DUAL MAGL AND FAAH INHIBITORS FAAH, FAAH2, MAG SRC 4409/4885LMNA 3319/4885TDP1 3538/4885
US-12318383-B2 Dual MAGL and FAAH inhibitors FAAH, FAAH2, MAG SRC 4409/4885LMNA 3319/4885TDP1 3538/4885
US-20070099909-A1 N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR HTR6, HTR2C, HTR1B SRC 3981/4885LMNA 4040/4885TDP1 4272/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.