SCHEMBL2544154

SCHEMBL2544154

CCOc1ccc(CCC=O)c(F)c1F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 2/20 0.45
CTSK P43235 2/20 0.45
CTSL P07711 1/20 0.45
TUBB1 Q9H4B7 1/20 0.35
ALDH1A1 P00352 3/20 0.35
L3MBTL1 Q9Y468 3/20 0.34
MAPT P10636 2/20 0.34
NPSR1 Q6W5P4 1/20 0.34
MAPK1 P28482 1/20 0.34
FFAR4 Q5NUL3 2/20 0.34
LMNA P02545 1/20 0.33
ATM Q13315 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
PDE4A P27815 1/20 0.32
PDE4B Q07343 1/20 0.32
PDE4C Q08493 1/20 0.32
PDE4D Q08499 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27828875 0.85 CTSS (0.40) CTSSCTSKCTSLTUBB1ALDH1A1
SCHEMBL11894580 0.83 CTSS (0.40) CTSSCTSKCTSLTUBB1ALDH1A1
SCHEMBL29989116 0.83 CTSS (0.40) CTSSCTSKCTSLTUBB1ALDH1A1
SCHEMBL19240522 0.80 CTSL (0.47) CTSSCTSKCTSLTUBB1ALDH1A1
SCHEMBL10383011 0.80 L3MBTL1 (0.46) ALDH1A1L3MBTL1MAPTNPSR1MAPK1
SCHEMBL9979091 0.78 CTSS (0.49) CTSSCTSKCTSLTUBB1ALDH1A1
SCHEMBL7766136 0.77 L3MBTL1 (0.36) CTSSCTSKCTSLTUBB1ALDH1A1
SCHEMBL28379504 0.77 L3MBTL1 (0.36) CTSSCTSKCTSLTUBB1ALDH1A1
SCHEMBL28374086 0.77 FFAR4 (0.38) CTSSCTSKCTSLALDH1A1L3MBTL1
SCHEMBL12238352 0.77 TYR (0.42) CTSSCTSKCTSLALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9394272-B2 1,3-dioxane compound having fluorine atom in axial position, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2016-07-19 US disclosed
US-20160040067-A1 LIQUID CRYSTAL COMPOUND HAVING BUTENE-BONDING GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2016-02-11 US disclosed
US-20150368225-A1 1,3-DIOXANE COMPOUND HAVING FLUORINE ATOM IN AXIAL POSITION, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2015-12-24 US disclosed
US-8580146-B2 Liquid crystal compound, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2013-11-12 US disclosed
US-8580146-B2 Liquid crystal compound, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2013-11-12 US disclosed
US-8398887-B2 Liquid crystal compounds of butylenes YANTAI VALIANT FINE CHEMICALS CO., LTD. (CN) 2013-03-19 US disclosed
US-8398887-B2 Liquid crystal compounds of butylenes YANTAI VALIANT FINE CHEMICALS CO., LTD. (CN) 2013-03-19 US disclosed
US-20120193577-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2012-08-02 US disclosed
US-20120193577-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2012-08-02 US disclosed
US-20110260106-A1 LIQUID CRYSTAL COMPOUNDS OF BUTYLENES VALIANT CORPORATION LIMITED (CN) 2011-10-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160040067-A1 LIQUID CRYSTAL COMPOUND HAVING BUTENE-BONDING GROUP, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE CXCR1, PIEZO1, L1CAM CTSS 3629/4885CTSK 3185/4885CTSL 3244/4885
US-20120193577-A1 LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE KIF23, MARK3, CCND3 CTSS 2841/4885CTSK 1918/4885CTSL 4048/4885
US-20110260106-A1 LIQUID CRYSTAL COMPOUNDS OF BUTYLENES OR10J3, CNOT1, MYB CTSS 4348/4885CTSK 3060/4885CTSL 4807/4885
US-20150368225-A1 1,3-DIOXANE COMPOUND HAVING FLUORINE ATOM IN AXIAL POSITION, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE CXCR1, HAX1, RCC1 CTSS 3478/4885CTSK 3238/4885CTSL 3775/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.