Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.70 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.60 |
| ▸ | MPO | P05164 | 2/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | BCL2 | P10415 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9776607 | 0.89 | KEAP1 (0.86) | KEAP1HSPA5ALOX5BCL2BCL2L1 | |
| SCHEMBL30616875 | 0.89 | KEAP1 (0.86) | KEAP1HSPA5ALOX5BCL2BCL2L1 | |
| SCHEMBL5188628 | 0.84 | HTR2A (0.46) | KEAP1MPOHSP90AA1HSP90B1TAAR1 | |
| SCHEMBL29506902 | 0.83 | KEAP1 (1.00) | KEAP1HSPA5ALOX5BCL2BCL2L1 | |
| SCHEMBL8925742 | 0.83 | KEAP1 (0.76) | KEAP1HSPA5ALOX5BCL2BCL2L1 | |
| SCHEMBL68653 | 0.83 | KEAP1 (1.00) | KEAP1HSPA5ALOX5BCL2BCL2L1 | |
| SCHEMBL30335116 | 0.82 | KEAP1 (0.75) | KEAP1HSPA5MPOALOX5BCL2 | |
| SCHEMBL87816 | 0.82 | KEAP1 (0.75) | KEAP1HSPA5MPOALOX5BCL2 | |
| SCHEMBL7470790 | 0.82 | MPO (0.65) | KEAP1HSPA5MPOTAAR1 | |
| SCHEMBL920838 | 0.81 | KEAP1 (0.96) | KEAP1HSPA5ALOX5BCL2BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12590072-B2 | Thyromimetics | AUTOBAHN THERAPEUTICS, INC. (US) | 2026-03-31 | — | — | US | disclosed |
| EP-4662219-A2 | PRODRUGS OF THYROID HORMONE ANALOGS, METHODS OF MAKING AND METHODS OF USING THEREOF | ASCLETIS PHARMA (CHINA) CO., LIMITED (HK) | 2025-12-17 | — | — | EP | disclosed |
| US-20240294561-A1 | Prodrugs of Thyroid Hormone Analogs, Methods of Making and Methods of Using Thereof | ASCLETIS PHARMA (CHINA) CO., LIMITED (CN) | 2024-09-05 | — | — | US | disclosed |
| WO-2024167961-A2 | PRODRUGS OF THYROID HORMONE ANALOGS, METHODS OF MAKING AND METHODS OF USING THEREOF | GANNEX, LLC (US) | 2024-08-15 | — | — | WO | disclosed |
| US-20230242492-A1 | THYROMIMETICS | AUTOBAHN THERAPEUTICS, INC. | 2023-08-03 | — | — | US | disclosed |
| US-20230242492-A1 | THYROMIMETICS | AUTOBAHN THERAPEUTICS, INC. | 2023-08-03 | — | — | US | disclosed |
| US-11667606-B2 | Thyromimetics | AUTOBAHN THERAPEUTICS, INC. (US) | 2023-06-06 | — | — | US | disclosed |
| US-11667606-B2 | Thyromimetics | AUTOBAHN THERAPEUTICS, INC. (US) | 2023-06-06 | — | — | US | disclosed |
| US-11667606-B2 | Thyromimetics | AUTOBAHN THERAPEUTICS, INC. (US) | 2023-06-06 | — | — | US | disclosed |
| EP-4167986-A1 | THYROMIMETICS | Autobahn Therapeutics, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |
| EP-1541578-A1 | PROCESS FOR SELECTIVE PRODUCTION OF ARYL 5-THIO-BETA-D-ALDOHEXOPYRANOSIDES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2005-06-15 | — | — | EP | disclosed |
| EP-1528066-A1 | ARYL 5-THIO-D-GLUCOPYRANOSIDE DERIVATIVES AND REMEDIES FOR DIABETES CONTAINING THE SAME | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-20050085541-A1 | Novel thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2005-04-21 | — | — | US | disclosed |
| EP-1471049-A1 | NOVEL THYROID HORMONE RECEPTOR LIGAND, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND USE THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2004-10-27 | — | — | EP | disclosed |
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0540673-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0540673-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001682-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1992-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240294561-A1 | Prodrugs of Thyroid Hormone Analogs, Methods of Making and Methods of Using Thereof | THRB, THRA, TSHR | KEAP1 3878/4885HSPA5 3756/4885MPO 3989/4885 |
| US-11667606-B2 | Thyromimetics | TPO, TSHR, TTR | KEAP1 2106/4885HSPA5 3213/4885MPO 1959/4885 |
| US-20050085541-A1 | Novel thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof | TSHR, THRA, THRB | KEAP1 4101/4885HSPA5 2007/4885MPO 4829/4885 |
| US-20230242492-A1 | THYROMIMETICS | TPO, TSHR, THOP1 | KEAP1 867/4885HSPA5 479/4885MPO 3097/4885 |
| US-12590072-B2 | Thyromimetics | THRB, TSHR, TRHR | KEAP1 1497/4885HSPA5 1691/4885MPO 3118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.