SCHEMBL258356

SCHEMBL258356

CC1(C)COP(=S)(N(Cc2ccccc2)P2(=S)OCC(C)(C)CO2)OC1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.37
TSHR P16473 2/20 0.37
CA12 O43570 2/20 0.37
CA9 Q16790 2/20 0.37
CA2 P00918 2/20 0.37
CA1 P00915 1/20 0.37
AOC3 Q16853 1/20 0.35
NPSR1 Q6W5P4 4/20 0.35
KDM4E B2RXH2 2/20 0.35
ATM Q13315 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
OPRM1 P35372 1/20 0.34
OPRL1 P41146 1/20 0.34
MAPT P10636 2/20 0.34
HPGD P15428 2/20 0.34
HSD17B10 Q99714 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
MGLL Q99685 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2884181 0.90 CA12 (0.33) ALDH1A1TSHRCA12CA9CA2
SCHEMBL2941939 0.84 CA2 (0.34) ALDH1A1TSHRCA12CA9CA2
SCHEMBL258357 0.81 ADRA2B (0.38) ALDH1A1TSHRCA12CA9CA2
SCHEMBL2941933 0.73 TSHR (0.34) ALDH1A1TSHRCA12CA9CA2
SCHEMBL12212104 0.71 CA12 (0.35) CA12CA9CA2CA1CYP1A2
SCHEMBL11026913 0.70 TDP1 (0.33) ATMTDP1CYP1A2CYP2C9CYP2C19
SCHEMBL11044196 0.69 ALDH1A1 (0.38) ALDH1A1NPSR1MAPTHPGDHSD17B10
SCHEMBL11149674 0.68 GAA (0.34) ALDH1A1NPSR1CYP1A2CYP2C9CYP2C19
SCHEMBL23331403 0.67 ALDH1A1 (0.38) ALDH1A1NPSR1MAPTHPGDHSD17B10
SCHEMBL259021 0.66 ALDH1A1 (0.36) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2010513662-A 2010-04-30 JP claimed
EP-2125946-A2 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME Dow Global Technologies Inc. (US) 2009-12-02 EP claimed
WO-2008088487-A2 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME DOW GLOBAL TECHNOLOGIES, INC. (US) 2008-07-24 WO claimed
EP-2514788-B1 Phosphorus-sulfur flame retardant additives and polymer systems containing same DOW GLOBAL TECHNOLOGIES LLC (US) 2017-02-01 EP disclosed
EP-2514788-B1 Phosphorus-sulfur flame retardant additives and polymer systems containing same DOW GLOBAL TECHNOLOGIES LLC (US) 2017-02-01 EP disclosed
EP-2514788-A1 Phosphorus-sulfur flame retardant additives and polymer systems containing same Dow Global Technologies LLC (US) 2012-10-24 EP disclosed
EP-2514788-A1 Phosphorus-sulfur flame retardant additives and polymer systems containing same Dow Global Technologies LLC (US) 2012-10-24 EP disclosed
US-8058332-B2 Phosphorus-sulfur FR additives and polymer systems containing same DOW GLOBAL TECHNOLOGIES LLC (US) 2011-11-15 US disclosed
US-8058332-B2 Phosphorus-sulfur FR additives and polymer systems containing same DOW GLOBAL TECHNOLOGIES LLC (US) 2011-11-15 US disclosed
US-8058332-B2 Phosphorus-sulfur FR additives and polymer systems containing same DOW GLOBAL TECHNOLOGIES LLC (US) 2011-11-15 US disclosed
US-20110034573-A1 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME THE DOW CHEMICAL COMPANY 2011-02-10 US disclosed
US-20110034573-A1 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME THE DOW CHEMICAL COMPANY 2011-02-10 US disclosed
US-20110034573-A1 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME THE DOW CHEMICAL COMPANY 2011-02-10 US disclosed
EP-2125946-A2 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME Dow Global Technologies Inc. (US) 2009-12-02 EP disclosed
WO-2008088487-A2 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME DOW GLOBAL TECHNOLOGIES, INC. (US) 2008-07-24 WO disclosed
WO-2008088487-A2 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME DOW GLOBAL TECHNOLOGIES, INC. (US) 2008-07-24 WO disclosed
US-20080153950-A1 Phosphorus-sulfur FR additives and polymer systems containing same DCOMCO, INC. 2008-06-26 US disclosed
US-20080153950-A1 Phosphorus-sulfur FR additives and polymer systems containing same DCOMCO, INC. 2008-06-26 US disclosed
US-20080153950-A1 Phosphorus-sulfur FR additives and polymer systems containing same DCOMCO, INC. 2008-06-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080153950-A1 Phosphorus-sulfur FR additives and polymer systems containing same TST, FRG1, PFAS ALDH1A1 4394/4885TSHR 1687/4885CA12 2365/4885
US-20110034573-A1 PHOSPHORUS-SULFUR FR ADDITIVES AND POLYMER SYSTEMS CONTAINING SAME TST, FRG1, PFAS ALDH1A1 4394/4885TSHR 1687/4885CA12 2365/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.