Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2578534 | 0.91 | ACKR3 (0.40) | CTSSCTSKCES2CES1AAK1 | |
| SCHEMBL2588069 | 0.88 | AAK1 (0.34) | CTSSCTSKAAK1ACE | |
| SCHEMBL2584542 | 0.86 | CES2 (0.33) | CTSSCTSKCES2CES1AAK1 | |
| SCHEMBL2581151 | 0.83 | CHRNA1 (0.36) | CES2CES1AAK1HPGDMEN1 | |
| SCHEMBL2588125 | 0.83 | AAK1 (0.36) | CTSSCTSKAAK1RIPK1ACE | |
| SCHEMBL2587439 | 0.83 | CTSS (0.41) | CTSSCTSKCES2CES1HPGD | |
| SCHEMBL2585429 | 0.82 | CTSS (0.33) | CTSSCTSKAAK1ACE | |
| SCHEMBL2584672 | 0.81 | AAK1 (0.34) | CTSSCTSKCES2CES1AAK1 | |
| SCHEMBL2586648 | 0.80 | MEN1 (0.31) | CTSSCTSKMEN1KMT2AGAA | |
| SCHEMBL2575528 | 0.77 | ALDH1A1 (0.47) | DRD2HPGDMEN1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048878-B2 | Two cyclic cinnamide compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-11-01 | — | — | US | disclosed |