Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598467 | 0.82 | ADORA3 (0.38) | TGFBR1 | |
| SCHEMBL2598448 | 0.79 | TGFBR1 (0.40) | TGFBR1 | |
| SCHEMBL2598377 | 0.78 | MPO (0.35) | TGFBR1 | |
| SCHEMBL2598357 | 0.76 | MAPK1 (0.33) | TGFBR1 | |
| SCHEMBL2598332 | 0.73 | TGFBR1 (0.37) | TGFBR1 | |
| SCHEMBL2596818 | 0.70 | IRAK4 (0.38) | TGFBR1 | |
| SCHEMBL2598351 | 0.69 | NPBWR1 (0.49) | — | |
| SCHEMBL2598302 | 0.69 | DGAT1 (0.32) | — | |
| SCHEMBL2598454 | 0.67 | MET (0.43) | TGFBR1 | |
| SCHEMBL2598306 | 0.66 | PDE1B (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |