Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sapropterin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAH known ✓ | P00439 | 1/20 | 0.81 |
| ▸ | NOS1 | P29475 | 10/20 | 1.00 |
| ▸ | CASP7 | P55210 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.97 |
| ▸ | MAPT | P10636 | 2/20 | 0.97 |
| ▸ | BLM | P54132 | 2/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.97 |
| ▸ | GLA | P06280 | 1/20 | 0.97 |
| ▸ | HPGD | P15428 | 1/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.97 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.97 |
| ▸ | NOS3 | P29474 | 3/20 | 0.62 |
| ▸ | NOS2 | P35228 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RGS12 | O14924 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sapropterin SCHEMBL21068033 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL4217501 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL29538547 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL29351671 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL7942378 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL29059706 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL14072498 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL14401407 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL31106620 | 0.99 | KDM4E (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL1070424 | 0.99 | KDM4E (1.00) | NOS1CASP7HSD17B10USP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1445 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260148848-A1 | BIOMARKERS FOR DIAGNOSIS AND TREATMENT OF ENDOCRINE HYPERTENSION, AND METHODS OF IDENTIFICATION THEREOF | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2026-05-28 | — | — | US | claimed |
| CN-122079949-A | Near-infrared xanthene dye with adjustable structural symmetry and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122059999-A | Sulfur/carbon ligand bridged bimetallic complex, preparation method thereof and application thereof in dehalogenation of chloro/bromo alkane into corresponding alkane or alkene | 大连理工大学 | 2026-05-19 | — | — | CN | claimed |
| CN-122030342-A | Construction and maintenance method of brown planthopper pest-caused experimental population | 广西壮族自治区农业科学院 | 2026-05-15 | — | — | CN | claimed |
| EP-4735457-A2 | E-SELECTIVE METATHESIS CATALYSTS | Verbio SE (DE) | 2026-05-06 | — | — | EP | claimed |
| US-20250372660-A1 | HIGH-ENERGY LITHIUM METAL BATTERIES ACHIEVED BY INORGANIC AND ORGANIC COATINGS | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2025-12-04 | — | — | US | claimed |
| EP-4642770-A1 | TRIARYLSULFONIUM BASED PHOTOINITIATORS FOR LED CURE OF CATIONIC, FREE RADICAL AND HYBRID CATIONIC/FREE RADICAL FORMULATIONS | ARKEMA France (FR) | 2025-11-05 | — | — | EP | claimed |
| US-12404221-B2 | Methods of arene alkenylation | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2025-09-02 | — | — | US | claimed |
| US-20250262613-A1 | RARE EARTH AND GROUP 4 CATALYSTS FOR AMBIENT CONVERSION OF DINITROGEN TO SECONDARY SILYLAMINES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-08-21 | — | — | US | claimed |
| US-20250206918-A1 | COMPOSITIONS AND METHODS FOR THE FABRICATION OF SUPRAMOLECULAR MATERIALS WITH NANOSTRUCTURES AND SPATIALLY DISTINCT FEATURES | THE UNIVERSITY OF HONG KONG (CN) | 2025-06-26 | — | — | US | claimed |
| CN-112812230-B | Catalytic load polymer and preparation method and application thereof | 浙江大学 | 2022-03-25 | — | — | CN | claimed |
| WO-2022056272-A1 | ORGANO-ALUMINUM ANALYTES FOR NONAQUEOUS REDOX FLOW BATTERIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-03-17 | — | — | WO | claimed |
| CN-114163627-A | Double-function double-metal catalyst and its application | 大连理工大学 | 2022-03-11 | — | — | CN | claimed |
| US-11260379-B2 | Catalysts and methods for epoxide-based polymerizations | CORNELL UNIVERSITY (US) | 2022-03-01 | — | — | US | claimed |
| US-11248074-B2 | Method for producing copolymer of polar group-containing allyl monomer | THE UNIVERSITY OF TOKYO (JP) | 2022-02-15 | — | — | US | claimed |
| CN-112851924-B | Recyclable nitrogen-containing polycarbonate plastic synthesis method | 大连理工大学 | 2022-02-15 | — | — | CN | claimed |
| CN-114040962-A | Red fluorescence emitting compounds for organelle imaging | 香港科技大学 | 2022-02-11 | — | — | CN | claimed |
| US-20220033740-A1 | STAIN REMOVAL THROUGH NOVEL OXIDIZER AND CHELANT COMBINATION | ECOLAB USA INC. | 2022-02-03 | — | — | US | claimed |
| US-20170042899-A1 | Use of Tetrahydrobiopterine Derivatives in the Treatment and Nutrition of Patients With Amino Acid Metabolic Disorders | BIOMARIN PHARM INC (US) | 2017-02-16 | — | — | US | claimed |
| US-20060211701-A1 | Use of von tetrahydrobiopterine derivatives in the treatment and nutrition of patients with amino acid metabolic disorders | BIOMARIN PHARMACEUTICAL INC. | 2006-09-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211701-A1 | Use of von tetrahydrobiopterine derivatives in the treatment and nutrition of patients with amino acid metabolic disorders | PAH, BCAT1, AADAT | PAH 1/4885NOS1 671/4885CASP7 4768/4885 |
| US-20250206918-A1 | COMPOSITIONS AND METHODS FOR THE FABRICATION OF SUPRAMOLECULAR MATERIALS WITH NANOSTRUCTURES AND SPATIALLY DISTINCT FEATURES | VCL, PICALM, SOD1 | PAH 2648/4885NOS1 1634/4885CASP7 1998/4885 |
| US-12404221-B2 | Methods of arene alkenylation | CYBB, CBR3, AHR | PAH 264/4885NOS1 2135/4885CASP7 799/4885 |
| US-20260148848-A1 | BIOMARKERS FOR DIAGNOSIS AND TREATMENT OF ENDOCRINE HYPERTENSION, AND METHODS OF IDENTIFICATION THEREOF | SHBG, HSD11B2, HSD11B1 | PAH 83/4885NOS1 331/4885CASP7 4485/4885 |
| US-20170042899-A1 | Use of Tetrahydrobiopterine Derivatives in the Treatment and Nutrition of Patients With Amino Acid Metabolic Disorders | PAH, AADAT, BCAT1 | PAH 1/4885NOS1 545/4885CASP7 4674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.