Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sapropterin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAH known ✓ | P00439 | 1/20 | 0.81 |
| ▸ | NOS1 | P29475 | 10/20 | 1.00 |
| ▸ | CASP7 | P55210 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.97 |
| ▸ | MAPT | P10636 | 2/20 | 0.97 |
| ▸ | BLM | P54132 | 2/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.97 |
| ▸ | GLA | P06280 | 1/20 | 0.97 |
| ▸ | HPGD | P15428 | 1/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.97 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.97 |
| ▸ | NOS3 | P29474 | 3/20 | 0.62 |
| ▸ | NOS2 | P35228 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RGS12 | O14924 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sapropterin SCHEMBL21068033 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL4217501 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL29538547 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL7942378 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL29059706 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL14072498 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL260185 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL14401407 | 1.00 | NOS1 (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL31106620 | 0.99 | KDM4E (1.00) | NOS1CASP7HSD17B10USP2KDM4E | |
| Sapropterin SCHEMBL1070424 | 0.99 | KDM4E (1.00) | NOS1CASP7HSD17B10USP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 240 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111712938-B | Organic electroluminescent element and electronic device | 出光兴产株式会社 | 2025-01-14 | — | — | CN | claimed |
| US-20250006293-A1 | METHODS FOR ANTIBODY OPTIMIZATION | VIBRANT PHARMA LIMITED (CN) | 2025-01-02 | — | — | US | claimed |
| EP-4408878-A1 | METHODS FOR ANTIBODY OPTIMIZATION | Vibrant Pharma Limited (CN) | 2024-08-07 | — | — | EP | claimed |
| CN-118176208-A | Antibody optimization method | 信华生物药业(广州)有限公司 | 2024-06-11 | — | — | CN | claimed |
| WO-2023096387-A1 | NOVEL ORGANIC ANTHRACENE COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME | 에스에프씨 주식회사 | 2023-06-01 | — | — | WO | claimed |
| WO-2023096399-A1 | HIGH EFFICIENCY AND LONG LIFETIME ORGANIC LIGHT-EMITTING DIODE | 에스에프씨 주식회사 | 2023-06-01 | — | — | WO | claimed |
| WO-2023078420-A1 | METHODS FOR ANTIBODY OPTIMIZATION | VIBRANT PHARMA LIMITED (CN) | 2023-05-11 | — | — | WO | claimed |
| US-20260117288-A1 | METHODS FOR SPECIFIC DETECTION OF NUCLEIC ACID SEQUENCES USING IN VITRO TRANSCRIPTION AND IN SITU SEQUENCING | WAYPOINT BIO INC (US) | 2026-04-30 | — | — | US | disclosed |
| US-20260096282-A1 | ORGANIC LIGHT EMITTING DIODE WITH LOW VOLTAGE, HIGH EFFICIENCY AND LONG LIFESPAN | SFC CO LTD (KR) | 2026-04-02 | — | — | US | disclosed |
| US-20260071120-A1 | NOVEL COMPOUND, ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME, AND ELECTRONIC APPARATUS | IDEMITSU KOSAN CO ., LTD. (JP) | 2026-03-12 | — | — | US | disclosed |
| US-20260068520-A1 | ORGANIC LIGHT-EMITTING DIODE WITH LOW VOLTAGE, HIGH EFFICIENCY AND LONG LIFESPAN | SFC CO LTD (KR) | 2026-03-05 | — | — | US | disclosed |
| EP-4704532-A1 | AN ORGANIC LIGHT EMITTING DIODE WITH LOW VOLTAGE, HIGH EFFICIENCY AND LONG LIFESPAN | SFC Co., Ltd. (KR) | 2026-03-04 | — | — | EP | disclosed |
| EP-4704538-A1 | AN ORGANIC LIGHT EMITTING DIODE WITH LOW VOLTAGE, HIGH EFFICIENCY AND LONG LIFESPAN | SFC Co., Ltd. (KR) | 2026-03-04 | — | — | EP | disclosed |
| US-20220069223-A1 | ORGANIC LIGHT-EMITTING DEVICE | LG CHEM, LTD. (KR) | 2022-03-03 | — | — | US | disclosed |
| EP-3604457-B1 | AQUEOUS INK COMPOSITION, INK SET, IMAGE FORMING METHOD, AND RESIN MICROPARTICLES FOR INK | FUJIFILM CORP (JP) | 2022-02-09 | — | — | EP | disclosed |
| CN-114026147-A | Polycyclic aromatic compound | 学校法人关西学院 | 2022-02-08 | — | — | CN | disclosed |
| CN-113994497-A | Organic light emitting device | 株式会社LG化学 | 2022-01-28 | — | — | CN | disclosed |
| CN-113991029-A | Blue light organic electroluminescent device and display device comprising same | 京东方科技集团股份有限公司 | 2022-01-28 | — | — | CN | disclosed |
| US-20220029099-A1 | NOVEL COMPOUND, AND ORGANIC ELECTROLUMINESCENCE DEVICE AND ELECTRONIC APPARATUS USING THE SAME | IDEMITSU KOSAN CO.,LTD. (JP) | 2022-01-27 | — | — | US | disclosed |
| CN-113966327-A | Compound and organic light-emitting element comprising same | 株式会社LG化学 | 2022-01-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260117288-A1 | METHODS FOR SPECIFIC DETECTION OF NUCLEIC ACID SEQUENCES USING IN VITRO TRANSCRIPTION AND IN SITU SEQUENCING | RNGTT, CPSF1, FBL | PAH 3076/4885NOS1 4484/4885CASP7 1444/4885 |
| US-20260068520-A1 | ORGANIC LIGHT-EMITTING DIODE WITH LOW VOLTAGE, HIGH EFFICIENCY AND LONG LIFESPAN | CRY1, CRY2, ELOVL1 | PAH 416/4885NOS1 619/4885CASP7 3246/4885 |
| US-20260071120-A1 | NOVEL COMPOUND, ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME, AND ELECTRONIC APPARATUS | CLIC1, NAP1L1, ARL1 | PAH 3133/4885NOS1 1027/4885CASP7 3626/4885 |
| US-20260096282-A1 | ORGANIC LIGHT EMITTING DIODE WITH LOW VOLTAGE, HIGH EFFICIENCY AND LONG LIFESPAN | AHR, CRY1, CRY2 | PAH 128/4885NOS1 2108/4885CASP7 3123/4885 |
| US-20220029099-A1 | NOVEL COMPOUND, AND ORGANIC ELECTROLUMINESCENCE DEVICE AND ELECTRONIC APPARATUS USING THE SAME | RER1, RIF1, RPS19 | PAH 1947/4885NOS1 3594/4885CASP7 4164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.