SCHEMBL2634478

SCHEMBL2634478

NCCNC(=O)c1nc(N)c(C(=O)NCCN)nc1N

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.44
ALDH1A1 P00352 1/20 0.44
HSD17B10 Q99714 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
MAOB P27338 3/20 0.43
CYP1A2 P05177 2/20 0.43
TSHR P16473 1/20 0.43
NFKB1 P19838 1/20 0.43
KMT2A Q03164 3/20 0.42
PMP22 Q01453 2/20 0.42
MEN1 O00255 1/20 0.42
BLM P54132 1/20 0.42
TERT O14746 2/20 0.39
CHEK1 O14757 1/20 0.38
CHEK2 O96017 1/20 0.38
CYP3A4 P08684 1/20 0.38
THPO P40225 1/20 0.38
LMNA P02545 1/20 0.37
NQO2 P16083 1/20 0.35
ADORA2A P29274 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2634079 0.98 KMT2A (0.44) KDM4EALDH1A1HSD17B10L3MBTL1MAOB
SCHEMBL16748713 0.91 GABRG2 (0.41) KDM4EALDH1A1HSD17B10L3MBTL1MAOB
Trifluoroacetic Acid SCHEMBL30286292 0.89 CSNK1D (0.43) KDM4EALDH1A1HSD17B10L3MBTL1MAOB
SCHEMBL9608994 0.88 KDM4E (0.43) KDM4EALDH1A1HSD17B10L3MBTL1KMT2A
SCHEMBL1429031 0.86 SCNN1A (0.50) KDM4EALDH1A1HSD17B10MAOBCYP1A2
SCHEMBL15185777 0.82 KDM4E (0.43) KDM4EALDH1A1HSD17B10L3MBTL1KMT2A
SCHEMBL18230698 0.80 CA1 (0.42) KDM4EALDH1A1HSD17B10L3MBTL1LMNA
SCHEMBL12184961 0.79 HPGD (0.38) KDM4EALDH1A1HSD17B10L3MBTL1TSHR
SCHEMBL12997160 0.78 SMN1; SMN2 (0.41) KDM4EALDH1A1HSD17B10L3MBTL1KMT2A
Hydrochloric Acid SCHEMBL2634029 0.78 HPGD (0.38) KDM4EALDH1A1HSD17B10L3MBTL1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3700578-B1 SYSTEMS FOR RENAL FUNCTION DETERMINATION MEDIBEACON INC (US) 2025-12-03 EP disclosed
EP-3917378-B1 SYSTEMS AND METHODS FOR HOME TRANSDERMAL GFR MONITORING MEDIBEACON INC (US) 2025-01-08 EP disclosed
US-11969268-B2 Systems and methods for home transdermal assessment of gastrointestinal function MEDIBEACON INC. (US) 2024-04-30 US disclosed
CN-116348755-A System and method for home percutaneous assessment of gastrointestinal function 麦迪贝肯有限公司 2023-06-27 CN disclosed
US-20230173111-A1 COMPOSITIONS AND SYSTEMS FOR RENAL FUNCTION DETERMINATION MEDIBEACON INC. 2023-06-08 US disclosed
US-20230173111-A1 COMPOSITIONS AND SYSTEMS FOR RENAL FUNCTION DETERMINATION MEDIBEACON INC. 2023-06-08 US disclosed
EP-4185194-A1 SYSTEMS AND METHODS FOR HOME TRANSDERMAL ASSESSMENT OF GASTROINTESTINAL FUNCTION MediBeacon Inc. (US) 2023-05-31 EP disclosed
US-20230158175-A1 METHODS FOR RENAL FUNCTION DETERMINATION MEDIBEACON INC. 2023-05-25 US disclosed
US-20230158175-A1 METHODS FOR RENAL FUNCTION DETERMINATION MEDIBEACON INC. 2023-05-25 US disclosed
CN-111481218-B System and method for home transdermal GFR monitoring 麦迪贝肯有限公司 2023-04-28 CN disclosed
US-20100105899-A1 Integrated Photoactive Small Molecules and Uses Thereof MEDIBEACON, INC. 2010-04-29 US disclosed
US-20100105899-A1 Integrated Photoactive Small Molecules and Uses Thereof MEDIBEACON, INC. 2010-04-29 US disclosed
EP-2131861-A2 INTEGRATED PHOTOACTIVE SMALL MOLECULES AND USES THEREOF Mallinckrodt Inc. (US) 2009-12-16 EP disclosed
US-20090198053-A1 Pyrazine Derivatives and Uses Thereof in Renal Monitoring MEDIBEACON INC. 2009-08-06 US disclosed
US-20090198053-A1 Pyrazine Derivatives and Uses Thereof in Renal Monitoring MEDIBEACON INC. 2009-08-06 US disclosed
US-20090198053-A1 Pyrazine Derivatives and Uses Thereof in Renal Monitoring MEDIBEACON INC. 2009-08-06 US disclosed
WO-2009061473-A2 PHOTONIC SHELL-CORE CROSS LINKED AND FUNCTIONALIZED NANOSTRUCTURES FOR BIOLOGICAL APPLICATIONS MALLINCKRODT INC. (US) 2009-05-14 WO disclosed
WO-2009061473-A2 PHOTONIC SHELL-CORE CROSS LINKED AND FUNCTIONALIZED NANOSTRUCTURES FOR BIOLOGICAL APPLICATIONS MALLINCKRODT INC. (US) 2009-05-14 WO disclosed
WO-2008108944-A2 INTEGRATED PHOTOACTIVE SMALL MOLECULES AND USES THEREOF MALLINCKRODT INC. (US) 2008-09-12 WO disclosed
WO-2008108944-A2 INTEGRATED PHOTOACTIVE SMALL MOLECULES AND USES THEREOF MALLINCKRODT INC. (US) 2008-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230173111-A1 COMPOSITIONS AND SYSTEMS FOR RENAL FUNCTION DETERMINATION GLS, ATP6V1B1, REN KDM4E 4756/4885ALDH1A1 3528/4885HSD17B10 4551/4885
US-20100105899-A1 Integrated Photoactive Small Molecules and Uses Thereof TYR, UACA, TH KDM4E 3110/4885ALDH1A1 640/4885HSD17B10 3139/4885
US-20090198053-A1 Pyrazine Derivatives and Uses Thereof in Renal Monitoring GLS, CYP3A5, PYCR1 KDM4E 2058/4885ALDH1A1 268/4885HSD17B10 2153/4885
US-20230158175-A1 METHODS FOR RENAL FUNCTION DETERMINATION GLS, SHBG, OGFR KDM4E 4201/4885ALDH1A1 1776/4885HSD17B10 3082/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.