Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12456100 | 0.94 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2MMP2MMP9MMP3 | |
| SCHEMBL265660 | 0.85 | MMP2 (0.41) | ALDH1A1SMN1; SMN2MMP2MMP9MMP3 | |
| SCHEMBL265305 | 0.84 | LMNA (0.36) | ALDH1A1SMN1; SMN2MMP2MMP9MMP3 | |
| SCHEMBL300244 | 0.84 | MEN1 (0.52) | ALDH1A1SMN1; SMN2MMP2MMP9MMP3 | |
| SCHEMBL265249 | 0.82 | MMP2 (0.40) | SMN1; SMN2MMP2MMP9MMP3MMP8 | |
| SCHEMBL12457026 | 0.80 | MMP2 (0.40) | SMN1; SMN2MMP2MMP9MMP3MMP8 | |
| SCHEMBL301236 | 0.80 | MMP2 (0.43) | ALDH1A1SMN1; SMN2MMP2MMP9MMP3 | |
| SCHEMBL264852 | 0.80 | MMP2 (0.54) | MMP2MMP9MMP3MMP8MMP13 | |
| SCHEMBL13889219 | 0.79 | NAMPT (0.33) | MMP2MMP9MMP3KDM4EMMP8 | |
| SCHEMBL264568 | 0.79 | MMP2 (0.43) | ALDH1A1SMN1; SMN2MMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133743-B2 | Phenobarbital derivatives useful in immunoassay | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-8133743-B2 | Phenobarbital derivatives useful in immunoassay | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-8133743-B2 | Phenobarbital derivatives useful in immunoassay | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| EP-2205571-B1 | PHENOBARBITAL DERIVATIVES USEFUL IN IMMUNOASSAY | ROCHE DIAGNOSTICS GMBH (DE) | 2011-08-31 | — | — | EP | disclosed |
| EP-2205571-B1 | PHENOBARBITAL DERIVATIVES USEFUL IN IMMUNOASSAY | ROCHE DIAGNOSTICS GMBH (DE) | 2011-08-31 | — | — | EP | disclosed |
| EP-2205571-A1 | PHENOBARBITAL DERIVATIVES USEFUL IN IMMUNOASSAY | Roche Diagnostics GmbH (DE) | 2010-07-14 | — | — | EP | disclosed |
| US-20090104713-A1 | Phenobarbital derivatives useful in immunoassay | ROCHE DIAGNOSTICS OPERATIONS, INC. | 2009-04-23 | — | — | US | disclosed |
| US-20090104713-A1 | Phenobarbital derivatives useful in immunoassay | ROCHE DIAGNOSTICS OPERATIONS, INC. | 2009-04-23 | — | — | US | disclosed |
| US-20090104713-A1 | Phenobarbital derivatives useful in immunoassay | ROCHE DIAGNOSTICS OPERATIONS, INC. | 2009-04-23 | — | — | US | disclosed |
| WO-2009049884-A1 | PHENOBARBITAL DERIVATIVES USEFUL IN IMMUNOASSAY | ROCHE DIAGNOSTICS GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009049884-A1 | PHENOBARBITAL DERIVATIVES USEFUL IN IMMUNOASSAY | ROCHE DIAGNOSTICS GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090104713-A1 | Phenobarbital derivatives useful in immunoassay | PGM2, CYP4F2, CYP3A7 | ALDH1A1 2508/4885SMN1; SMN2 3699/4885MMP2 1480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.