Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | CMA1 | P23946 | 3/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CLIC1 | O00299 | 1/20 | 0.34 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.34 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27374878 | 0.77 | HSD17B10 (0.42) | PTGDR2PTGS2KDM4EMEN1ALDH1A1 | |
| SCHEMBL6977262 | 0.77 | AGBL2 (0.39) | PTGDR2PTGS2KDM4EMEN1ALDH1A1 | |
| Cyclopropane SCHEMBL11665858 | 0.76 | ADRA1D (0.36) | PTGDR2PTGS2KDM4EMEN1ALDH1A1 | |
| SCHEMBL2986172 | 0.75 | — | — | |
| SCHEMBL6561734 | 0.74 | ALDH1A1 (0.35) | PTGDR2KEAP1NFE2L2MEN1ALDH1A1 | |
| SCHEMBL28007558 | 0.74 | THRB (0.34) | PTGDR2KEAP1NFE2L2KDM4EMEN1 | |
| SCHEMBL21737582 | 0.73 | — | — | |
| SCHEMBL11348514 | 0.72 | PTGS2 (0.56) | PTGS2KMT2AAKR1B1CLIC1CXCL8 | |
| SCHEMBL11348988 | 0.71 | PTGS2 (0.58) | PTGS2MEN1ALDH1A1KMT2ACLIC1 | |
| SCHEMBL15532260 | 0.71 | DAO (0.33) | MCL1CMA1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090088584-A1 | PROCESS FOR PREPARING 3, 4-DISUBSTITUTED PHENYLACETIC ACIDS AND NOVEL INTERMEDIATES | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2009-04-02 | — | — | US | disclosed |
| EP-1986995-A1 | PROCESS FOR PREPARING 3, 4-DISUBSTITUTED PHENYLACETIC ACIDS AND NOVEL INTERMEDIATES | DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) | 2008-11-05 | — | — | EP | disclosed |
| US-20070284258-A1 | Method For Silver Plating | DAIWA FINE CHEMICALS CO., LTD. (JP) | 2007-12-13 | — | — | US | disclosed |
| US-20070254895-A1 | Crystalline solvate of glucokinase activator | CHOI DUK SOON | 2007-11-01 | — | — | US | disclosed |
| WO-2007115968-A2 | PROCESS FOR THE PREPARATION OF A GLUCOKINASE ACTIVATOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007115967-A1 | CRYSTALLINE ISOPROPANOL SOLVATE OF GLUCOKINASE ACTIVATOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |
| US-20070244129-A1 | Process for the preparation of an isopropanol solvate of a glucokinase activator | DANIEWSKI ANDRZEJ ROBERT | 2007-10-18 | — | — | US | disclosed |
| WO-2007096034-A1 | PROCESS FOR PREPARING 3, 4-DISUBSTITUTED PHENYLACETIC ACIDS AND NOVEL INTERMEDIATES | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088584-A1 | PROCESS FOR PREPARING 3, 4-DISUBSTITUTED PHENYLACETIC ACIDS AND NOVEL INTERMEDIATES | PAH, CTRC, DDC | PTGDR2 1711/4885MCL1 3238/4885PTGS2 4066/4885 |
| US-20070244129-A1 | Process for the preparation of an isopropanol solvate of a glucokinase activator | GCKR, GCK, GK | PTGDR2 1354/4885MCL1 4404/4885PTGS2 915/4885 |
| US-20070254895-A1 | Crystalline solvate of glucokinase activator | GCKR, GCK, PDXK | PTGDR2 2173/4885MCL1 4706/4885PTGS2 1331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.