Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 3/20 | 0.58 |
| ▸ | PRNP | P04156 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895763 | 0.88 | FABP4 (0.68) | FABP4PRNPKMT2AHNF4AALDH1A1 | |
| SCHEMBL27950189 | 0.85 | FABP4 (0.55) | FABP4PRNPHNF4AALDH1A1MAPT | |
| SCHEMBL28289664 | 0.80 | FABP4 (0.55) | FABP4MEN1KMT2AALDH1A1HTT | |
| SCHEMBL27933541 | 0.80 | FABP4 (0.51) | FABP4PRNPMEN1KMT2AHNF4A | |
| SCHEMBL8973903 | 0.78 | ALDH1A1 (0.55) | FABP4MEN1KMT2AALDH1A1HTT | |
| SCHEMBL8778491 | 0.78 | HNF4A (0.60) | FABP4MEN1KMT2AHNF4AALDH1A1 | |
| SCHEMBL28789332 | 0.77 | FABP4 (0.47) | FABP4PRNPMEN1KMT2AHNF4A | |
| SCHEMBL11625438 | 0.77 | WDR5 (0.51) | FABP4PRNPMEN1KMT2AALDH1A1 | |
| SCHEMBL6748515 | 0.76 | MAPT (0.52) | FABP4MEN1KMT2AHNF4AALDH1A1 | |
| SCHEMBL28409589 | 0.76 | FABP4 (0.58) | FABP4MEN1KMT2AHNF4AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173696-B2 | Inhibitors of cysteine proteases and methods of use thereof | BAYLOR UNIVERSITY (US) | 2012-05-08 | — | — | US | disclosed |
| US-20090076076-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | BAYLOR UNIVERSITY (US) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076076-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | CTSB, CTSS, CTSZ | FABP4 3879/4885PRNP 1693/4885MEN1 2515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.