Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.54 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | GGT1 | P19440 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380299 | 0.84 | HSD17B10 (0.59) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| Aspirin SCHEMBL3731927 | 0.82 | KDM4E (0.70) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL3667204 | 0.81 | HSD17B10 (0.65) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL1868204 | 0.81 | KDM4E (0.63) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL8647889 | 0.80 | LMNA (0.50) | HSD17B10KDM4ELMNAHPGDALDH1A1 | |
| SCHEMBL2780216 | 0.78 | HSD17B10 (0.59) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL7606600 | 0.78 | HSD17B10 (0.59) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL11019069 | 0.78 | HSD17B10 (0.59) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL1821600 | 0.78 | HSD17B10 (0.59) | HSD17B10KDM4ELMNACYP1A2CYP2C9 | |
| SCHEMBL13725644 | 0.78 | PTGS2 (0.53) | HSD17B10KDM4ELMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563776-B2 | L-Threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2013-10-22 | — | — | US | disclosed |
| US-8563776-B2 | L-Threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2013-10-22 | — | — | US | disclosed |
| US-8563776-B2 | L-Threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120289471-A1 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-11-15 | — | — | US | disclosed |
| US-20120289471-A1 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-11-15 | — | — | US | disclosed |
| US-20120289471-A1 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-11-15 | — | — | US | disclosed |
| US-8188311-B2 | L-threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188311-B2 | L-threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188311-B2 | L-threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-05-29 | — | — | US | disclosed |
| US-8173840-B2 | Compounds with high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-05-08 | — | — | US | disclosed |
| US-20100004481-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS (US) | 2010-01-07 | — | — | US | disclosed |
| US-20100004481-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS (US) | 2010-01-07 | — | — | US | disclosed |
| US-20100004481-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS (US) | 2010-01-07 | — | — | US | disclosed |
| US-7589233-B2 | L-Threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2009-09-15 | — | — | US | disclosed |
| US-7589233-B2 | L-Threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2009-09-15 | — | — | US | disclosed |
| US-7589233-B2 | L-Threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2009-09-15 | — | — | US | disclosed |
| WO-2007089745-A2 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | SIGNATURE R & D HOLDINGS, LLC (US) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007089745-A2 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | SIGNATURE R & D HOLDINGS, LLC (US) | 2007-08-09 | — | — | WO | disclosed |
| US-20060287244-A1 | L-Threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC | 2006-12-21 | — | — | US | disclosed |
| US-20060241017-A1 | Novel compounds with high therapeutic index | SIGNATURE R&D HOLDINGS, LLC | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004481-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | BCAT1, AADAT, TPI1 | HSD17B10 921/4885KDM4E 1929/4885LMNA 3998/4885 |
| US-20060287244-A1 | L-Threonine derivatives of high therapeutic index | BCAT1, AADAT, TPI1 | HSD17B10 921/4885KDM4E 1929/4885LMNA 3998/4885 |
| US-20120289471-A1 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | IL4I1, SLC7A1, GOT1 | HSD17B10 203/4885KDM4E 2627/4885LMNA 4367/4885 |
| US-20060241017-A1 | Novel compounds with high therapeutic index | IL4I1, SLC7A1, GOT1 | HSD17B10 203/4885KDM4E 2627/4885LMNA 4367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.