Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Trifluoroacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 3/20 | 0.38 |
| ▸ | PGK2 | P07205 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL28656139 | 0.94 | PGK1 (0.35) | PGK1PGK2ALDH1A1L3MBTL1PTPN1 | |
| Trifluoroacetic Acid SCHEMBL28679728 | 0.94 | ALDH1A1 (0.35) | PGK1PGK2ALDH1A1L3MBTL1PTPN1 | |
| Trifluoroacetic Acid SCHEMBL4430504 | 0.90 | PGK1 (0.36) | PGK1PGK2ALDH1A1L3MBTL1PTPN1 | |
| Trifluoroacetic Acid SCHEMBL30657022 | 0.84 | — | — | |
| Trifluoroacetic Acid SCHEMBL7814389 | 0.84 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1THRBTSHRMEN1 | |
| Trifluoroacetic Acid SCHEMBL4598430 | 0.84 | — | — | |
| Trifluoroacetic Acid SCHEMBL474 | 0.84 | — | — | |
| Trifluoroacetic Acid SCHEMBL2484766 | 0.84 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1THRBTSHRMEN1 | |
| Trifluoroacetic Acid SCHEMBL28463674 | 0.84 | SLC34A1 (0.44) | PGK1PGK2ALDH1A1L3MBTL1PTPN1 | |
| Trifluoroacetic Acid SCHEMBL25297651 | 0.81 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1THRBTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240425517-A1 | NOVEL COMPOUND FOR DEGRADATION OF TARGET PROTEIN OR POLYPEPTIDE BY POLYUBIQUITINATION | PRAZER THERAPEUTICS INC. (KR) | 2024-12-26 | — | — | US | disclosed |
| CN-118619945-A | KIF18A inhibitors and uses thereof | 诺沃斯达药业(上海)有限公司 | 2024-09-10 | — | — | CN | disclosed |
| CN-115128197-A | Method for determining concentration of gentamicin by LC-MS/MS | 河北远征禾木药业有限公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-113881685-A | Gene PpHSP20-like1 for promoting plant organs to generate red color and application thereof | 江苏省农业科学院 | 2022-01-04 | — | — | CN | disclosed |
| CN-113272302-A | Antibiotic compounds, process for their manufacture, pharmaceutical compositions containing them and their use | 德彪药业国际股份公司 | 2021-08-17 | — | — | CN | disclosed |
| US-9186302-B2 | Biomaterial compositions | CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2015-11-17 | — | — | US | disclosed |
| US-20130210953-A1 | BIOMATERIAL COMPOSITIONS | CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2013-08-15 | — | — | US | disclosed |
| WO-2012058591-A1 | BIOMATERIAL COMPOSITIONS | CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2012-05-03 | — | — | WO | disclosed |
| EP-1809603-A4 | NITROBENZINDOLES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LTD (NZ) | 2009-09-02 | — | — | EP | disclosed |
| EP-1809603-A1 | NITROBENZINDOLES AND THEIR USE IN CANCER THERAPY | Auckland Uniservices Limited (NZ) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006043839-A1 | NITROBENZINDOLES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240425517-A1 | NOVEL COMPOUND FOR DEGRADATION OF TARGET PROTEIN OR POLYPEPTIDE BY POLYUBIQUITINATION | ADRM1, SUMO1, SUMO2 | PGK1 1444/4885PGK2 1971/4885ALDH1A1 3989/4885 |
| US-20130210953-A1 | BIOMATERIAL COMPOSITIONS | CAD, ALOX5, PGLS | PGK1 1820/4885PGK2 2064/4885ALDH1A1 696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.