Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 10/20 | 0.83 |
| ▸ | ACHE | P22303 | 10/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.83 |
| ▸ | LMNA | P02545 | 2/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.83 |
| ▸ | MAPT | P10636 | 2/20 | 0.83 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.83 |
| ▸ | DRD2 | P14416 | 2/20 | 0.83 |
| ▸ | TSHR | P16473 | 2/20 | 0.83 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.83 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.83 |
| ▸ | RXRA | P19793 | 2/20 | 0.83 |
| ▸ | DRD1 | P21728 | 2/20 | 0.83 |
| ▸ | HTR2B | P41595 | 2/20 | 0.83 |
| ▸ | HTT | P42858 | 2/20 | 0.83 |
| ▸ | RAD52 | P43351 | 2/20 | 0.83 |
| ▸ | EP300 | Q09472 | 2/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26621113 | 0.92 | BCHE (0.80) | BCHEACHEALDH1A1LMNACYP3A4 | |
| SCHEMBL18645302 | 0.92 | — | — | |
| Berberine SCHEMBL30153843 | 0.91 | ACHE (1.00) | BCHEACHEALDH1A1LMNACYP3A4 | |
| Berberine SCHEMBL29354144 | 0.91 | ACHE (1.00) | BCHEACHEALDH1A1LMNACYP3A4 | |
| Berberine SCHEMBL15669190 | 0.91 | ACHE (1.00) | BCHEACHEALDH1A1LMNACYP3A4 | |
| Berberine SCHEMBL25632 | 0.91 | ACHE (1.00) | BCHEACHEALDH1A1LMNACYP3A4 | |
| Berberine SCHEMBL3691964 | 0.90 | BCHE (0.90) | BCHEACHEALDH1A1LMNACYP3A4 | |
| Berberine SCHEMBL4894622 | 0.90 | BCHE (0.98) | BCHEACHEALDH1A1LMNACYP3A4 | |
| Berberine SCHEMBL2538316 | 0.90 | ACHE (0.98) | BCHEACHEALDH1A1LMNACYP3A4 | |
| Berberine SCHEMBL3686644 | 0.90 | ACHE (0.98) | BCHEACHEALDH1A1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370434-B1 | ISOQUINOLINYL-CONTAINING ALKALOID COMPOUNDS AND COMPOSITIONS USEFUL FOR REDUCING LIPID LEVELS | CVI PHARMACEUTICALS LTD (KY) | 2014-09-17 | — | — | EP | disclosed |
| US-8815900-B2 | Compounds and compositions for reducing lipid levels | CVI PHARMACEUTICALS LIMITED (KY) | 2014-08-26 | — | — | US | disclosed |
| US-8710071-B2 | Compounds, compositions and methods for reducing lipid levels | CVI PHARMACEUTICALS LIMITED (KY) | 2014-04-29 | — | — | US | disclosed |
| US-20120004223-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR REDUCING LIPID LEVELS | CVI PHARMACEUTICALS LIMITED (KY) | 2012-01-05 | — | — | US | disclosed |
| US-20110269754-A1 | COMPOUNDS AND COMPOSITIONS FOR REDUCING LIPID LEVELS | CVI PHARMACEUTICALS LIMITED (KY) | 2011-11-03 | — | — | US | disclosed |
| US-8003795-B2 | Compounds and compositions for reducing lipid levels | CVI PHARMACEUTICALS LIMITED (KY) | 2011-08-23 | — | — | US | disclosed |
| US-20090048246-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR REDUCING LIPID LEVELS | CVI PHARMACEUTICALS LIMITED (KY) | 2009-02-19 | — | — | US | disclosed |
| US-20070098649-A1 | Method and composition for controlling oral pathogens | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (IL) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004223-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR REDUCING LIPID LEVELS | LIPC, LDLR, PCSK9 | BCHE 653/4885ACHE 2140/4885ALDH1A1 2335/4885 |
| US-20110269754-A1 | COMPOUNDS AND COMPOSITIONS FOR REDUCING LIPID LEVELS | LIPC, LIPE, BCHE | BCHE 3/4885ACHE 302/4885ALDH1A1 4477/4885 |
| US-20070098649-A1 | Method and composition for controlling oral pathogens | BROX, NOP2, FBL | BCHE 85/4885ACHE 1348/4885ALDH1A1 4776/4885 |
| US-20090048246-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR REDUCING LIPID LEVELS | LIPC, BCHE, LIPE | BCHE 2/4885ACHE 276/4885ALDH1A1 4483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.