Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17552003 | 1.00 | ADRA2A (0.42) | ADRA2AADRA2BMAPTNPC1GAA | |
| SCHEMBL17551978 | 1.00 | ADRA2A (0.42) | ADRA2AADRA2BMAPTNPC1GAA | |
| SCHEMBL381475 | 0.83 | MEN1 (0.46) | MAPTNPC1 | |
| SCHEMBL11254435 | 0.82 | MAPT (0.34) | ADRA2AADRA2BMAPT | |
| SCHEMBL2119357 | 0.79 | MAPT (0.55) | ADRA2AADRA2BMAPTNPC1GAA | |
| SCHEMBL2044082 | 0.78 | MAPT (0.54) | ADRA2AADRA2BMAPTNPC1GAA | |
| SCHEMBL7386839 | 0.78 | MAPT (0.47) | MAPTNPC1 | |
| SCHEMBL5176371 | 0.76 | KDM4E (0.44) | ADRA2AADRA2BMAPTNPC1GAA | |
| SCHEMBL14154741 | 0.76 | KDM4E (0.44) | ADRA2AADRA2BMAPTNPC1GAA | |
| SCHEMBL12731994 | 0.76 | MAPT (0.51) | MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-11225655-B2 | Bi-functional complexes and methods for making and using such complexes | NUEVOLUTION A/S (DK) | 2022-01-18 | — | — | US | disclosed |
| EP-3540059-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | Nuevolution A/S (DK) | 2019-09-18 | — | — | EP | disclosed |
| US-20190031695-A1 | Methods and Compositions for Substituted Alpha-Aminophosphonate Analogues | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF (US) | 2019-01-31 | — | — | US | disclosed |
| EP-2558577-B1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION AS (DK) | 2018-12-12 | — | — | EP | disclosed |
| US-20170267707-A1 | Methods and Compositions for Substituted Alpha-Aminophosphonate Analogues | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS | 2017-09-21 | — | — | US | disclosed |
| US-20170267707-A1 | Methods and Compositions for Substituted Alpha-Aminophosphonate Analogues | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS | 2017-09-21 | — | — | US | disclosed |
| US-20130281747-A1 | COBALT PHOSPHINE ALKYL COMPLEXES FOR THE ASYMMETRIC HYDROGENATION OF ALKENES | NATIONAL SCIENCE FOUNDATION | 2013-10-24 | — | — | US | disclosed |
| US-20130281747-A1 | COBALT PHOSPHINE ALKYL COMPLEXES FOR THE ASYMMETRIC HYDROGENATION OF ALKENES | NATIONAL SCIENCE FOUNDATION | 2013-10-24 | — | — | US | disclosed |
| US-20130281324-A1 | BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2013-10-24 | — | — | US | disclosed |
| US-20130281747-A1 | COBALT PHOSPHINE ALKYL COMPLEXES FOR THE ASYMMETRIC HYDROGENATION OF ALKENES | NATIONAL SCIENCE FOUNDATION | 2013-10-24 | — | — | US | disclosed |
| US-8088346-B2 | Alkene hydrofunctionalization reactions | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2012-01-03 | — | — | US | disclosed |
| US-20090069580-A1 | Alkene Hydrofunctionalization Reactions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281747-A1 | COBALT PHOSPHINE ALKYL COMPLEXES FOR THE ASYMMETRIC HYDROGENATION OF ALKENES | CPNE4, FTH1, HRH3 | ADRA2A 3394/4885ADRA2B 4234/4885MAPT 4711/4885 |
| US-20090069580-A1 | Alkene Hydrofunctionalization Reactions | ADH1A, ADH1C, ADH5 | ADRA2A 805/4885ADRA2B 951/4885MAPT 4649/4885 |
| US-20170267707-A1 | Methods and Compositions for Substituted Alpha-Aminophosphonate Analogues | NPEPPS, AGPS, PHOSPHO1 | ADRA2A 2692/4885ADRA2B 3327/4885MAPT 3670/4885 |
| US-20190031695-A1 | Methods and Compositions for Substituted Alpha-Aminophosphonate Analogues | NPEPPS, AGPS, PHOSPHO1 | ADRA2A 2692/4885ADRA2B 3327/4885MAPT 3670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.