SCHEMBL2743975

SCHEMBL2743975

ClC(Cl)(Oc1ccccc1)Oc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.45
LTA4H P09960 3/20 0.45
CA4 P22748 1/20 0.41
KCNA3 P22001 1/20 0.38
CA5A P35218 1/20 0.36
CA5B Q9Y2D0 1/20 0.36
NR1H2 P55055 1/20 0.35
BAX Q07812 1/20 0.35
MAOA P21397 1/20 0.35
ALDH1A1 P00352 2/20 0.33
TAAR1 Q96RJ0 1/20 0.33
RECQL P46063 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
SRC P12931 1/20 0.33
CYP1A2 P05177 1/20 0.33
ORAI1 Q96D31 1/20 0.33
ORAI2 Q96SN7 1/20 0.33
ORAI3 Q9BRQ5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethylamine SCHEMBL9287277 0.90 CA4 (0.40) TSHRLTA4HCA4KCNA3ALDH1A1
SCHEMBL53548 0.82 TSHR (0.45) TSHRLTA4HCA4KCNA3CA5A
SCHEMBL10503197 0.80 TSHR (0.43) TSHRLTA4HCA4KCNA3CA5A
SCHEMBL7032868 0.78 CA4 (0.43) TSHRLTA4HCA4KCNA3CA5A
SCHEMBL8993692 0.78 TSHR (0.41) TSHRLTA4HCA4KCNA3CA5A
SCHEMBL4532633 0.78 ALDH1A1 (0.43) TSHRLTA4HCA4KCNA3CA5A
SCHEMBL11081791 0.78 MAOA (0.42) TSHRLTA4HCA4KCNA3MAOA
SCHEMBL6003069 0.78 LTA4H (0.41) TSHRLTA4HCA4KCNA3CA5A
SCHEMBL10489117 0.78 LTA4H (0.41) TSHRLTA4HCA4KCNA3CA5A
SCHEMBL29071119 0.76 TSHR (0.48) TSHRLTA4HCA4KCNA3CA5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0294686-B1 PROCESS FOR THE PREPARATION OF DIARYLIMINOCARBONATES BASF Aktiengesellschaft (DE) 1992-12-09 EP claimed
US-20260069549-A1 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS MODERNATX INC (US) 2026-03-12 US disclosed
EP-4186888-B1 COMPOUND AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS MODERNATX INC (US) 2025-11-26 EP disclosed
US-20250228777-A1 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS ARES CAPITAL CORPORATION, AS AGENT 2025-07-17 US disclosed
US-12324859-B2 Compounds and compositions for intracellular delivery of therapeutic agents MODERNATX, INC. (US) 2025-06-10 US disclosed
US-12263248-B2 Compounds and compositions for intracellular delivery of therapeutic agents MODERNATX, INC. (US) 2025-04-01 US disclosed
CN-113382767-B Urea compounds having substituents 第一三共株式会社 2024-12-24 CN disclosed
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof CHDI FOUNDATION, INC. (US) 2024-09-10 US disclosed
US-11981686-B2 Urea compound having substituent DAIICHI SANKYO COMPANY, LIMITED (JP) 2024-05-14 US disclosed
EP-4186888-A1 COMPOUND AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS ModernaTX, Inc. (US) 2023-05-31 EP disclosed
US-4851550-A Process for the preparation of cyclic aliphatic orthocarbonic esters new cyclic orthocarbonic esters BAYER AKTIENGESELLSCHAFT (DE) 1989-07-25 US disclosed
EP-0294686-A2 Process for the preparation of diaryliminocarbonates BASF Aktiengesellschaft (DE) 1988-12-14 EP disclosed
EP-0294686-A2 Process for the preparation of diaryliminocarbonates BASF Aktiengesellschaft (DE) 1988-12-14 EP disclosed
EP-0275888-A2 Tricyclic benzimidazoles, process for their preparation and use as medicaments Roche Diagnostics GmbH (DE) 1988-07-27 EP disclosed
EP-0190568-A1 Process for the preparation of spiroorthocarbonates BAYER AG (DE) 1986-08-13 EP disclosed
EP-0034421-B1 N-PHENYL-N'-CYANO-0-PHENYLISOUREAS AND PROCESS FOR THEIR PREPARATION SMITHKLINE BECKMAN CORPORATION (US) 1983-04-27 EP disclosed
EP-0057564-A1 Process for preparing 3,5-diamino-1,2,4-triazoles SMITHKLINE BECKMAN CORPORATION (US) 1982-08-11 EP disclosed
US-4321393-A Method for preparing 2-cyanamidobenzimidazoles or 2-cyanamidobenzoxazoles SMITHKLINE CORPORATION (US) 1982-03-23 US disclosed
EP-0034421-A2 N-phenyl-N'-cyano-0-phenylisoureas and process for their preparation SMITHKLINE BECKMAN CORPORATION (US) 1981-08-26 EP disclosed
US-4285878-A N-Phenyl-N'-cyano-O-phenylisoureas SMITHKLINE CORPORATION (US) 1981-08-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12324859-B2 Compounds and compositions for intracellular delivery of therapeutic agents LNPK, PLTP, PLIN3 TSHR 3089/4885LTA4H 2990/4885CA4 4516/4885
US-11981686-B2 Urea compound having substituent SIRT6, SIRT1, SIRT2 TSHR 3651/4885LTA4H 2686/4885CA4 4459/4885
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof HTT, HYPK, UBQLN2 TSHR 3537/4885LTA4H 4514/4885CA4 4826/4885
US-12263248-B2 Compounds and compositions for intracellular delivery of therapeutic agents LNPK, PLTP, PLIN3 TSHR 3089/4885LTA4H 2990/4885CA4 4516/4885
US-20260069549-A1 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS SIN3A, PLIN3, MSR1 TSHR 540/4885LTA4H 3520/4885CA4 3934/4885
US-20250228777-A1 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS LNPK, PLTP, PLIN3 TSHR 3089/4885LTA4H 2990/4885CA4 4516/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.