Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.59 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.59 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.59 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8200423 | 0.89 | L3MBTL1 (0.67) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL14849461 | 0.83 | PDK1 (0.63) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL83110 | 0.83 | L3MBTL1 (0.78) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL15962158 | 0.82 | EPHX2 (0.57) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL17368411 | 0.82 | KIF11 (0.58) | L3MBTL1TP53MAPTHDAC1HDAC7 | |
| SCHEMBL4281969 | 0.82 | MAPT (0.57) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL4573229 | 0.82 | L3MBTL1 (0.52) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL14263204 | 0.81 | PDK1 (0.57) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL3129785 | 0.81 | PDK1 (0.67) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL436619 | 0.81 | PDK1 (0.61) | PDK1PDK2PDK3PDK4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4443548-A | CULTURES, HYDROLASES, DL-ALPHA-METHYLPHENYLALANINE AMIDE | UBE INDUSTRIES, LTD. (JP) | 1984-04-17 | — | — | US | claimed |
| US-8367666-B2 | 3-carbamoyl-2-pyridone derivatives | SHIONOGI & CO., LTD. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-20120208813-A1 | 3-CARBAMOYL-2-PYRIDONE DERIVATIVES | SHIONOGI & CO., LTD. | 2012-08-16 | — | — | US | disclosed |
| US-8178681-B2 | methyl 3-methyl-2-{[2-oxo-1-(2-oxo-ethyl)-1,2,5,6,7,8,9,10-octahydro-cycloocta[b]pyridine-3-carbonyl]-amino}-butyrate; cannabinoid receptor agonist; antiinflammatory agent, immunostimulant, analgesic; atopic dermatitis; excellent in photostability, and have excellent transdermal and oral absorbency | SHIONOGI & CO., LTD. (JP) | 2012-05-15 | — | — | US | disclosed |
| US-20080103139-A1 | 3-Carbamoyl-2-Pyridone Derivative | SHIONOGI & CO. LTD. (JP) | 2008-05-01 | — | — | US | disclosed |
| EP-1806342-A1 | 3-CARBAMOYL-2-PYRIDONE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2007-07-11 | — | — | EP | disclosed |
| US-4443548-A | CULTURES, HYDROLASES, DL-ALPHA-METHYLPHENYLALANINE AMIDE | UBE INDUSTRIES, LTD. (JP) | 1984-04-17 | — | — | US | disclosed |
| US-4443548-A | CULTURES, HYDROLASES, DL-ALPHA-METHYLPHENYLALANINE AMIDE | UBE INDUSTRIES, LTD. (JP) | 1984-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208813-A1 | 3-CARBAMOYL-2-PYRIDONE DERIVATIVES | CNR2, CNR1, HRH4 | PDK1 3219/4885PDK2 3523/4885PDK3 3413/4885 |
| US-20080103139-A1 | 3-Carbamoyl-2-Pyridone Derivative | CNR1, CNR2, HRH4 | PDK1 3192/4885PDK2 3865/4885PDK3 3286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.