Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56590 | 0.81 | MAOB (0.48) | SLC6A3MAOAMAOB | |
| SCHEMBL6888881 | 0.80 | HSD11B1 (0.50) | OPRM1SLC6A3DRD2LMNAALDH1A1 | |
| SCHEMBL56772 | 0.80 | OPRM1 (0.60) | OPRM1SLC6A4KCNH2DRD4 | |
| SCHEMBL23112661 | 0.80 | MAOB (0.41) | OPRM1SLC6A3KMT2AMAOAMAOB | |
| Hydrochloric Acid SCHEMBL1918396 | 0.79 | MAOB (0.46) | SLC6A3MAOAMAOB | |
| SCHEMBL3030734 | 0.79 | OPRM1 (0.39) | OPRM1SLC6A3KMT2ADRD4 | |
| SCHEMBL15715779 | 0.78 | OPRM1 (0.48) | OPRM1SMN1; SMN2DUSP3PTPN5PTPN11 | |
| SCHEMBL6926354 | 0.78 | OPRM1 (0.51) | OPRM1SMN1; SMN2DUSP3PTPN5PTPN11 | |
| SCHEMBL20491450 | 0.78 | RORC (0.44) | ALDH1A1 | |
| SCHEMBL8254657 | 0.77 | SLC6A3 (0.48) | SLC6A3MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324865-A1 | SUBSTITUTED DIHYDROPYRAZOLO PYRAZINE CARBOXAMIDE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2022-10-13 | — | — | US | disclosed |
| EP-3793559-A1 | SUBSTITUTED DIHYDROPYRAZOLO PYRAZINE CARBOXAMIDE DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2021-03-24 | — | — | EP | disclosed |
| CN-112469412-A | Substituted dihydropyrazolopyrazine carboxamide derivatives | 拜耳公司 | 2021-03-09 | — | — | CN | disclosed |
| EP-1753739-B1 | IMIDAZOL-2-ONE COMPOUNDS USEFUL IN THE TREATMENT OF VARIOUS DISORDERS | GLAXO GROUP LTD (GB) | 2010-04-28 | — | — | EP | disclosed |
| US-7534893-B2 | Imidazol-2-one compounds useful in the treatment of various disorders | GLAXO GROUP LIMITED (GB) | 2009-05-19 | — | — | US | disclosed |
| US-20070249679-A1 | Imidazol-2-One Compounds Useful in the Treatment of Various Disorders | GLAXO GROUP LIMITED (GB) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324865-A1 | SUBSTITUTED DIHYDROPYRAZOLO PYRAZINE CARBOXAMIDE DERIVATIVES | QDPR, SIRT5, PDXK | OPRM1 3834/4885SMN1; SMN2 3131/4885DUSP3 816/4885 |
| US-20070249679-A1 | Imidazol-2-One Compounds Useful in the Treatment of Various Disorders | SLC6A4, SLC18A2, SLC18A1 | OPRM1 167/4885SMN1; SMN2 1787/4885DUSP3 3519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.