Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | CES2 | O00748 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL139043 | 0.98 | LMNA (0.59) | LMNACES2CES1MEN1KMT2A | |
| Carbamic Acid SCHEMBL1695355 | 0.94 | LMNA (0.54) | LMNACES2CES1MEN1KMT2A | |
| Bicarbonate SCHEMBL291493 | 0.87 | CES2 (0.58) | LMNACES2CES1MEN1KMT2A | |
| SCHEMBL6203480 | 0.86 | CES2 (0.61) | LMNACES2CES1MEN1KMT2A | |
| SCHEMBL139044 | 0.85 | CES2 (0.59) | LMNACES2CES1MEN1KMT2A | |
| SCHEMBL14181968 | 0.84 | CES2 (0.48) | CES2CES1MEN1KMT2AKDM4E | |
| SCHEMBL29262742 | 0.83 | LMNA (0.67) | LMNACES2CES1MEN1KMT2A | |
| Benzoin SCHEMBL15326953 | 0.83 | LMNA (0.72) | LMNACES2CES1MEN1KMT2A | |
| SCHEMBL812736 | 0.83 | LMNA (0.67) | LMNACES2CES1MEN1KMT2A | |
| Acetic Acid SCHEMBL3368380 | 0.83 | CES2 (0.56) | LMNACES2CES1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401851-B1 | TWO-STAGE PROTECTIVE GROUPS FOR THE SYNTHESIS OF BIOPOLYMERS | FEBIT BIOTECH GMBH (DE) | 2008-07-02 | — | — | EP | claimed |
| US-7355036-B2 | Two-stage protective groups for the synthesis of biopolymers | FEBIT AG (DE) | 2008-04-08 | — | — | US | claimed |
| US-20040197851-A1 | Two-stage protective groups for the synthesis of biopolymers | MR. CHRISTOPHER SEAGON, ESQ. (DE) | 2004-10-07 | — | — | US | claimed |
| EP-1981544-B1 | BIODEGRADABLE AND THERMOSENSITIVE POLY(ORGANOPHOSPHAZENE) HYDROGEL, PREPARATION METHOD THEREOF AND USE THEREOF | KIST KOREA INSTITUTE OF SCIENCE AND TECH (KR) | 2019-06-19 | — | — | EP | disclosed |
| US-9526699-B2 | Biodegradable and thermosensitive poly(organophosphazene) hydrogel, preparation method thereof and use thereof | KIST (KR) | 2016-12-27 | — | — | US | disclosed |
| EP-2001513-B1 | THERMOSENSITIVE POLYPHOSPHAZENE-BIOACTIVE MOLECULE CONJUGATES, PREPARATION METHOD THEROF AND USE THEREOF | KOREA INST SCI & TECH (KR) | 2016-06-01 | — | — | EP | disclosed |
| US-9017726-B2 | Biodegradable and thermosensitive poly(organophosphazene)-superparamagnetic nanoparticle complex, preparation method and use thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2015-04-28 | — | — | US | disclosed |
| US-20140031289-A1 | POLY(ORGANOPHOSPHAZENE) CONTAINING DEGRADATION CONTROLLABLE IONIC GROUP, PREPARATION METHOD THEREOF AND USE THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-01-30 | — | — | US | disclosed |
| US-20130004455-A1 | POLY(ORGANOPHOSPHAZENE) COMPOSITION FOR BIOMATERIALS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2013-01-03 | — | — | US | disclosed |
| EP-2540764-A2 | Poly(organophosphazene) composition for biomaterials | Korea Institute of Science and Technology (KR) | 2013-01-02 | — | — | EP | disclosed |
| US-8313771-B2 | Phosphazene hydrogels with chemical corss-link, preparation method thereof and use thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-11-20 | — | — | US | disclosed |
| US-20090022683-A1 | Biodegradable and Thermosensitive Poly(Organophosphazene) Hydrogel, Preparation Method Thereof and Use Thereof | KIST (KR) | 2009-01-22 | — | — | US | disclosed |
| WO-2008153278-A1 | PHOSPHAZENE HYDROGELS WITH CHEMICAL CORSS -LINK, PREPARATION METHOD THEREOF AND USE THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008153277-A1 | POLY(ORGANOPHOSPHAZENE) HYDROGELS FOR DRUG DELIVERY, PREPARATION METHOD THEREOF AND USE THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-12-18 | — | — | WO | disclosed |
| EP-2001513-A1 | THERMOSENSITIVE POLYPHOSPHAZENE-BIOACTIVE MOLECULE CONJUGATES, PREPARATION METHOD THEROF AND USE THEREOF | Korea Institute of Science and Technology (KR) | 2008-12-17 | — | — | EP | disclosed |
| EP-1981544-A2 | BIODEGRADABLE AND THERMOSENSITIVE POLY(ORGANOPHOSPHAZENE) HYDROGEL, PREPARATION METHOD THEREOF AND USE THEREOF | KIST Korea Institute of Science and Technology (KR) | 2008-10-22 | — | — | EP | disclosed |
| US-7355036-B2 | Two-stage protective groups for the synthesis of biopolymers | FEBIT AG (DE) | 2008-04-08 | — | — | US | disclosed |
| WO-2007114549-A1 | THERMOSENSITIVE POLYPHOSPHAZENE-BIOACTIVE MOLECULE CONJUGATES, PREPARATION METHOD THEROF AND USE THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2007-10-11 | — | — | WO | disclosed |
| WO-2007083875-A2 | BIODEGRADABLE AND THERMOSENSITIVE POLY(ORGANOPHOSPHAZENE) HYDROGEL, PREPARATION METHOD THEREOF AND USE THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2007-07-26 | — | — | WO | disclosed |
| US-20040197851-A1 | Two-stage protective groups for the synthesis of biopolymers | MR. CHRISTOPHER SEAGON, ESQ. (DE) | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130004455-A1 | POLY(ORGANOPHOSPHAZENE) COMPOSITION FOR BIOMATERIALS | PHOSPHO1, PGLS, PHYKPL | LMNA 2870/4885CES2 583/4885CES1 590/4885 |
| US-20040197851-A1 | Two-stage protective groups for the synthesis of biopolymers | CTRB2, OGG1, CPB2 | LMNA 514/4885CES2 205/4885CES1 2432/4885 |
| US-20090022683-A1 | Biodegradable and Thermosensitive Poly(Organophosphazene) Hydrogel, Preparation Method Thereof and Use Thereof | PHOSPHO1, PGLS, LIPE | LMNA 3756/4885CES2 1964/4885CES1 1155/4885 |
| US-20140031289-A1 | POLY(ORGANOPHOSPHAZENE) CONTAINING DEGRADATION CONTROLLABLE IONIC GROUP, PREPARATION METHOD THEREOF AND USE THEREOF | PHOSPHO1, PLCB3, INPP5D | LMNA 3315/4885CES2 644/4885CES1 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.